KFL_000130430 protein (Klebsormidium nitens)

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second shell of interactors

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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Score

KFL_000130430

Putative DNA repair protein XPGC. (1107 aa)

Predicted Functional Partners:

KFL_003810040

0.998

KFL_001210170

0.976

KFL_003570040

0.973

KFL_006980030

0.954

KFL_006490050

0.944

KFL_000490340

0.927

KFL_002110150

0.911

KFL_000460010

0.904

KFL_002030160

0.904

KFL_003260090

0.903

Your Current Organism:

Klebsormidium nitens

NCBI taxonomy Id: 105231
Other names: K. nitens, Klebsormidium nitens (Meneghini) Lokhorst

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KFL_000130430	KFL_000460010	A0A1Y1HN98	A0A1Y1HW69	Putative DNA repair protein XPGC.	Pre-initiation complex subunit CDC6.	0.904
KFL_000130430	KFL_000490340	A0A1Y1HN98	A0A0U9HQB4	Putative DNA repair protein XPGC.	Putative Y-family DNA polymerase.	0.927
KFL_000130430	KFL_001210170	A0A1Y1HN98	A0A1Y1HVS1	Putative DNA repair protein XPGC.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.976
KFL_000130430	KFL_002030160	A0A1Y1HN98	A0A1Y1I1E8	Putative DNA repair protein XPGC.	DNA helicase.	0.904
KFL_000130430	KFL_002110150	A0A1Y1HN98	A0A1Y1I869	Putative DNA repair protein XPGC.	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	0.911
KFL_000130430	KFL_003260090	A0A1Y1HN98	A0A1Y1IE91	Putative DNA repair protein XPGC.	Protein kinase of the PI-3 kinase family; Belongs to the PI3/PI4-kinase family.	0.903
KFL_000130430	KFL_003570040	A0A1Y1HN98	A0A1Y1I943	Putative DNA repair protein XPGC.	DNA mismatch repair protein-MLH1 family.	0.973
KFL_000130430	KFL_003810040	A0A1Y1HN98	A0A1Y1IA94	Putative DNA repair protein XPGC.	Helicase conserved C-terminal domain containing protein.	0.998
KFL_000130430	KFL_006490050	A0A1Y1HN98	A0A1Y1IHZ5	Putative DNA repair protein XPGC.	DNA replication helicase 2.	0.944
KFL_000130430	KFL_006980030	A0A1Y1HN98	A0A1Y1IJ60	Putative DNA repair protein XPGC.	DNA ligase.	0.954
KFL_000460010	KFL_000130430	A0A1Y1HW69	A0A1Y1HN98	Pre-initiation complex subunit CDC6.	Putative DNA repair protein XPGC.	0.904
KFL_000460010	KFL_000490340	A0A1Y1HW69	A0A0U9HQB4	Pre-initiation complex subunit CDC6.	Putative Y-family DNA polymerase.	0.638
KFL_000460010	KFL_003260090	A0A1Y1HW69	A0A1Y1IE91	Pre-initiation complex subunit CDC6.	Protein kinase of the PI-3 kinase family; Belongs to the PI3/PI4-kinase family.	0.861
KFL_000460010	KFL_003810040	A0A1Y1HW69	A0A1Y1IA94	Pre-initiation complex subunit CDC6.	Helicase conserved C-terminal domain containing protein.	0.507
KFL_000460010	KFL_006490050	A0A1Y1HW69	A0A1Y1IHZ5	Pre-initiation complex subunit CDC6.	DNA replication helicase 2.	0.484
KFL_000460010	KFL_006980030	A0A1Y1HW69	A0A1Y1IJ60	Pre-initiation complex subunit CDC6.	DNA ligase.	0.556
KFL_000490340	KFL_000130430	A0A0U9HQB4	A0A1Y1HN98	Putative Y-family DNA polymerase.	Putative DNA repair protein XPGC.	0.927
KFL_000490340	KFL_000460010	A0A0U9HQB4	A0A1Y1HW69	Putative Y-family DNA polymerase.	Pre-initiation complex subunit CDC6.	0.638
KFL_000490340	KFL_001210170	A0A0U9HQB4	A0A1Y1HVS1	Putative Y-family DNA polymerase.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.703
KFL_000490340	KFL_002030160	A0A0U9HQB4	A0A1Y1I1E8	Putative Y-family DNA polymerase.	DNA helicase.	0.595

page 1 of 5

Network Stats

number of nodes:

2

number of edges:

1

average node degree:

1

avg. local clustering coefficient:

1

expected number of edges:

1

PPI enrichment p-value:

0.5

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0019509

L-methionine salvage from methylthioadenosine

5 of 10

2.78

4.68

1.65e-09

GO:0019284

L-methionine salvage from S-adenosylmethionine

3 of 6

2.78

2.69

1.12e-05

GO:0044283

Small molecule biosynthetic process

6 of 545

1.12

1.03

0.00041

GO:0005996

Monosaccharide metabolic process

3 of 129

1.45

0.78

0.0220

GO:0019752

Carboxylic acid metabolic process

6 of 788

0.96

0.75

0.0026

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0043874

Acireductone synthase activity

2 of 2

3.08

1.18

0.0074

GO:0043716

2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase activity

2 of 2

3.08

1.18

0.0074

GO:0043715

2,3-diketo-5-methylthiopentyl-1-phosphate enolase activity

2 of 2

3.08

1.18

0.0074

GO:0010309

Acireductone dioxygenase [iron(II)-requiring] activity

2 of 2

3.08

1.18

0.0074

GO:0010308

Acireductone dioxygenase (Ni2+-requiring) activity

2 of 2

3.08

1.18

0.0074

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:20301

Amino acid salvage, and ribitol-5-phosphatase activity

7 of 12

2.85

7.61

2.79e-15

CL:20303

L-methionine salvage from S-adenosylmethionine, and Acireductone dioxygenase ARD family

3 of 6

2.78

2.59

1.73e-05

CL:16299

Glycolytic process, and Pentose phosphate pathway

4 of 59

1.91

2.02

6.01e-05

CL:16407

Mixed, incl. Ribokinase, and Xylulose metabolic process

2 of 5

2.68

1.37

0.0032

CL:16313

Glycolytic process

2 of 19

2.1

0.86

0.0244

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00270

Cysteine and methionine metabolism

6 of 108

1.83

3.1

2.45e-08

map01100

Metabolic pathways

11 of 3633

0.56

0.49

5.09e-05

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1237112

Methionine salvage pathway

5 of 7

2.94

5.37

1.03e-10

MAP-1614635

Sulfur amino acid metabolism

5 of 36

2.22

3.57

4.81e-08

MAP-71291

Metabolism of amino acids and derivatives

5 of 400

1.18

0.91

0.0030

MAP-71387

Metabolism of carbohydrates

4 of 333

1.16

0.67

0.0227

MAP-1430728

Metabolism

9 of 2436

0.65

0.49

0.0030

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0486

Methionine biosynthesis

3 of 8

2.66

2.57

1.75e-05

KW-0223

Dioxygenase

2 of 9

2.43

1.37

0.0029

KW-0119

Carbohydrate metabolism

2 of 17

2.15

1.16

0.0067

KW-0963

Cytoplasm

3 of 180

1.3

0.75

0.0197

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR027496

Acireductone dioxygenase, eukaryotes

2 of 2

3.08

0.96

0.0186

IPR004313

Acireductone dioxygenase ARD family

2 of 2

3.08

0.96

0.0186

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