KFL_000460160 protein (Klebsormidium nitens)

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second shell of interactors

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Known Interactions

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Predicted Interactions

gene neighborhood

gene fusions

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co-expression

protein homology

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Score

KFL_000460160

Uncharacterized protein. (547 aa)

Predicted Functional Partners:

KFL_003940030

0.826

KFL_011820010

0.785

KFL_001070200

0.774

KFL_004650060

0.727

KFL_004750060

0.727

KFL_009800040

0.727

KFL_006460030

0.727

KFL_008730050

0.727

KFL_001620140

0.724

KFL_000930040

0.722

Your Current Organism:

Klebsormidium nitens

NCBI taxonomy Id: 105231
Other names: K. nitens, Klebsormidium nitens (Meneghini) Lokhorst

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KFL_000460160	KFL_000930040	A0A1Y1HN87	A0A1Y1I165	Uncharacterized protein.	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.722
KFL_000460160	KFL_001070200	A0A1Y1HN87	A0A1Y1HUM0	Uncharacterized protein.	Histone H2A; Belongs to the histone H2A family.	0.774
KFL_000460160	KFL_001620140	A0A1Y1HN87	A0A1Y1HYT5	Uncharacterized protein.	DNA-directed RNA polymerase I subunit 42/43.	0.724
KFL_000460160	KFL_003940030	A0A1Y1HN87	A0A1Y1IDI7	Uncharacterized protein.	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	0.826
KFL_000460160	KFL_004650060	A0A1Y1HN87	A0A1Y1IIF3	Uncharacterized protein.	Uncharacterized protein.	0.727
KFL_000460160	KFL_004750060	A0A1Y1HN87	A0A1Y1IK04	Uncharacterized protein.	PHD domain-containing protein.	0.727
KFL_000460160	KFL_006460030	A0A1Y1HN87	A0A1Y1IPE6	Uncharacterized protein.	Uncharacterized protein.	0.727
KFL_000460160	KFL_008730050	A0A1Y1HN87	A0A1Y1ITA3	Uncharacterized protein.	Uncharacterized protein.	0.727
KFL_000460160	KFL_009800040	A0A1Y1HN87	A0A1Y1IN39	Uncharacterized protein.	PHD-type domain-containing protein.	0.727
KFL_000460160	KFL_011820010	A0A1Y1HN87	A0A1Y1IX89	Uncharacterized protein.	HMG (High mobility group) box protein.	0.785
KFL_000930040	KFL_000460160	A0A1Y1I165	A0A1Y1HN87	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	Uncharacterized protein.	0.722
KFL_000930040	KFL_001070200	A0A1Y1I165	A0A1Y1HUM0	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	Histone H2A; Belongs to the histone H2A family.	0.633
KFL_000930040	KFL_001620140	A0A1Y1I165	A0A1Y1HYT5	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	DNA-directed RNA polymerase I subunit 42/43.	0.999
KFL_000930040	KFL_003940030	A0A1Y1I165	A0A1Y1IDI7	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	0.670
KFL_000930040	KFL_011820010	A0A1Y1I165	A0A1Y1IX89	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	HMG (High mobility group) box protein.	0.754
KFL_001070200	KFL_000460160	A0A1Y1HUM0	A0A1Y1HN87	Histone H2A; Belongs to the histone H2A family.	Uncharacterized protein.	0.774
KFL_001070200	KFL_000930040	A0A1Y1HUM0	A0A1Y1I165	Histone H2A; Belongs to the histone H2A family.	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.633
KFL_001070200	KFL_001620140	A0A1Y1HUM0	A0A1Y1HYT5	Histone H2A; Belongs to the histone H2A family.	DNA-directed RNA polymerase I subunit 42/43.	0.825
KFL_001070200	KFL_003940030	A0A1Y1HUM0	A0A1Y1IDI7	Histone H2A; Belongs to the histone H2A family.	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	0.994
KFL_001070200	KFL_004650060	A0A1Y1HUM0	A0A1Y1IIF3	Histone H2A; Belongs to the histone H2A family.	Uncharacterized protein.	0.633

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Network Stats

number of nodes:

11

number of edges:

39

average node degree:

7.09

avg. local clustering coefficient:

0.919

expected number of edges:

12

PPI enrichment p-value:

2.84e-10

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0017148

Negative regulation of translation

7 of 38

2.15

4.88

1.05e-11

GO:0000288

Nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

6 of 27

2.23

4.51

2.67e-10

GO:0006401

RNA catabolic process

9 of 96

1.86

4.33

9.40e-13

GO:0006402

mRNA catabolic process

8 of 76

1.91

4.27

7.63e-12

GO:0000956

Nuclear-transcribed mRNA catabolic process

7 of 71

1.88

3.75

3.17e-10

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004535

poly(A)-specific ribonuclease activity

3 of 4

2.76

2.23

8.28e-05

GO:0140098

Catalytic activity, acting on RNA

5 of 239

1.2

0.99

0.0016

GO:0003723

RNA binding

6 of 528

0.94

0.71

0.0035

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030015

CCR4-NOT core complex

6 of 6

2.88

6.45

6.98e-13

GO:0000932

P-body

6 of 29

2.2

4.39

4.04e-10

GO:0043232

Intracellular non-membrane-bounded organelle

7 of 988

0.73

0.52

0.0068

GO:0005634

Nucleus

9 of 2032

0.53

0.39

0.0078

GO:0032991

Protein-containing complex

8 of 1698

0.56

0.37

0.0188

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:5685

CCR4-NOT core complex

5 of 5

2.88

5.31

1.20e-10

CL:5630

Mixed, incl. CCR4-NOT core complex, and RNA recognition motif

7 of 34

2.2

4.9

1.79e-11

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03018

RNA degradation

10 of 84

1.96

5.78

2.99e-17

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-6804115

TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain

5 of 7

2.74

4.93

4.71e-10

MAP-6791312

TP53 Regulates Transcription of Cell Cycle Genes

5 of 7

2.74

4.93

4.71e-10

MAP-429914

Deadenylation-dependent mRNA decay

7 of 41

2.12

4.62

3.65e-11

MAP-3700989

Transcriptional Regulation by TP53

5 of 149

1.41

1.46

0.00012

MAP-212436

Generic Transcription Pathway

6 of 230

1.3

1.44

3.40e-05

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0030014

CCR4-NOT complex

7 of 8

2.83

7.54

3.45e-15

GOCC:0030015

CCR4-NOT core complex

2 of 2

2.88

1.3

0.0045

GOCC:0032991

Protein-containing complex

9 of 2023

0.53

0.34

0.0298

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