| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| caiE | paaX | A3L23_04710 | A3L23_02297 | Carnitine operon protein CaiE. | Transcriptional repressor PaaX. | 0.409 |
| cobB_1 | paaX | A3L23_03738 | A3L23_02297 | NAD-dependent protein deacetylase; NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form; Belongs to the sirtuin family. Class II subfamily. | Transcriptional repressor PaaX. | 0.538 |
| cobB_2 | paaX | A3L23_03984 | A3L23_02297 | NAD-dependent protein deacylase; Belongs to the sirtuin family. Class III subfamily. | Transcriptional repressor PaaX. | 0.538 |
| cynR_2 | dapE_1 | A3L23_02292 | A3L23_02293 | HTH-type transcriptional regulator CynR; Belongs to the LysR transcriptional regulatory family. | Succinyl-diaminopimelate desuccinylase. | 0.689 |
| cynR_2 | paaX | A3L23_02292 | A3L23_02297 | HTH-type transcriptional regulator CynR; Belongs to the LysR transcriptional regulatory family. | Transcriptional repressor PaaX. | 0.441 |
| cynR_2 | proP_3 | A3L23_02292 | A3L23_02294 | HTH-type transcriptional regulator CynR; Belongs to the LysR transcriptional regulatory family. | Proline/betaine transporter. | 0.504 |
| dapE_1 | cynR_2 | A3L23_02293 | A3L23_02292 | Succinyl-diaminopimelate desuccinylase. | HTH-type transcriptional regulator CynR; Belongs to the LysR transcriptional regulatory family. | 0.689 |
| dapE_1 | kynA | A3L23_02293 | A3L23_02295 | Succinyl-diaminopimelate desuccinylase. | Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. | 0.520 |
| dapE_1 | kynU | A3L23_02293 | A3L23_02296 | Succinyl-diaminopimelate desuccinylase. | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. | 0.524 |
| dapE_1 | paaX | A3L23_02293 | A3L23_02297 | Succinyl-diaminopimelate desuccinylase. | Transcriptional repressor PaaX. | 0.520 |
| dapE_1 | proP_3 | A3L23_02293 | A3L23_02294 | Succinyl-diaminopimelate desuccinylase. | Proline/betaine transporter. | 0.709 |
| kynA | dapE_1 | A3L23_02295 | A3L23_02293 | Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. | Succinyl-diaminopimelate desuccinylase. | 0.520 |
| kynA | kynU | A3L23_02295 | A3L23_02296 | Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. | 0.999 |
| kynA | paaX | A3L23_02295 | A3L23_02297 | Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. | Transcriptional repressor PaaX. | 0.908 |
| kynA | proP_3 | A3L23_02295 | A3L23_02294 | Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. | Proline/betaine transporter. | 0.563 |
| kynU | dapE_1 | A3L23_02296 | A3L23_02293 | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. | Succinyl-diaminopimelate desuccinylase. | 0.524 |
| kynU | kynA | A3L23_02296 | A3L23_02295 | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. | Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. | 0.999 |
| kynU | paaX | A3L23_02296 | A3L23_02297 | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. | Transcriptional repressor PaaX. | 0.906 |
| kynU | proP_3 | A3L23_02296 | A3L23_02294 | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. | Proline/betaine transporter. | 0.571 |
| paaB | paaK | A3L23_02224 | A3L23_02220 | 1,2-phenylacetyl-CoA epoxidase, subunit B. | Phenylacetate-coenzyme A ligase; Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA). | 0.993 |