node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
APV40083.1 | APV40084.1 | PFAS1_12255 | PFAS1_12260 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Heme biosynthesis operon protein HemX; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.993 |
APV40083.1 | APV40085.1 | PFAS1_12255 | PFAS1_12265 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Heme biosynthesis protein HemY; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.893 |
APV40083.1 | APV40086.1 | PFAS1_12255 | PFAS1_12270 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Disulfide bond formation protein B; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.592 |
APV40083.1 | APV41637.1 | PFAS1_12255 | PFAS1_20605 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | uroporphyrinogen-III C-methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.924 |
APV40083.1 | APV42917.1 | PFAS1_12255 | PFAS1_27760 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | uroporphyrinogen-III C-methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.924 |
APV40083.1 | cysG | PFAS1_12255 | PFAS1_01095 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | 0.963 |
APV40083.1 | hemC | PFAS1_12255 | PFAS1_12250 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.997 |
APV40083.1 | hemE | PFAS1_12255 | PFAS1_09080 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.948 |
APV40084.1 | APV40083.1 | PFAS1_12260 | PFAS1_12255 | Heme biosynthesis operon protein HemX; Derived by automated computational analysis using gene prediction method: Protein Homology. | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.993 |
APV40084.1 | APV40085.1 | PFAS1_12260 | PFAS1_12265 | Heme biosynthesis operon protein HemX; Derived by automated computational analysis using gene prediction method: Protein Homology. | Heme biosynthesis protein HemY; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.979 |
APV40084.1 | APV40086.1 | PFAS1_12260 | PFAS1_12270 | Heme biosynthesis operon protein HemX; Derived by automated computational analysis using gene prediction method: Protein Homology. | Disulfide bond formation protein B; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.696 |
APV40084.1 | APV41637.1 | PFAS1_12260 | PFAS1_20605 | Heme biosynthesis operon protein HemX; Derived by automated computational analysis using gene prediction method: Protein Homology. | uroporphyrinogen-III C-methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.905 |
APV40084.1 | APV42917.1 | PFAS1_12260 | PFAS1_27760 | Heme biosynthesis operon protein HemX; Derived by automated computational analysis using gene prediction method: Protein Homology. | uroporphyrinogen-III C-methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.905 |
APV40084.1 | APV43127.1 | PFAS1_12260 | PFAS1_08095 | Heme biosynthesis operon protein HemX; Derived by automated computational analysis using gene prediction method: Protein Homology. | Precorrin-2 C(20)-methyltransferase; Methylates precorrin-2 at the C-20 position to produce precorrin-3A. | 0.900 |
APV40084.1 | cysG | PFAS1_12260 | PFAS1_01095 | Heme biosynthesis operon protein HemX; Derived by automated computational analysis using gene prediction method: Protein Homology. | uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | 0.912 |
APV40084.1 | hemC | PFAS1_12260 | PFAS1_12250 | Heme biosynthesis operon protein HemX; Derived by automated computational analysis using gene prediction method: Protein Homology. | Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.858 |
APV40084.1 | hemE | PFAS1_12260 | PFAS1_09080 | Heme biosynthesis operon protein HemX; Derived by automated computational analysis using gene prediction method: Protein Homology. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.912 |
APV40084.1 | lptE | PFAS1_12260 | PFAS1_14960 | Heme biosynthesis operon protein HemX; Derived by automated computational analysis using gene prediction method: Protein Homology. | Hypothetical protein; Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane. | 0.696 |
APV40085.1 | APV40083.1 | PFAS1_12265 | PFAS1_12255 | Heme biosynthesis protein HemY; Derived by automated computational analysis using gene prediction method: Protein Homology. | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.893 |
APV40085.1 | APV40084.1 | PFAS1_12265 | PFAS1_12260 | Heme biosynthesis protein HemY; Derived by automated computational analysis using gene prediction method: Protein Homology. | Heme biosynthesis operon protein HemX; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.979 |