KFL_003430015 protein (Klebsormidium nitens)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

KFL_003430015

Uncharacterized protein. (157 aa)

Predicted Functional Partners:

KFL_007010020

0.538

KFL_000850150

0.535

KFL_001870105

0.491

KFL_004130060

0.491

KFL_003900020

0.478

KFL_001330100

0.426

KFL_000020050

0.426

KFL_000320370

0.426

KFL_001340050

0.426

KFL_001690070

0.426

Your Current Organism:

Klebsormidium nitens

NCBI taxonomy Id: 105231
Other names: K. nitens, Klebsormidium nitens (Meneghini) Lokhorst

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KFL_000020050	KFL_000320370	A0A1Y1HGI4	A0A1Y1HQS8	Malate dehydrogenase.	Malate dehydrogenase (NADP+).	0.920
KFL_000020050	KFL_001330100	A0A1Y1HGI4	A0A0U9HJR8	Malate dehydrogenase.	Malate dehydrogenase.	0.861
KFL_000020050	KFL_001340050	A0A1Y1HGI4	A0A1Y1I1J9	Malate dehydrogenase.	Malate dehydrogenase; Belongs to the LDH/MDH superfamily.	0.861
KFL_000020050	KFL_001870105	A0A1Y1HGI4	A0A1Y1I4P1	Malate dehydrogenase.	Uncharacterized protein.	0.426
KFL_000020050	KFL_003430015	A0A1Y1HGI4	A0A0U9I7S4	Malate dehydrogenase.	Uncharacterized protein.	0.426
KFL_000320370	KFL_000020050	A0A1Y1HQS8	A0A1Y1HGI4	Malate dehydrogenase (NADP+).	Malate dehydrogenase.	0.920
KFL_000320370	KFL_001330100	A0A1Y1HQS8	A0A0U9HJR8	Malate dehydrogenase (NADP+).	Malate dehydrogenase.	0.936
KFL_000320370	KFL_001340050	A0A1Y1HQS8	A0A1Y1I1J9	Malate dehydrogenase (NADP+).	Malate dehydrogenase; Belongs to the LDH/MDH superfamily.	0.937
KFL_000320370	KFL_001870105	A0A1Y1HQS8	A0A1Y1I4P1	Malate dehydrogenase (NADP+).	Uncharacterized protein.	0.426
KFL_000320370	KFL_003430015	A0A1Y1HQS8	A0A0U9I7S4	Malate dehydrogenase (NADP+).	Uncharacterized protein.	0.426
KFL_000850150	KFL_001870105	A0A1Y1HWN1	A0A1Y1I4P1	Cation efflux family protein.	Uncharacterized protein.	0.578
KFL_000850150	KFL_003430015	A0A1Y1HWN1	A0A0U9I7S4	Cation efflux family protein.	Uncharacterized protein.	0.535
KFL_000850150	KFL_007010020	A0A1Y1HWN1	A0A1Y1IQK7	Cation efflux family protein.	Cation efflux family protein.	0.620
KFL_001330100	KFL_000020050	A0A0U9HJR8	A0A1Y1HGI4	Malate dehydrogenase.	Malate dehydrogenase.	0.861
KFL_001330100	KFL_000320370	A0A0U9HJR8	A0A1Y1HQS8	Malate dehydrogenase.	Malate dehydrogenase (NADP+).	0.936
KFL_001330100	KFL_001340050	A0A0U9HJR8	A0A1Y1I1J9	Malate dehydrogenase.	Malate dehydrogenase; Belongs to the LDH/MDH superfamily.	0.861
KFL_001330100	KFL_001870105	A0A0U9HJR8	A0A1Y1I4P1	Malate dehydrogenase.	Uncharacterized protein.	0.426
KFL_001330100	KFL_003430015	A0A0U9HJR8	A0A0U9I7S4	Malate dehydrogenase.	Uncharacterized protein.	0.426
KFL_001340050	KFL_000020050	A0A1Y1I1J9	A0A1Y1HGI4	Malate dehydrogenase; Belongs to the LDH/MDH superfamily.	Malate dehydrogenase.	0.861
KFL_001340050	KFL_000320370	A0A1Y1I1J9	A0A1Y1HQS8	Malate dehydrogenase; Belongs to the LDH/MDH superfamily.	Malate dehydrogenase (NADP+).	0.937

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

23

average node degree:

4.18

avg. local clustering coefficient:

0.789

expected number of edges:

10

PPI enrichment p-value:

0.000345

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006084

acetyl-CoA metabolic process

4 of 12

2.07

2.54

6.33e-06

GO:0006086

acetyl-CoA biosynthetic process from pyruvate

3 of 3

2.55

2.45

2.64e-05

GO:0006090

Pyruvate metabolic process

4 of 21

1.83

2.06

3.14e-05

GO:0009150

Purine ribonucleotide metabolic process

7 of 91

1.44

2.0

5.10e-07

GO:0006096

Glycolytic process

3 of 13

1.91

1.66

0.00043

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016624

Oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor

4 of 5

2.45

2.89

3.16e-06

GO:0016417

S-acyltransferase activity

3 of 6

2.25

1.82

0.00034

GO:0004739

Pyruvate dehydrogenase (acetyl-transferring) activity

2 of 3

2.38

1.02

0.0135

GO:0016746

Acyltransferase activity

4 of 133

1.03

0.56

0.0366

GO:0016491

Oxidoreductase activity

6 of 345

0.79

0.5

0.0194

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:1990204

Oxidoreductase complex

6 of 23

1.97

3.55

6.41e-09

GO:0045252

Oxoglutarate dehydrogenase complex

2 of 2

2.55

1.52

0.0016

GO:0005622

Intracellular anatomical structure

10 of 1324

0.43

0.34

0.0038

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1319

Oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor, and 2-oxoacid dehydrogenase acyltransferase, catalytic domain

9 of 14

2.36

7.46

2.93e-17

CL:1318

Mixed, incl. Oxidoreductase complex, and Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain

10 of 22

2.21

7.25

2.37e-18

CL:1321

Oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor, and e3 binding domain

6 of 7

2.48

5.41

1.54e-11

CL:1271

Mixed, incl. Citrate cycle (TCA cycle), and Aldehyde dehydrogenase domain

11 of 66

1.77

4.82

2.93e-17

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00020

Citrate cycle (TCA cycle)

7 of 25

2.0

4.3

4.93e-11

map01200

Carbon metabolism

8 of 115

1.39

2.19

7.27e-09

map00010

Glycolysis / Gluconeogenesis

4 of 37

1.59

1.69

8.26e-05

map00620

Pyruvate metabolism

4 of 49

1.46

1.48

0.00017

map01120

Microbial metabolism in diverse environments

8 of 255

1.05

1.19

2.17e-06

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1222499

Latent infection - Other responses of Mtb to phagocytosis

4 of 47

1.48

1.46

0.00022

MAP-9635486

Infection with Mycobacterium tuberculosis

4 of 94

1.18

0.98

0.0015

MAP-5663205

Infectious disease

4 of 105

1.13

0.94

0.0015

MAP-1643685

Disease

4 of 108

1.12

0.93

0.0015

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:1990204

Oxidoreductase complex

7 of 42

1.77

3.24

2.82e-09

GOCC:0045240

Dihydrolipoyl dehydrogenase complex

3 of 3

2.55

2.41

3.19e-05

GOCC:0045252

Oxoglutarate dehydrogenase complex

2 of 2

2.55

1.46

0.0021

GOCC:0005622

Intracellular

11 of 1295

0.48

0.41

0.00031

GOCC:0005737

Cytoplasm

9 of 978

0.52

0.39

0.0054

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0450

Lipoyl

4 of 4

2.55

3.33

4.85e-07

KW-0324

Glycolysis

2 of 10

1.85

0.78

0.0323

KW-0012

Acyltransferase

3 of 43

1.4

0.74

0.0243

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00198

2-oxoacid dehydrogenases acyltransferase (catalytic domain)

4 of 4

2.55

3.11

1.32e-06

PF00364

Biotin-requiring enzyme

4 of 6

2.38

2.95

1.98e-06

PF02817

e3 binding domain

3 of 3

2.55

2.26

6.19e-05

PF00676

Dehydrogenase E1 component

2 of 2

2.55

1.21

0.0061

PF02780

Transketolase, C-terminal domain

2 of 3

2.38

1.13

0.0081

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR003016

2-oxo acid dehydrogenase, lipoyl-binding site

4 of 4

2.55

2.92

3.21e-06

IPR001078

2-oxoacid dehydrogenase acyltransferase, catalytic domain

4 of 4

2.55

2.92

3.21e-06

IPR011053

Single hybrid motif

4 of 6

2.38

2.85

3.21e-06

IPR000089

Biotin/lipoyl attachment

4 of 6

2.38

2.85

3.21e-06

IPR023213

Chloramphenicol acetyltransferase-like domain superfamily

4 of 8

2.25

2.72

4.51e-06

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00861

Transketolase, pyrimidine binding domain

3 of 4

2.43

2.22

6.66e-05

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (22%) [HD]

Permalink

Network

Neighborhood

Experiments

Cooccurrence

Databases

Coexpression

Textmining

Fusion

© STRING Consortium 2024

Credits

Access

Info

About