A0A074Y4S0 protein (Aureobasidium pullulans)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

A0A074Y4S0

Ammonium transporter. (522 aa)

Predicted Functional Partners:

A0A074XEE8

0.506

A0A074X1C8

0.472

A0A074XDY3

0.472

A0A074XE52

0.472

A0A074XW86

0.471

A0A074X877

0.417

A0A074YG28

0.410

A0A074XIF8

0.403

A0A074Y7D7

0.403

Your Current Organism:

Aureobasidium pullulans

NCBI taxonomy Id: 1043002
Other names: A. pullulans EXF-150, Aureobasidium pullulans EXF-150, Aureobasidium pullulans var. pullulans EXF-150

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A074X1C8	A0A074XDY3	Uncharacterized protein.	Nitrate reductase; Nitrate reductase is a key enzyme involved in the first step of nitrate assimilation in plants, fungi and bacteria.	0.967
A0A074X1C8	A0A074XE52	Uncharacterized protein.	Uncharacterized protein.	0.965
A0A074X1C8	A0A074XIF8	Uncharacterized protein.	Glutamine synthetase/guanido kinase; Belongs to the glutamine synthetase family.	0.681
A0A074X1C8	A0A074XW86	Uncharacterized protein.	Glutamine synthetase.	0.681
A0A074X1C8	A0A074Y4S0	Uncharacterized protein.	Ammonium transporter.	0.472
A0A074X1C8	A0A074Y7D7	Uncharacterized protein.	Glutamine synthetase/guanido kinase; Belongs to the glutamine synthetase family.	0.681
A0A074X1C8	A0A074YG28	Uncharacterized protein.	Uncharacterized protein.	0.404
A0A074X877	A0A074Y4S0	Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family.	Ammonium transporter.	0.417
A0A074X877	A0A074YG28	Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family.	Uncharacterized protein.	0.415
A0A074XDY3	A0A074X1C8	Nitrate reductase; Nitrate reductase is a key enzyme involved in the first step of nitrate assimilation in plants, fungi and bacteria.	Uncharacterized protein.	0.967
A0A074XDY3	A0A074XE52	Nitrate reductase; Nitrate reductase is a key enzyme involved in the first step of nitrate assimilation in plants, fungi and bacteria.	Uncharacterized protein.	0.965
A0A074XDY3	A0A074XIF8	Nitrate reductase; Nitrate reductase is a key enzyme involved in the first step of nitrate assimilation in plants, fungi and bacteria.	Glutamine synthetase/guanido kinase; Belongs to the glutamine synthetase family.	0.681
A0A074XDY3	A0A074XW86	Nitrate reductase; Nitrate reductase is a key enzyme involved in the first step of nitrate assimilation in plants, fungi and bacteria.	Glutamine synthetase.	0.681
A0A074XDY3	A0A074Y4S0	Nitrate reductase; Nitrate reductase is a key enzyme involved in the first step of nitrate assimilation in plants, fungi and bacteria.	Ammonium transporter.	0.472
A0A074XDY3	A0A074Y7D7	Nitrate reductase; Nitrate reductase is a key enzyme involved in the first step of nitrate assimilation in plants, fungi and bacteria.	Glutamine synthetase/guanido kinase; Belongs to the glutamine synthetase family.	0.681
A0A074XDY3	A0A074YG28	Nitrate reductase; Nitrate reductase is a key enzyme involved in the first step of nitrate assimilation in plants, fungi and bacteria.	Uncharacterized protein.	0.404
A0A074XE52	A0A074X1C8	Uncharacterized protein.	Uncharacterized protein.	0.965
A0A074XE52	A0A074XDY3	Uncharacterized protein.	Nitrate reductase; Nitrate reductase is a key enzyme involved in the first step of nitrate assimilation in plants, fungi and bacteria.	0.965
A0A074XE52	A0A074XIF8	Uncharacterized protein.	Glutamine synthetase/guanido kinase; Belongs to the glutamine synthetase family.	0.681
A0A074XE52	A0A074XW86	Uncharacterized protein.	Glutamine synthetase.	0.681

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

50

average node degree:

9.09

avg. local clustering coefficient:

0.949

expected number of edges:

18

PPI enrichment p-value:

6.48e-10

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0007165

Signal transduction

8 of 71

1.56

2.62

7.29e-09

GO:0018106

Peptidyl-histidine phosphorylation

6 of 43

1.65

2.46

3.08e-07

GO:0009889

Regulation of biosynthetic process

8 of 212

1.08

1.25

2.00e-06

GO:0080090

Regulation of primary metabolic process

8 of 220

1.07

1.22

2.49e-06

GO:0050789

Regulation of biological process

10 of 329

0.99

1.16

1.34e-07

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000155

Phosphorelay sensor kinase activity

7 of 46

1.69

2.83

2.23e-08

GO:0043565

Sequence-specific DNA binding

6 of 45

1.63

2.45

2.62e-07

GO:0003700

DNA-binding transcription factor activity

6 of 87

1.35

1.62

8.18e-06

GO:0003677

DNA binding

7 of 276

0.91

0.82

0.00024

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009986

Cell surface

6 of 30

1.81

3.03

3.13e-08

GO:0016021

Integral component of membrane

9 of 717

0.61

0.49

0.0011

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:5276

His Kinase A (phosphoacceptor) domain, and Transcriptional regulatory protein, C terminal

8 of 35

1.87

4.06

1.75e-11

CL:5278

His Kinase A (phosphoacceptor) domain, and Transcriptional regulatory protein, C terminal

7 of 27

1.92

3.94

1.71e-10

CL:5283

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain, and PAS fold-4

5 of 10

2.21

3.68

2.43e-08

CL:5280

His Kinase A (phosphoacceptor) domain, and Transcriptional regulatory protein, C terminal

6 of 22

1.94

3.52

5.66e-09

CL:5274

Signaling, and CheY-like superfamily

9 of 64

1.66

3.38

1.75e-11

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map02020

Two-component system

9 of 365

0.9

0.92

7.85e-06

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0418

Kinase

6 of 76

1.41

1.7

1.01e-05

KW-0597

Phosphoprotein

4 of 45

1.46

1.25

0.00094

KW-0175

Coiled coil

5 of 221

0.86

0.55

0.0160

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036097

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain superfamily

7 of 15

2.18

4.71

4.50e-11

IPR004358

Signal transduction histidine kinase-related protein, C-terminal

7 of 15

2.18

4.71

4.50e-11

IPR003661

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain

7 of 15

2.18

4.71

4.50e-11

IPR005467

Histidine kinase domain

7 of 22

2.01

4.23

1.02e-10

IPR003594

Histidine kinase/HSP90-like ATPase

7 of 24

1.97

4.09

1.38e-10

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00388

His Kinase A (phosphoacceptor) domain

8 of 21

2.09

5.36

1.20e-13

SM00387

Histidine kinase-like ATPases

8 of 34

1.88

4.36

1.63e-12

SM00091

PAS domain

3 of 3

2.51

2.56

1.58e-05

SM00086

Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)

3 of 5

2.29

2.32

3.30e-05

SM00448

cheY-homologous receiver domain

3 of 42

1.36

0.94

0.0063

(more ...)

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (30%) [HD]

Permalink

Network

Neighborhood

Experiments

Cooccurrence

Databases

Coexpression

Textmining

Fusion

© STRING Consortium 2024

Credits

Access

Info

About