Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
fumCFumarate hydratase class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (467 aa)    
Predicted Functional Partners:
sdhA
Succinate dehydrogenase flavoprotein subunit.
 0.995
acnA
Aconitate hydratase.
 
 0.985
gltA2
Citrate synthase 1; Belongs to the citrate synthase family.
  
 0.979
AMY54468.1
NAD-dependent malic enzyme.
 
 
 0.976
citA
Putative citrate synthase 2; Belongs to the citrate synthase family.
  
 0.974
sdhB
Succinate dehydrogenase iron-sulfur subunit.
  
 0.969
kgd
Multifunctional 2-oxoglutarate metabolism enzyme.
 
 
 0.966
gabD2
Putative succinate-semialdehyde dehydrogenase [NADP(+)] 2; Belongs to the aldehyde dehydrogenase family.
   
 0.960
sdhC
Succinate dehydrogenase 2 membrane subunit SdhC.
  
 
 0.955
mqo
Putative malate:quinone oxidoreductase.
    
 0.949
Your Current Organism:
Rhodococcus fascians D188
NCBI taxonomy Id: 1051973
Other names: R. fascians D188, Rhodococcus fascians str. D188, Rhodococcus fascians strain D188
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.