SDF25646.1 protein (Chitinophaga filiformis)

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

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[Homology]

Score

SDF25646.1

Ketosteroid isomerase homolog. (140 aa)

Predicted Functional Partners:

SDG77477.1

0.896

SDF25736.1

0.703

SDF25677.1

0.628

kdsB

0.544

SDH07488.1

0.476

SDG42344.1

0.466

SDH14718.1

0.442

SDH19034.1

0.434

SDH28999.1

0.430

SDG94954.1

0.406

Your Current Organism:

Chitinophaga filiformis

NCBI taxonomy Id: 104663
Other names: ATCC 29495, C. filiformis, CCUG 12809, CIP 106401, DSM 527, Flexibacter filiformis, IFO 15056, JCM 21160, Myxococcus filiformis, NBRC 15056, strain Fx e1 Reichenbach

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SDF25646.1	SDF25677.1	SAMN04488121_1011281	SAMN04488121_1011282	Ketosteroid isomerase homolog.	dTDP-4-amino-4,6-dideoxygalactose transaminase; Belongs to the DegT/DnrJ/EryC1 family.	0.628
SDF25646.1	SDF25736.1	SAMN04488121_1011281	SAMN04488121_1011284	Ketosteroid isomerase homolog.	Alcohol dehydrogenase, class IV.	0.703
SDF25646.1	SDG42344.1	SAMN04488121_1011281	SAMN04488121_104215	Ketosteroid isomerase homolog.	PA domain-containing protein.	0.466
SDF25646.1	SDG77477.1	SAMN04488121_1011281	SAMN04488121_106240	Ketosteroid isomerase homolog.	Beta-aspartyl-peptidase (threonine type).	0.896
SDF25646.1	SDG94954.1	SAMN04488121_1011281	SAMN04488121_107321	Ketosteroid isomerase homolog.	Outer membrane receptor proteins, mostly Fe transport.	0.406
SDF25646.1	SDH07488.1	SAMN04488121_1011281	SAMN04488121_108251	Ketosteroid isomerase homolog.	Outer membrane receptor proteins, mostly Fe transport.	0.476
SDF25646.1	SDH14718.1	SAMN04488121_1011281	SAMN04488121_10981	Ketosteroid isomerase homolog.	Outer membrane receptor proteins, mostly Fe transport.	0.442
SDF25646.1	SDH19034.1	SAMN04488121_1011281	SAMN04488121_109216	Ketosteroid isomerase homolog.	Peptidase family M28.	0.434
SDF25646.1	SDH28999.1	SAMN04488121_1011281	SAMN04488121_110171	Ketosteroid isomerase homolog.	Outer membrane receptor proteins, mostly Fe transport.	0.430
SDF25646.1	kdsB	SAMN04488121_1011281	SAMN04488121_1011283	Ketosteroid isomerase homolog.	3-deoxy-manno-octulosonate cytidylyltransferase (CMP-KDO synthetase); Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.	0.544
SDF25677.1	SDF25646.1	SAMN04488121_1011282	SAMN04488121_1011281	dTDP-4-amino-4,6-dideoxygalactose transaminase; Belongs to the DegT/DnrJ/EryC1 family.	Ketosteroid isomerase homolog.	0.628
SDF25677.1	SDF25736.1	SAMN04488121_1011282	SAMN04488121_1011284	dTDP-4-amino-4,6-dideoxygalactose transaminase; Belongs to the DegT/DnrJ/EryC1 family.	Alcohol dehydrogenase, class IV.	0.931
SDF25677.1	kdsB	SAMN04488121_1011282	SAMN04488121_1011283	dTDP-4-amino-4,6-dideoxygalactose transaminase; Belongs to the DegT/DnrJ/EryC1 family.	3-deoxy-manno-octulosonate cytidylyltransferase (CMP-KDO synthetase); Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.	0.780
SDF25736.1	SDF25646.1	SAMN04488121_1011284	SAMN04488121_1011281	Alcohol dehydrogenase, class IV.	Ketosteroid isomerase homolog.	0.703
SDF25736.1	SDF25677.1	SAMN04488121_1011284	SAMN04488121_1011282	Alcohol dehydrogenase, class IV.	dTDP-4-amino-4,6-dideoxygalactose transaminase; Belongs to the DegT/DnrJ/EryC1 family.	0.931
SDF25736.1	kdsB	SAMN04488121_1011284	SAMN04488121_1011283	Alcohol dehydrogenase, class IV.	3-deoxy-manno-octulosonate cytidylyltransferase (CMP-KDO synthetase); Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.	0.973
SDG42344.1	SDF25646.1	SAMN04488121_104215	SAMN04488121_1011281	PA domain-containing protein.	Ketosteroid isomerase homolog.	0.466
SDG77477.1	SDF25646.1	SAMN04488121_106240	SAMN04488121_1011281	Beta-aspartyl-peptidase (threonine type).	Ketosteroid isomerase homolog.	0.896
SDG94954.1	SDF25646.1	SAMN04488121_107321	SAMN04488121_1011281	Outer membrane receptor proteins, mostly Fe transport.	Ketosteroid isomerase homolog.	0.406
SDH07488.1	SDF25646.1	SAMN04488121_108251	SAMN04488121_1011281	Outer membrane receptor proteins, mostly Fe transport.	Ketosteroid isomerase homolog.	0.476

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Network Stats

number of nodes:

11

number of edges:

33

average node degree:

6

avg. local clustering coefficient:

0.936

expected number of edges:

11

PPI enrichment p-value:

1.13e-07

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006119

Oxidative phosphorylation

6 of 6

2.18

3.75

1.33e-08

GO:0022904

Respiratory electron transport chain

6 of 9

2.0

3.34

3.58e-08

GO:0042773

ATP synthesis coupled electron transport

4 of 4

2.18

2.55

8.30e-06

GO:0022900

Electron transport chain

7 of 34

1.49

2.18

2.30e-07

GO:0006091

Generation of precursor metabolites and energy

8 of 77

1.19

1.49

9.01e-07

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016655

Oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor

6 of 13

1.84

2.85

1.85e-07

GO:0048038

Quinone binding

5 of 10

1.88

2.56

1.90e-06

GO:0050136

NADH dehydrogenase (quinone) activity

5 of 12

1.8

2.4

2.91e-06

GO:0008137

NADH dehydrogenase (ubiquinone) activity

4 of 7

1.93

2.24

1.87e-05

GO:0009055

Electron transfer activity

5 of 15

1.7

2.22

4.13e-06

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0071944

Cell periphery

9 of 280

0.68

0.57

0.00050

GO:0016021

Integral component of membrane

9 of 278

0.69

0.57

0.00050

GO:0005886

Plasma membrane

8 of 250

0.68

0.56

0.00067

GO:0016020

Membrane

10 of 433

0.54

0.45

0.00050

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2214

Mixed, incl. Oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor, and Aerobic electron transport chain

9 of 25

1.73

3.76

4.07e-12

CL:2217

Quinone binding

6 of 11

1.91

3.2

3.65e-08

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00190

Oxidative phosphorylation

8 of 27

1.65

3.14

2.47e-10

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0070069

Cytochrome complex

2 of 2

2.18

0.71

0.0494

GOCC:0016020

Membrane

7 of 252

0.62

0.36

0.0494

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0874

Quinone

4 of 9

1.83

1.91

7.79e-05

KW-0830

Ubiquinone

4 of 10

1.78

1.87

7.79e-05

KW-1278

Translocase

4 of 11

1.74

1.84

7.79e-05

KW-0520

NAD

4 of 30

1.3

1.12

0.0010

KW-1003

Cell membrane

6 of 83

1.04

0.98

0.00020

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00361

Proton-conducting membrane transporter

3 of 3

2.18

1.53

0.0012

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