STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ESN65390.1Uroporphyrinogen-III C-methyltransferase; KEGG: hemX, uroporphyrinogen III methylase. (378 aa)    
Predicted Functional Partners:
ESN65391.1
KEGG: HemY protein.
 
  
 0.983
ESN65389.1
Uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
 
 0.976
hemC
Hypothetical protein; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
  
 
 0.936
cobA
Uroporphyrinogen-III C-methyltransferase; KEGG: Sirohydrochlorin ferrochelatase.
     
 0.859
cobA-2
KEGG: uroporphyrin-III C-methyltransferase; Belongs to the precorrin methyltransferase family.
     
 0.859
cobA-3
Sirohydrochlorin ferrochelatase, Uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family.
     
 0.859
ESN65387.1
KEGG: cyaA, adenylate cyclase; Belongs to the adenylyl cyclase class-1 family.
 
     0.754
ESN64418.1
KEGG: holA, DNA polymerase III subunit delta.
  
     0.691
lolB
Hypothetical protein; Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein.
  
     0.668
ESN62766.1
Hypothetical protein; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrad [...]
  
     0.664
Your Current Organism:
Serratia sp. ATCC 39006
NCBI taxonomy Id: 104623
Other names: S. sp. ATCC 39006
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