node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EAG_00786 | EAG_00988 | E2AN89 | E2ALX1 | Crossover junction endonuclease MUS81. | DNA repair protein RAD52-like protein. | 0.896 |
EAG_00786 | EAG_02503 | E2AN89 | E2A6W4 | Crossover junction endonuclease MUS81. | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. | 0.923 |
EAG_00786 | EAG_03394 | E2AN89 | E2AYL1 | Crossover junction endonuclease MUS81. | Serine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family. | 0.756 |
EAG_00786 | EAG_03464 | E2AN89 | E2A0A1 | Crossover junction endonuclease MUS81. | DNA2-like helicase. | 0.864 |
EAG_00786 | EAG_04433 | E2AN89 | E2AZA9 | Crossover junction endonuclease MUS81. | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. | 0.783 |
EAG_00786 | EAG_06985 | E2AN89 | E2AL15 | Crossover junction endonuclease MUS81. | Fanconi anemia group M protein. | 0.891 |
EAG_00786 | EAG_07249 | E2AN89 | E2AMP2 | Crossover junction endonuclease MUS81. | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. | 0.847 |
EAG_00786 | EAG_15013 | E2AN89 | E2AZQ8 | Crossover junction endonuclease MUS81. | DNA repair protein RAD51 homolog; Binds to single and double-stranded DNA and exhibits DNA- dependent ATPase activity. Underwinds duplex DNA. Belongs to the RecA family. RAD51 subfamily. | 0.958 |
EAG_00786 | Fen1 | E2AN89 | E2AQ57 | Crossover junction endonuclease MUS81. | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | 0.854 |
EAG_00988 | EAG_00786 | E2ALX1 | E2AN89 | DNA repair protein RAD52-like protein. | Crossover junction endonuclease MUS81. | 0.896 |
EAG_00988 | EAG_02503 | E2ALX1 | E2A6W4 | DNA repair protein RAD52-like protein. | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. | 0.840 |
EAG_00988 | EAG_03394 | E2ALX1 | E2AYL1 | DNA repair protein RAD52-like protein. | Serine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family. | 0.928 |
EAG_00988 | EAG_03464 | E2ALX1 | E2A0A1 | DNA repair protein RAD52-like protein. | DNA2-like helicase. | 0.893 |
EAG_00988 | EAG_04433 | E2ALX1 | E2AZA9 | DNA repair protein RAD52-like protein. | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. | 0.833 |
EAG_00988 | EAG_06985 | E2ALX1 | E2AL15 | DNA repair protein RAD52-like protein. | Fanconi anemia group M protein. | 0.788 |
EAG_00988 | EAG_07249 | E2ALX1 | E2AMP2 | DNA repair protein RAD52-like protein. | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. | 0.854 |
EAG_00988 | EAG_15013 | E2ALX1 | E2AZQ8 | DNA repair protein RAD52-like protein. | DNA repair protein RAD51 homolog; Binds to single and double-stranded DNA and exhibits DNA- dependent ATPase activity. Underwinds duplex DNA. Belongs to the RecA family. RAD51 subfamily. | 0.995 |
EAG_00988 | Fen1 | E2ALX1 | E2AQ57 | DNA repair protein RAD52-like protein. | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | 0.882 |
EAG_02503 | EAG_00786 | E2A6W4 | E2AN89 | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. | Crossover junction endonuclease MUS81. | 0.923 |
EAG_02503 | EAG_00988 | E2A6W4 | E2ALX1 | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. | DNA repair protein RAD52-like protein. | 0.840 |