node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
KXV62527.1 | KXV62740.1 | AD949_10415 | AD949_09810 | Homoserine dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.951 |
KXV62527.1 | KXV63092.1 | AD949_10415 | AD949_07395 | Homoserine dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Cystathionine beta-lyase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.898 |
KXV62527.1 | KXV65003.1 | AD949_10415 | AD949_05370 | Homoserine dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Methylenetetrahydrofolate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the methylenetetrahydrofolate reductase family. | 0.680 |
KXV62527.1 | ahcY | AD949_10415 | AD949_08795 | Homoserine dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | 0.867 |
KXV62527.1 | cysK | AD949_10415 | AD949_04650 | Homoserine dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Cysteine synthase; CysK; forms a complex with serine acetyltransferase CysE; functions in cysteine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.438 |
KXV62527.1 | metE | AD949_10415 | AD949_01875 | Homoserine dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Catalyzes the formation of tetrahydropteroyl-L-glutamate and methionine from L-homocysteine and 5-methyltetrahydropteroyltri-L-glutamate; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.909 |
KXV62527.1 | metZ | AD949_10415 | AD949_02600 | Homoserine dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. | O-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. | 0.911 |
KXV62740.1 | KXV62527.1 | AD949_09810 | AD949_10415 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Homoserine dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.951 |
KXV62740.1 | KXV63092.1 | AD949_09810 | AD949_07395 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Cystathionine beta-lyase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.962 |
KXV62740.1 | KXV65003.1 | AD949_09810 | AD949_05370 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Methylenetetrahydrofolate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the methylenetetrahydrofolate reductase family. | 0.997 |
KXV62740.1 | ahcY | AD949_09810 | AD949_08795 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | 0.954 |
KXV62740.1 | cysK | AD949_09810 | AD949_04650 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Cysteine synthase; CysK; forms a complex with serine acetyltransferase CysE; functions in cysteine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.917 |
KXV62740.1 | gcvP | AD949_09810 | AD949_09945 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.960 |
KXV62740.1 | metE | AD949_09810 | AD949_01875 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Catalyzes the formation of tetrahydropteroyl-L-glutamate and methionine from L-homocysteine and 5-methyltetrahydropteroyltri-L-glutamate; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.963 |
KXV62740.1 | metK2 | AD949_09810 | AD949_05790 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.954 |
KXV62740.1 | metZ | AD949_09810 | AD949_02600 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | O-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. | 0.967 |
KXV63092.1 | KXV62527.1 | AD949_07395 | AD949_10415 | Cystathionine beta-lyase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Homoserine dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.898 |
KXV63092.1 | KXV62740.1 | AD949_07395 | AD949_09810 | Cystathionine beta-lyase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.962 |
KXV63092.1 | KXV65003.1 | AD949_07395 | AD949_05370 | Cystathionine beta-lyase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Methylenetetrahydrofolate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the methylenetetrahydrofolate reductase family. | 0.818 |
KXV63092.1 | ahcY | AD949_07395 | AD949_08795 | Cystathionine beta-lyase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | 0.881 |