STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
thyAThymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (269 aa)    
Predicted Functional Partners:
APH03134.1
Diacylglycerol kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the dihydrofolate reductase family.
 
 
 0.998
APH01291.1
Thymidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.983
dut
Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family.
  
 0.980
APH00834.1
Serine hydroxymethyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.959
APH01035.1
Dihydrofolate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.958
APH02318.1
Thymidylate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.957
APH01863.1
Dihydrofolate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
 0.946
APH02108.1
Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.925
APH02494.1
Deoxycytidine triphosphate deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 0.921
APH01226.1
Glycine cleavage system protein T; Derived by automated computational analysis using gene prediction method: Protein Homology.
    
 0.911
Your Current Organism:
Janibacter terrae
NCBI taxonomy Id: 103817
Other names: ATCC BAA-130, CCUG 45369, CIP 107018, DSM 13876, DSM 13953 [[Janibacter brevis Imamura et al. 2000]], J. terrae, JCM 10705, JCM 12887 [[Janibacter brevis Imamura et al. 2000]], Janibacter brevis, Janibacter brevis Imamura et al. 2000, Janibacter terrae Yoon et al. 2000 emend. Lang et al. 2003, KCCM 80001, KCTC 19953, NBRC 107853, strain 10N [[Janibacter brevis Imamura et al. 2000]], strain CS12
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