A0A074X9X6 protein (Aureobasidium pullulans)

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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co-expression

protein homology

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Score

A0A074X9X6

C2H2-type domain-containing protein. (418 aa)

Predicted Functional Partners:

A0A074X1C8

0.744

A0A074XDY3

0.744

A0A074XE52

0.744

A0A074X9X2

0.718

A0A074X9M7

0.545

A0A074XKI6

0.545

A0A074XNT7

0.545

A0A074XZT6

0.545

A0A074XXM1

0.544

A0A074YE93

0.544

Your Current Organism:

Aureobasidium pullulans

NCBI taxonomy Id: 1043002
Other names: A. pullulans EXF-150, Aureobasidium pullulans EXF-150, Aureobasidium pullulans var. pullulans EXF-150

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A074X1C8	A0A074X9X6	Uncharacterized protein.	C2H2-type domain-containing protein.	0.744
A0A074X1C8	A0A074XDY3	Uncharacterized protein.	Nitrate reductase; Nitrate reductase is a key enzyme involved in the first step of nitrate assimilation in plants, fungi and bacteria.	0.967
A0A074X1C8	A0A074XE52	Uncharacterized protein.	Uncharacterized protein.	0.965
A0A074X9M7	A0A074X9X6	Ribosomal protein S16, mitochondrial.	C2H2-type domain-containing protein.	0.545
A0A074X9M7	A0A074XKI6	Ribosomal protein S16, mitochondrial.	Translational machinery component.	0.999
A0A074X9M7	A0A074XNT7	Ribosomal protein S16, mitochondrial.	Uncharacterized protein.	0.999
A0A074X9M7	A0A074XXM1	Ribosomal protein S16, mitochondrial.	Ribosomal protein S6.	0.999
A0A074X9M7	A0A074XZT6	Ribosomal protein S16, mitochondrial.	Uncharacterized protein.	0.999
A0A074X9M7	A0A074YE93	Ribosomal protein S16, mitochondrial.	Uncharacterized protein; Belongs to the universal ribosomal protein uS9 family.	0.999
A0A074X9X2	A0A074X9X6	Uncharacterized protein.	C2H2-type domain-containing protein.	0.718
A0A074X9X6	A0A074X1C8	C2H2-type domain-containing protein.	Uncharacterized protein.	0.744
A0A074X9X6	A0A074X9M7	C2H2-type domain-containing protein.	Ribosomal protein S16, mitochondrial.	0.545
A0A074X9X6	A0A074X9X2	C2H2-type domain-containing protein.	Uncharacterized protein.	0.718
A0A074X9X6	A0A074XDY3	C2H2-type domain-containing protein.	Nitrate reductase; Nitrate reductase is a key enzyme involved in the first step of nitrate assimilation in plants, fungi and bacteria.	0.744
A0A074X9X6	A0A074XE52	C2H2-type domain-containing protein.	Uncharacterized protein.	0.744
A0A074X9X6	A0A074XKI6	C2H2-type domain-containing protein.	Translational machinery component.	0.545
A0A074X9X6	A0A074XNT7	C2H2-type domain-containing protein.	Uncharacterized protein.	0.545
A0A074X9X6	A0A074XXM1	C2H2-type domain-containing protein.	Ribosomal protein S6.	0.544
A0A074X9X6	A0A074XZT6	C2H2-type domain-containing protein.	Uncharacterized protein.	0.545
A0A074X9X6	A0A074YE93	C2H2-type domain-containing protein.	Uncharacterized protein; Belongs to the universal ribosomal protein uS9 family.	0.544

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

29

average node degree:

5.27

avg. local clustering coefficient:

0.751

expected number of edges:

10

PPI enrichment p-value:

1.85e-06

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030433

Ubiquitin-dependent ERAD pathway

5 of 41

1.99

2.86

6.76e-07

GO:0016567

Protein ubiquitination

7 of 125

1.66

2.55

1.50e-07

GO:0010033

Response to organic substance

7 of 150

1.58

2.37

1.86e-07

GO:0043161

Proteasome-mediated ubiquitin-dependent protein catabolic process

6 of 144

1.53

2.02

2.64e-06

GO:0051603

Proteolysis involved in protein catabolic process

7 of 235

1.38

1.83

1.20e-06

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004842

Ubiquitin-protein transferase activity

6 of 90

1.73

2.46

9.21e-07

GO:0061631

Ubiquitin conjugating enzyme activity

3 of 26

1.97

1.38

0.0020

GO:0043130

Ubiquitin binding

3 of 29

1.92

1.36

0.0020

GO:0097027

Ubiquitin-protein transferase activator activity

2 of 5

2.51

1.23

0.0056

GO:0061630

Ubiquitin protein ligase activity

3 of 52

1.67

1.09

0.0056

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000836

Hrd1p ubiquitin ligase complex

3 of 5

2.69

2.31

5.57e-05

GO:0000151

Ubiquitin ligase complex

4 of 70

1.66

1.61

0.00023

GO:0140535

Intracellular protein-containing complex

7 of 371

1.18

1.24

5.57e-05

GO:1990234

Transferase complex

5 of 340

1.08

0.8

0.0045

GO:0005783

Endoplasmic reticulum

5 of 429

0.97

0.66

0.0101

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:7371

Mixed, incl. Ubiquitin-dependent ERAD pathway, and Hedgehog ligand biogenesis

5 of 40

2.0

2.69

1.91e-06

CL:604

Ubiquitin-conjugating enzyme E2

3 of 7

2.54

2.29

5.41e-05

CL:567

Mixed, incl. Ubiquitin-like protein conjugating enzyme activity, and HECT domain

4 of 45

1.86

1.98

5.99e-05

CL:7375

Ubiquitin-dependent ERAD pathway, and Hedgehog ligand biogenesis

3 of 29

1.92

1.48

0.0011

CL:13337

CCR4-NOT core complex, and Ubiquitin-protein transferase regulator activity

2 of 10

2.21

1.06

0.0105

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04141

Protein processing in endoplasmic reticulum

7 of 168

1.53

2.39

4.77e-08

map04120

Ubiquitin mediated proteolysis

4 of 102

1.5

1.39

0.00045

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0000835

ER ubiquitin ligase complex

4 of 12

2.43

2.96

2.18e-06

GOCC:0000151

Ubiquitin ligase complex

5 of 76

1.73

2.17

7.77e-06

GOCC:1990389

CUE1-UBC7 ubiquitin-conjugating enzyme complex

2 of 2

2.91

1.59

0.0013

GOCC:0005789

Endoplasmic reticulum membrane

5 of 137

1.47

1.55

9.85e-05

GOCC:0000836

Hrd1p ubiquitin ligase complex

2 of 10

2.21

1.13

0.0079

(more ...)

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR000608

Ubiquitin-conjugating enzyme E2

3 of 23

2.02

1.06

0.0098

IPR016135

Ubiquitin-conjugating enzyme/RWD-like

3 of 28

1.94

1.04

0.0098

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00184

Ring finger

3 of 55

1.64

0.92

0.0129

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