A0A074XV86 protein (Aureobasidium pullulans)

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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gene co-occurrence

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Score

A0A074XV86

Kinase-like protein. (560 aa)

Predicted Functional Partners:

A0A074XCZ9

0.856

A0A074XZ45

0.851

A0A074Y2G3

0.793

A0A074XW54

0.722

A0A074WZ78

0.708

A0A074Y0Q8

0.708

A0A074XVF6

0.693

A0A074Y2F4

0.670

A0A074XSP4

0.652

A0A074XK10

0.628

Your Current Organism:

Aureobasidium pullulans

NCBI taxonomy Id: 1043002
Other names: A. pullulans EXF-150, Aureobasidium pullulans EXF-150, Aureobasidium pullulans var. pullulans EXF-150

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A074WZ78	A0A074XV86	Ubiquitin-like protein.	Kinase-like protein.	0.708
A0A074WZ78	A0A074XW54	Ubiquitin-like protein.	Ubiquitin-conjugating enzyme; Belongs to the ubiquitin-conjugating enzyme family.	0.999
A0A074WZ78	A0A074Y0Q8	Ubiquitin-like protein.	Ubiquitin-like domain-containing protein.	0.920
A0A074WZ78	A0A074Y2F4	Ubiquitin-like protein.	Serine/threonine-protein kinase Tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability; Belongs to the PI3/PI4-kinase family. ATM subfamily.	0.655
A0A074XCZ9	A0A074XV86	RhoGAP-domain-containing protein.	Kinase-like protein.	0.856
A0A074XCZ9	A0A074Y2G3	RhoGAP-domain-containing protein.	Small GTPase.	0.981
A0A074XK10	A0A074XV86	YDG domain-containing protein.	Kinase-like protein.	0.628
A0A074XSP4	A0A074XV86	DNA glycosylase.	Kinase-like protein.	0.652
A0A074XV86	A0A074WZ78	Kinase-like protein.	Ubiquitin-like protein.	0.708
A0A074XV86	A0A074XCZ9	Kinase-like protein.	RhoGAP-domain-containing protein.	0.856
A0A074XV86	A0A074XK10	Kinase-like protein.	YDG domain-containing protein.	0.628
A0A074XV86	A0A074XSP4	Kinase-like protein.	DNA glycosylase.	0.652
A0A074XV86	A0A074XVF6	Kinase-like protein.	Peptidyl-prolyl cis-trans isomerase.	0.693
A0A074XV86	A0A074XW54	Kinase-like protein.	Ubiquitin-conjugating enzyme; Belongs to the ubiquitin-conjugating enzyme family.	0.722
A0A074XV86	A0A074XZ45	Kinase-like protein.	WD40 repeat-like protein.	0.851
A0A074XV86	A0A074Y0Q8	Kinase-like protein.	Ubiquitin-like domain-containing protein.	0.708
A0A074XV86	A0A074Y2F4	Kinase-like protein.	Serine/threonine-protein kinase Tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability; Belongs to the PI3/PI4-kinase family. ATM subfamily.	0.670
A0A074XV86	A0A074Y2G3	Kinase-like protein.	Small GTPase.	0.793
A0A074XVF6	A0A074XV86	Peptidyl-prolyl cis-trans isomerase.	Kinase-like protein.	0.693
A0A074XW54	A0A074WZ78	Ubiquitin-conjugating enzyme; Belongs to the ubiquitin-conjugating enzyme family.	Ubiquitin-like protein.	0.999

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

27

average node degree:

4.91

avg. local clustering coefficient:

0.868

expected number of edges:

12

PPI enrichment p-value:

0.000125

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008299

Isoprenoid biosynthetic process

7 of 22

2.47

5.95

7.82e-13

GO:0018343

Protein farnesylation

2 of 2

2.96

1.5

0.0019

GO:0019408

Dolichol biosynthetic process

2 of 4

2.66

1.31

0.0041

GO:1901615

Organic hydroxy compound metabolic process

4 of 105

1.54

1.27

0.0013

GO:0016114

Terpenoid biosynthetic process

2 of 11

2.22

1.02

0.0130

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016765

Transferase activity, transferring alkyl or aryl (other than methyl) groups

8 of 41

2.25

6.02

3.64e-14

GO:0004659

Prenyltransferase activity

6 of 12

2.66

5.89

3.86e-12

GO:0004660

Protein farnesyltransferase activity

2 of 2

2.96

1.47

0.0022

GO:0004337

Geranyltranstransferase activity

2 of 2

2.96

1.47

0.0022

GO:0004161

Dimethylallyltranstransferase activity

2 of 2

2.96

1.47

0.0022

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005965

Protein farnesyltransferase complex

2 of 2

2.96

1.27

0.0051

GO:1990234

Transferase complex

5 of 345

1.12

0.78

0.0074

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:9992

Isoprenoid biosynthetic process, and Protein farnesylation

9 of 18

2.66

9.3

1.21e-19

CL:9995

Prenyltransferase activity

6 of 6

2.96

6.98

8.26e-14

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00900

Terpenoid backbone biosynthesis

8 of 30

2.39

7.12

4.13e-16

map01110

Biosynthesis of secondary metabolites

8 of 447

1.22

1.61

1.61e-07

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-446199

Synthesis of Dolichyl-phosphate

3 of 7

2.6

2.14

0.00011

MAP-446219

Synthesis of substrates in N-glycan biosythesis

3 of 22

2.1

1.55

0.0010

MAP-191273

Cholesterol biosynthesis

3 of 24

2.06

1.54

0.0010

MAP-446193

Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein

3 of 39

1.85

1.3

0.0025

MAP-2142789

Ubiquinol biosynthesis

2 of 8

2.36

1.15

0.0074

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:1904423

Dehydrodolichyl diphosphate synthase complex

2 of 2

2.96

1.21

0.0064

GOCC:0005965

Protein farnesyltransferase complex

2 of 2

2.96

1.21

0.0064

GOCC:1990234

Transferase complex

5 of 374

1.09

0.74

0.0091

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0808

Transferase

5 of 336

1.14

0.86

0.0037

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00348

Polyprenyl synthetase

3 of 3

2.96

2.61

1.78e-05

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR033749

Polyprenyl synthetase, conserved site

3 of 3

2.96

2.36

5.09e-05

IPR000092

Polyprenyl synthetase

3 of 3

2.96

2.36

5.09e-05

IPR008949

Isoprenoid synthase domain superfamily

3 of 5

2.74

2.34

5.09e-05

IPR036424

Decaprenyl diphosphate synthase-like superfamily

2 of 2

2.96

1.31

0.0043

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