node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
corC_1 | folP1 | RN50_02251 | RN50_02525 | Magnesium and cobalt efflux protein CorC. | Dihydropteroate synthase 1; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.699 |
dat | folP1 | RN50_01933 | RN50_02525 | D-alanine aminotransferase. | Dihydropteroate synthase 1; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.926 |
dat | trpE | RN50_01933 | RN50_03097 | D-alanine aminotransferase. | Anthranilate synthase component 1. | 0.494 |
dnaK | folE | RN50_00443 | RN50_02526 | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | GTP cyclohydrolase 1. | 0.688 |
dnaK | folP1 | RN50_00443 | RN50_02525 | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | Dihydropteroate synthase 1; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.696 |
dnaK | ftsH | RN50_00443 | RN50_02527 | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | ATP-dependent zinc metalloprotease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | 0.821 |
fgs | folB | RN50_02328 | RN50_02524 | Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | Putative dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 0.841 |
fgs | folE | RN50_02328 | RN50_02526 | Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | GTP cyclohydrolase 1. | 0.864 |
fgs | folK | RN50_02328 | RN50_02523 | Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase. | 0.667 |
fgs | folP1 | RN50_02328 | RN50_02525 | Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | Dihydropteroate synthase 1; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.998 |
fgs | thyA | RN50_02328 | RN50_03040 | Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.937 |
fgs | trpE | RN50_02328 | RN50_03097 | Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | Anthranilate synthase component 1. | 0.500 |
folB | fgs | RN50_02524 | RN50_02328 | Putative dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | 0.841 |
folB | folE | RN50_02524 | RN50_02526 | Putative dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | GTP cyclohydrolase 1. | 0.998 |
folB | folK | RN50_02524 | RN50_02523 | Putative dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase. | 0.999 |
folB | folP1 | RN50_02524 | RN50_02525 | Putative dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | Dihydropteroate synthase 1; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.999 |
folB | ftsH | RN50_02524 | RN50_02527 | Putative dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | ATP-dependent zinc metalloprotease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | 0.941 |
folB | trpE | RN50_02524 | RN50_03097 | Putative dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | Anthranilate synthase component 1. | 0.506 |
folE | dnaK | RN50_02526 | RN50_00443 | GTP cyclohydrolase 1. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.688 |
folE | fgs | RN50_02526 | RN50_02328 | GTP cyclohydrolase 1. | Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | 0.864 |