STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KXV62482.1Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (484 aa)    
Predicted Functional Partners:
gltA
Type II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the citrate synthase family.
   
  0.892
KXV62406.1
Part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
   
 0.887
fumC
Fumarate hydratase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
    
 0.880
KXV62700.1
Fumarate hydratase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family.
   
 
 0.876
citC
Isocitrate dehydrogenase; Catalyzes the formation of 2-oxoglutarate from isocitrate; Derived by automated computational analysis using gene prediction method: Protein Homology.
    
  0.872
mqo1
Malate:quinone oxidoreductase; Malate dehydrogenase; catalyzes the oxidation of malate to oxaloacetate; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
 
 0.870
sucA
SucA; E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate; SucA catalyzes the reaction of 2-oxoglutarate with dihydrolipoamide succinyltransferase-lipoate to form dihydrolipoamide succinyltransferase-succinyldihydrolipoate and carbon dioxide; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
 
 0.868
sdhB
Succinate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
   
 
 0.868
KXV62404.1
Succinate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
 
  0.863
KXV65233.1
Converts isocitrate to alpha ketoglutarate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the isocitrate and isopropylmalate dehydrogenases family.
   
 
 0.860
Your Current Organism:
Acetobacter orleanensis
NCBI taxonomy Id: 104099
Other names: A. orleanensis, ATCC 12876, Acetobacter aceti subsp. orleanensis, Acetobacter mesoxydans, Acetobacter orleanense, Bacillus orleanensis, Bacterium dihydroxyacetonicum, Bacterium orleanense, CCUG 18126, DSM 4492, IFO 13752, JCM 7639, NBRC 13752, NCCB 31003, NCIMB 8622, Ulvina orleanense
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