F3D3_3873 protein (Fusibacter sp. 3D3) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

F3D3_3873

Clostripain. (676 aa)

Predicted Functional Partners:

F3D3_3382

0.938

F3D3_1880

0.870

F3D3_4113

0.842

F3D3_1633

0.841

F3D3_1833

0.841

F3D3_2005

0.833

F3D3_4594

0.823

F3D3_0662

0.816

F3D3_2973

0.794

ribBA

0.791

Your Current Organism:

Fusibacter sp. 3D3

NCBI taxonomy Id: 1048380
Other names: F. sp. 3D3, Fusibacter sp. 3-D3-R-P8ASC2010, Fusibacter sp. ATCC BAA-2418

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
F3D3_0662	F3D3_1633	F3D3_0662	F3D3_1633	Sensory box/GGDEF family protein.	Sensory box/GGDEF family protein.	0.991
F3D3_0662	F3D3_1833	F3D3_0662	F3D3_1833	Sensory box/GGDEF family protein.	Diguanylate cyclase; GGDEF domain with PAS/PAC sensor.	0.991
F3D3_0662	F3D3_1880	F3D3_0662	F3D3_1880	Sensory box/GGDEF family protein.	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.	0.848
F3D3_0662	F3D3_2005	F3D3_0662	F3D3_2005	Sensory box/GGDEF family protein.	Diguanylate cyclase/phosphodiesterase; GGDEF & EAL domains with PAS/PAC sensor.	0.961
F3D3_0662	F3D3_2973	F3D3_0662	F3D3_2973	Sensory box/GGDEF family protein.	Glutamate synthase [NADPH] large chain.	0.685
F3D3_0662	F3D3_3382	F3D3_0662	F3D3_3382	Sensory box/GGDEF family protein.	Serine/threonine protein kinase PrkC; Regulator of stationary phase.	0.889
F3D3_0662	F3D3_3873	F3D3_0662	F3D3_3873	Sensory box/GGDEF family protein.	Clostripain.	0.816
F3D3_0662	F3D3_4594	F3D3_0662	F3D3_4594	Sensory box/GGDEF family protein.	Chemotaxis protein methyltransferase CheR.	0.997
F3D3_0662	ribBA	F3D3_0662	F3D3_0442	Sensory box/GGDEF family protein.	3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family.	0.882
F3D3_1633	F3D3_0662	F3D3_1633	F3D3_0662	Sensory box/GGDEF family protein.	Sensory box/GGDEF family protein.	0.991
F3D3_1633	F3D3_1833	F3D3_1633	F3D3_1833	Sensory box/GGDEF family protein.	Diguanylate cyclase; GGDEF domain with PAS/PAC sensor.	0.900
F3D3_1633	F3D3_2005	F3D3_1633	F3D3_2005	Sensory box/GGDEF family protein.	Diguanylate cyclase/phosphodiesterase; GGDEF & EAL domains with PAS/PAC sensor.	0.947
F3D3_1633	F3D3_2973	F3D3_1633	F3D3_2973	Sensory box/GGDEF family protein.	Glutamate synthase [NADPH] large chain.	0.669
F3D3_1633	F3D3_3873	F3D3_1633	F3D3_3873	Sensory box/GGDEF family protein.	Clostripain.	0.841
F3D3_1633	F3D3_4594	F3D3_1633	F3D3_4594	Sensory box/GGDEF family protein.	Chemotaxis protein methyltransferase CheR.	0.992
F3D3_1633	ribBA	F3D3_1633	F3D3_0442	Sensory box/GGDEF family protein.	3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family.	0.802
F3D3_1833	F3D3_0662	F3D3_1833	F3D3_0662	Diguanylate cyclase; GGDEF domain with PAS/PAC sensor.	Sensory box/GGDEF family protein.	0.991
F3D3_1833	F3D3_1633	F3D3_1833	F3D3_1633	Diguanylate cyclase; GGDEF domain with PAS/PAC sensor.	Sensory box/GGDEF family protein.	0.900
F3D3_1833	F3D3_2005	F3D3_1833	F3D3_2005	Diguanylate cyclase; GGDEF domain with PAS/PAC sensor.	Diguanylate cyclase/phosphodiesterase; GGDEF & EAL domains with PAS/PAC sensor.	0.947
F3D3_1833	F3D3_2973	F3D3_1833	F3D3_2973	Diguanylate cyclase; GGDEF domain with PAS/PAC sensor.	Glutamate synthase [NADPH] large chain.	0.669

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Network Stats

number of nodes:

11

number of edges:

48

average node degree:

8.73

avg. local clustering coefficient:

0.882

expected number of edges:

14

PPI enrichment p-value:

2.36e-12

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006412

Translation

11 of 105

1.18

1.73

1.89e-10

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003735

Structural constituent of ribosome

10 of 54

1.42

2.55

2.74e-11

GO:0019843

rRNA binding

8 of 40

1.46

2.33

9.08e-09

GO:0003723

RNA binding

9 of 99

1.11

1.4

1.28e-07

GO:0003676

Nucleic acid binding

10 of 282

0.7

0.64

3.33e-05

GO:0000049

tRNA binding

3 of 24

1.25

0.63

0.0375

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005840

Ribosome

10 of 57

1.4

2.52

8.87e-12

GO:0015935

Small ribosomal subunit

3 of 7

1.79

1.59

0.00043

GO:0005622

Intracellular anatomical structure

11 of 739

0.33

0.29

0.0029

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:71

Structural constituent of ribosome

7 of 22

1.66

2.97

2.37e-09

CL:67

Ribosomal protein

10 of 49

1.46

2.82

2.24e-12

CL:69

Structural constituent of ribosome

9 of 41

1.5

2.79

3.45e-11

CL:65

Ribosomal protein

11 of 63

1.4

2.63

3.90e-13

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03010

Ribosome

10 of 57

1.4

2.52

9.87e-12

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005840

Ribosome

7 of 45

1.35

1.75

1.41e-06

GOCC:0022626

Cytosolic ribosome

3 of 17

1.4

0.95

0.0066

GOCC:0043229

Intracellular organelle

9 of 181

0.85

0.83

1.66e-05

GOCC:0044391

Ribosomal subunit

3 of 23

1.27

0.79

0.0128

GOCC:0005622

Intracellular

11 of 670

0.37

0.31

0.0026

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0689

Ribosomal protein

10 of 55

1.41

2.56

1.16e-11

KW-0699

rRNA-binding

8 of 39

1.47

2.44

2.71e-09

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