F3D3_1831 protein (Fusibacter sp. 3D3) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

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[Homology]

Score

F3D3_1831

Hypothetical protein. (86 aa)

Predicted Functional Partners:

F3D3_1829

0.950

F3D3_1830

0.928

F3D3_0515

0.897

F3D3_0743

0.897

F3D3_1972

0.897

F3D3_3259

0.897

F3D3_3526

0.897

F3D3_3732

0.897

F3D3_0516

0.872

F3D3_0744

0.872

Your Current Organism:

Fusibacter sp. 3D3

NCBI taxonomy Id: 1048380
Other names: F. sp. 3D3, Fusibacter sp. 3-D3-R-P8ASC2010, Fusibacter sp. ATCC BAA-2418

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
F3D3_0515	F3D3_0516	Vitamin B12 ABC transporter permease component BtuC; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.	Vitamin B12 ABC transporter B12-binding component BtuF.	0.992
F3D3_0515	F3D3_0744	Vitamin B12 ABC transporter permease component BtuC; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.	Vitamin B12 ABC transporter B12-binding component BtuF.	0.934
F3D3_0515	F3D3_1831	Vitamin B12 ABC transporter permease component BtuC; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.	Hypothetical protein.	0.897
F3D3_0516	F3D3_0515	Vitamin B12 ABC transporter B12-binding component BtuF.	Vitamin B12 ABC transporter permease component BtuC; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.	0.992
F3D3_0516	F3D3_0743	Vitamin B12 ABC transporter B12-binding component BtuF.	Vitamin B12 ABC transporter permease component BtuC; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.	0.924
F3D3_0516	F3D3_1831	Vitamin B12 ABC transporter B12-binding component BtuF.	Hypothetical protein.	0.872
F3D3_0516	F3D3_1972	Vitamin B12 ABC transporter B12-binding component BtuF.	Vitamin B12 ABC transporter, permease component BtuC; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.	0.938
F3D3_0516	F3D3_3259	Vitamin B12 ABC transporter B12-binding component BtuF.	Vitamin B12 ABC transporter; Permease component BtuC; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.	0.936
F3D3_0516	F3D3_3526	Vitamin B12 ABC transporter B12-binding component BtuF.	Vitamin B12 ABC transporter permease component BtuC; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.	0.945
F3D3_0516	F3D3_3732	Vitamin B12 ABC transporter B12-binding component BtuF.	Ferrichrome transport system permease protein FhuB; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.	0.932
F3D3_0743	F3D3_0516	Vitamin B12 ABC transporter permease component BtuC; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.	Vitamin B12 ABC transporter B12-binding component BtuF.	0.924
F3D3_0743	F3D3_0744	Vitamin B12 ABC transporter permease component BtuC; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.	Vitamin B12 ABC transporter B12-binding component BtuF.	0.994
F3D3_0743	F3D3_1831	Vitamin B12 ABC transporter permease component BtuC; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.	Hypothetical protein.	0.897
F3D3_0744	F3D3_0515	Vitamin B12 ABC transporter B12-binding component BtuF.	Vitamin B12 ABC transporter permease component BtuC; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.	0.934
F3D3_0744	F3D3_0743	Vitamin B12 ABC transporter B12-binding component BtuF.	Vitamin B12 ABC transporter permease component BtuC; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.	0.994
F3D3_0744	F3D3_1831	Vitamin B12 ABC transporter B12-binding component BtuF.	Hypothetical protein.	0.872
F3D3_0744	F3D3_1972	Vitamin B12 ABC transporter B12-binding component BtuF.	Vitamin B12 ABC transporter, permease component BtuC; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.	0.934
F3D3_0744	F3D3_3259	Vitamin B12 ABC transporter B12-binding component BtuF.	Vitamin B12 ABC transporter; Permease component BtuC; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.	0.934
F3D3_0744	F3D3_3526	Vitamin B12 ABC transporter B12-binding component BtuF.	Vitamin B12 ABC transporter permease component BtuC; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.	0.934
F3D3_0744	F3D3_3732	Vitamin B12 ABC transporter B12-binding component BtuF.	Ferrichrome transport system permease protein FhuB; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.	0.942

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Network Stats

number of nodes:

11

number of edges:

46

average node degree:

8.36

avg. local clustering coefficient:

0.917

expected number of edges:

14

PPI enrichment p-value:

2.83e-11

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006631

Fatty acid metabolic process

4 of 24

1.61

1.17

0.0030

GO:0019605

Butyrate metabolic process

2 of 2

2.39

0.84

0.0286

GO:0017000

Antibiotic biosynthetic process

3 of 17

1.64

0.77

0.0286

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031177

Phosphopantetheine binding

3 of 3

2.39

1.74

0.00056

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1312

Mixed, incl. AMP-binding enzyme, and Butyrate metabolic process

7 of 10

2.24

5.06

1.07e-11

CL:1286

Mixed, incl. Fatty acid metabolism, and KR domain

8 of 23

1.93

4.31

1.07e-11

CL:1314

AMP-binding enzyme, and Polyketide synthase, ketoreductase domain

3 of 5

2.17

1.84

0.00028

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005777

Peroxisome

4 of 6

2.21

2.6

7.15e-06

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0596

Phosphopantetheine

2 of 4

2.09

0.74

0.0420

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00550

Phosphopantetheine attachment site

5 of 8

2.19

3.27

2.05e-07

PF16197

Ketoacyl-synthetase C-terminal extension

3 of 3

2.39

1.96

0.00021

PF02801

Beta-ketoacyl synthase, C-terminal domain

3 of 4

2.27

1.9

0.00024

PF00109

Beta-ketoacyl synthase, N-terminal domain

3 of 4

2.27

1.9

0.00024

PF00501

AMP-binding enzyme

2 of 4

2.09

0.92

0.0190

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036736

ACP-like superfamily

5 of 8

2.19

3.09

5.38e-07

IPR009081

Phosphopantetheine binding ACP domain

5 of 8

2.19

3.09

5.38e-07

IPR032821

Polyketide synthase, C-terminal extension

3 of 3

2.39

1.83

0.00037

IPR020841

Polyketide synthase, beta-ketoacyl synthase domain

3 of 4

2.27

1.75

0.00048

IPR018201

Beta-ketoacyl synthase, active site

3 of 4

2.27

1.75

0.00048

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00822

This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group.

2 of 2

2.39

1.09

0.0097

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