A0A074Y4U0 protein (Aureobasidium pullulans)

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second shell of interactors

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:

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Gene Fusion

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Coexpression

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[Homology]

Score

A0A074Y4U0

PNPLA domain-containing protein. (474 aa)

Predicted Functional Partners:

A0A074XDB7

0.867

A0A074YSY8

0.854

A0A074XSX6

0.829

A0A074XW40

0.816

A0A074XKJ5

0.815

A0A074XKA2

0.669

A0A074XIY6

0.668

A0A074Y2I7

0.668

A0A074WZ23

0.616

A0A074Y107

0.616

Your Current Organism:

Aureobasidium pullulans

NCBI taxonomy Id: 1043002
Other names: A. pullulans EXF-150, Aureobasidium pullulans EXF-150, Aureobasidium pullulans var. pullulans EXF-150

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A074WZ23	A0A074XDB7	Phospholipase.	Lysophospholipase.	0.850
A0A074WZ23	A0A074XW40	Phospholipase.	Putative vacuolar protein sorting protein Vps66.	0.830
A0A074WZ23	A0A074Y107	Phospholipase.	Phospholipase.	0.826
A0A074WZ23	A0A074Y4U0	Phospholipase.	PNPLA domain-containing protein.	0.616
A0A074WZ23	A0A074YSY8	Phospholipase.	Phospholipid:diacylglycerol acyltransferase.	0.699
A0A074XDB7	A0A074WZ23	Lysophospholipase.	Phospholipase.	0.850
A0A074XDB7	A0A074XKA2	Lysophospholipase.	cAMP-dependent protein kinase regulatory subunit.	0.854
A0A074XDB7	A0A074XKJ5	Lysophospholipase.	Peptidase_M43 domain-containing protein.	0.835
A0A074XDB7	A0A074XSX6	Lysophospholipase.	Lysophospholipase NTE1; Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis.	0.867
A0A074XDB7	A0A074XW40	Lysophospholipase.	Putative vacuolar protein sorting protein Vps66.	0.843
A0A074XDB7	A0A074Y107	Lysophospholipase.	Phospholipase.	0.850
A0A074XDB7	A0A074Y4U0	Lysophospholipase.	PNPLA domain-containing protein.	0.867
A0A074XDB7	A0A074YSY8	Lysophospholipase.	Phospholipid:diacylglycerol acyltransferase.	0.879
A0A074XIY6	A0A074Y4U0	Fatty acid/sphingolipid desaturase.	PNPLA domain-containing protein.	0.668
A0A074XKA2	A0A074XDB7	cAMP-dependent protein kinase regulatory subunit.	Lysophospholipase.	0.854
A0A074XKA2	A0A074XKJ5	cAMP-dependent protein kinase regulatory subunit.	Peptidase_M43 domain-containing protein.	0.672
A0A074XKA2	A0A074XW40	cAMP-dependent protein kinase regulatory subunit.	Putative vacuolar protein sorting protein Vps66.	0.472
A0A074XKA2	A0A074Y4U0	cAMP-dependent protein kinase regulatory subunit.	PNPLA domain-containing protein.	0.669
A0A074XKA2	A0A074YSY8	cAMP-dependent protein kinase regulatory subunit.	Phospholipid:diacylglycerol acyltransferase.	0.721
A0A074XKJ5	A0A074XDB7	Peptidase_M43 domain-containing protein.	Lysophospholipase.	0.835

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

24

average node degree:

4.36

avg. local clustering coefficient:

0.907

expected number of edges:

16

PPI enrichment p-value:

0.0287

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006635

Fatty acid beta-oxidation

9 of 21

2.73

9.81

1.95e-20

GO:0046395

Carboxylic acid catabolic process

11 of 95

2.16

7.64

1.22e-20

GO:0006631

Fatty acid metabolic process

10 of 97

2.11

6.79

2.10e-18

GO:0033540

Fatty acid beta-oxidation using acyl-CoA oxidase

2 of 2

3.09

1.85

0.00046

GO:0010124

Phenylacetate catabolic process

2 of 4

2.79

1.63

0.0011

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016627

Oxidoreductase activity, acting on the CH-CH group of donors

5 of 40

2.19

3.27

2.06e-07

GO:0003988

acetyl-CoA C-acyltransferase activity

3 of 5

2.87

2.62

1.59e-05

GO:0003995

acyl-CoA dehydrogenase activity

3 of 12

2.49

2.29

5.14e-05

GO:0050660

Flavin adenine dinucleotide binding

5 of 130

1.68

1.99

1.88e-05

GO:0052890

Oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor

2 of 2

3.09

1.76

0.00065

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005777

Peroxisome

5 of 88

1.85

2.39

4.57e-06

GO:0005759

Mitochondrial matrix

5 of 173

1.55

1.75

4.00e-05

GO:0005739

Mitochondrion

6 of 758

0.99

0.83

0.0011

GO:0005737

Cytoplasm

11 of 4386

0.49

0.41

0.00075

GO:0043231

Intracellular membrane-bounded organelle

11 of 4419

0.49

0.4

0.00075

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:10406

Fatty acid beta-oxidation, and Oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor

9 of 15

2.87

10.81

6.50e-22

CL:10393

Mixed, incl. Fatty acid metabolic process, and Branched-chain amino acid catabolism

11 of 70

2.29

8.83

2.81e-22

CL:10407

Fatty acid beta-oxidation, and Leucine catabolic process

7 of 10

2.94

8.62

4.05e-17

CL:10394

Mixed, incl. Valine, leucine and isoleucine degradation, and Fatty acid beta-oxidation

10 of 63

2.29

8.28

1.96e-20

CL:10417

Thiolase, C-terminal domain, and Acyl-CoA oxidase

5 of 5

3.09

6.24

3.06e-12

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00071

Fatty acid degradation

8 of 48

2.31

6.74

1.17e-15

map01212

Fatty acid metabolism

7 of 92

1.97

4.35

2.07e-11

map00280

Valine, leucine and isoleucine degradation

6 of 64

2.07

4.17

3.32e-10

map00640

Propanoate metabolism

5 of 53

2.07

3.54

1.98e-08

map00592

alpha-Linolenic acid metabolism

4 of 28

2.25

3.33

1.95e-07

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-390918

Peroxisomal lipid metabolism

5 of 37

2.22

3.58

4.54e-08

MAP-8978868

Fatty acid metabolism

7 of 156

1.75

3.05

8.94e-09

MAP-390247

Beta-oxidation of very long chain fatty acids

3 of 8

2.67

2.66

1.18e-05

MAP-2046106

Alpha-linolenic acid (ALA) metabolism

3 of 10

2.57

2.55

1.71e-05

MAP-2046104

Alpha-linolenic (omega3) and linoleic (omega6) acid metabolism

3 of 10

2.57

2.55

1.71e-05

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005777

Peroxisome

5 of 88

1.85

2.35

5.73e-06

GOCC:0005737

Cytoplasm

9 of 2857

0.59

0.42

0.0093

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0274

FAD

4 of 56

1.95

2.19

2.54e-05

KW-0012

Acyltransferase

3 of 46

1.91

1.61

0.00055

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02770

Acyl-CoA dehydrogenase, middle domain

4 of 8

2.79

3.76

1.05e-07

PF02803

Thiolase, C-terminal domain

3 of 5

2.87

2.73

1.02e-05

PF00108

Thiolase, N-terminal domain

3 of 5

2.87

2.73

1.02e-05

PF02771

Acyl-CoA dehydrogenase, N-terminal domain

3 of 6

2.79

2.71

1.02e-05

PF00441

Acyl-CoA dehydrogenase, C-terminal domain

2 of 4

2.79

1.52

0.0017

(more ...)

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR046373

Acyl-CoA oxidase/dehydrogenase, middle domain superfamily

5 of 9

2.84

4.92

6.29e-10

IPR009100

Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain superfamily

5 of 10

2.79

4.9

6.29e-10

IPR037069

Acyl-CoA dehydrogenase/oxidase, N-terminal domain superfamily

4 of 8

2.79

3.77

1.01e-07

IPR009075

Acyl-CoA dehydrogenase/oxidase C-terminal

4 of 8

2.79

3.77

1.01e-07

IPR036250

Acyl-CoA dehydrogenase-like, C-terminal

4 of 10

2.7

3.69

1.22e-07

(more ...)

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