KFL_000020790 protein (Klebsormidium nitens)

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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Score

KFL_000020790

Guanylate cyclase domain-containing protein. (92 aa)

Predicted Functional Partners:

KFL_001800030

0.872

KFL_007590040

0.872

KFL_001330050

0.866

KFL_000160260

0.748

KFL_000010350

0.700

KFL_001960100

0.700

KFL_002670040

0.700

KFL_008660040

0.699

KFL_002090070

0.696

KFL_003350120

0.691

Your Current Organism:

Klebsormidium nitens

NCBI taxonomy Id: 105231
Other names: K. nitens, Klebsormidium nitens (Meneghini) Lokhorst

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KFL_000010350	KFL_000020790	A0A0U9HHT7	A0A1Y1HPH2	Phosphodiesterase.	Guanylate cyclase domain-containing protein.	0.700
KFL_000010350	KFL_001330050	A0A0U9HHT7	A0A0U9HKE2	Phosphodiesterase.	AGC (cAMP-dependent, cGMP-dependent and protein kinase C) kinase family protein.	0.936
KFL_000010350	KFL_003350120	A0A0U9HHT7	A0A0U9HTH3	Phosphodiesterase.	G-protein alpha subunit.	0.729
KFL_000010350	KFL_008660040	A0A0U9HHT7	A0A1Y1IMH6	Phosphodiesterase.	G protein beta subunit.	0.768
KFL_000020790	KFL_000010350	A0A1Y1HPH2	A0A0U9HHT7	Guanylate cyclase domain-containing protein.	Phosphodiesterase.	0.700
KFL_000020790	KFL_000160260	A0A1Y1HPH2	A0A1Y1HKY1	Guanylate cyclase domain-containing protein.	WD_REPEATS_REGION domain-containing protein.	0.748
KFL_000020790	KFL_001330050	A0A1Y1HPH2	A0A0U9HKE2	Guanylate cyclase domain-containing protein.	AGC (cAMP-dependent, cGMP-dependent and protein kinase C) kinase family protein.	0.866
KFL_000020790	KFL_001800030	A0A1Y1HPH2	A0A1Y1HZW1	Guanylate cyclase domain-containing protein.	Putative Endoribonuclease.	0.872
KFL_000020790	KFL_001960100	A0A1Y1HPH2	A0A1Y1I296	Guanylate cyclase domain-containing protein.	Cyclic GMP phosphodiesterase; Belongs to the cyclic nucleotide phosphodiesterase family.	0.700
KFL_000020790	KFL_002090070	A0A1Y1HPH2	A0A1Y1I1R0	Guanylate cyclase domain-containing protein.	Adenylyl cyclase-associated protein; Belongs to the CAP family.	0.696
KFL_000020790	KFL_002670040	A0A1Y1HPH2	A0A1Y1I6A5	Guanylate cyclase domain-containing protein.	Phosphodiesterase.	0.700
KFL_000020790	KFL_003350120	A0A1Y1HPH2	A0A0U9HTH3	Guanylate cyclase domain-containing protein.	G-protein alpha subunit.	0.691
KFL_000020790	KFL_007590040	A0A1Y1HPH2	A0A1Y1IKB6	Guanylate cyclase domain-containing protein.	Diphthami_syn_2 domain-containing protein.	0.872
KFL_000020790	KFL_008660040	A0A1Y1HPH2	A0A1Y1IMH6	Guanylate cyclase domain-containing protein.	G protein beta subunit.	0.699
KFL_000160260	KFL_000020790	A0A1Y1HKY1	A0A1Y1HPH2	WD_REPEATS_REGION domain-containing protein.	Guanylate cyclase domain-containing protein.	0.748
KFL_000160260	KFL_001330050	A0A1Y1HKY1	A0A0U9HKE2	WD_REPEATS_REGION domain-containing protein.	AGC (cAMP-dependent, cGMP-dependent and protein kinase C) kinase family protein.	0.409
KFL_000160260	KFL_008660040	A0A1Y1HKY1	A0A1Y1IMH6	WD_REPEATS_REGION domain-containing protein.	G protein beta subunit.	0.624
KFL_001330050	KFL_000010350	A0A0U9HKE2	A0A0U9HHT7	AGC (cAMP-dependent, cGMP-dependent and protein kinase C) kinase family protein.	Phosphodiesterase.	0.936
KFL_001330050	KFL_000020790	A0A0U9HKE2	A0A1Y1HPH2	AGC (cAMP-dependent, cGMP-dependent and protein kinase C) kinase family protein.	Guanylate cyclase domain-containing protein.	0.866
KFL_001330050	KFL_000160260	A0A0U9HKE2	A0A1Y1HKY1	AGC (cAMP-dependent, cGMP-dependent and protein kinase C) kinase family protein.	WD_REPEATS_REGION domain-containing protein.	0.409

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

40

average node degree:

7.27

avg. local clustering coefficient:

0.827

expected number of edges:

15

PPI enrichment p-value:

5.98e-08

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0014065

Phosphatidylinositol 3-kinase signaling

5 of 19

2.5

4.15

8.63e-09

GO:0048015

Phosphatidylinositol-mediated signaling

6 of 42

2.23

3.94

6.80e-09

GO:0046854

Phosphatidylinositol phosphate biosynthetic process

6 of 50

2.15

3.84

6.80e-09

GO:0046488

Phosphatidylinositol metabolic process

7 of 119

1.85

3.3

6.80e-09

GO:0051896

Regulation of protein kinase B signaling

5 of 64

1.97

2.8

7.92e-07

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016303

1-phosphatidylinositol-3-kinase activity

5 of 8

2.87

5.01

4.54e-10

GO:0052812

phosphatidylinositol-3,4-bisphosphate 5-kinase activity

4 of 5

2.98

4.18

2.08e-08

GO:0035005

1-phosphatidylinositol-4-phosphate 3-kinase activity

4 of 7

2.83

4.01

3.63e-08

GO:0008384

IkappaB kinase activity

2 of 2

3.08

1.83

0.00050

GO:0043560

Insulin receptor substrate binding

2 of 3

2.9

1.76

0.00063

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005942

Phosphatidylinositol 3-kinase complex

6 of 26

2.44

5.04

7.42e-11

GO:0097651

Phosphatidylinositol 3-kinase complex, class I

4 of 5

2.98

4.27

1.41e-08

GO:0061695

Transferase complex, transferring phosphorus-containing groups

8 of 178

1.73

3.43

1.41e-10

GO:0019898

Extrinsic component of membrane

7 of 190

1.64

2.75

1.53e-08

GO:0008385

IkappaB kinase complex

2 of 3

2.9

1.68

0.00089

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2747

Phosphatidylinositol 3-kinase complex, class I, and PI3K p85 subunit, N-terminal SH2 domain

5 of 10

2.77

4.75

1.17e-09

CL:2749

PI3K/AKT activation, and Phosphatidylinositol trisphosphate phosphatase activity

3 of 5

2.85

2.74

9.59e-06

CL:3314

IkappaB kinase activity, and NF-kappa-B/Dorsal

2 of 5

2.68

1.33

0.0037

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04068

FoxO signaling pathway

8 of 118

1.91

4.44

1.82e-12

map04625

C-type lectin receptor signaling pathway

6 of 63

2.05

4.04

7.21e-10

map04620

Toll-like receptor signaling pathway

6 of 70

2.01

3.94

7.21e-10

map00562

Inositol phosphate metabolism

6 of 86

1.92

3.63

1.77e-09

map04370

VEGF signaling pathway

5 of 54

2.04

3.59

1.14e-08

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1483255

PI Metabolism

7 of 83

2.0

4.06

2.97e-10

MAP-1660499

Synthesis of PIPs at the plasma membrane

6 of 56

2.11

3.89

3.21e-09

MAP-912631

Regulation of signaling by CBL

4 of 17

2.45

3.22

6.46e-07

MAP-198203

PI3K/AKT activation

3 of 3

3.08

3.21

1.42e-06

MAP-114604

GPVI-mediated activation cascade

4 of 22

2.34

3.06

1.07e-06

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005942

Phosphatidylinositol 3-kinase complex

4 of 17

2.45

2.96

2.21e-06

GOCC:0061695

Transferase complex, transferring phosphorus-containing groups

6 of 188

1.58

2.09

2.93e-06

GOCC:0097651

Phosphatidylinositol 3-kinase complex, class I

2 of 3

2.9

1.51

0.0018

GOCC:0008385

IkappaB kinase complex

2 of 4

2.77

1.46

0.0022

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0418

Kinase

9 of 562

1.28

1.89

7.89e-09

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR042236

Phosphoinositide 3-kinase, accessory (PIK) domain superfamily

5 of 8

2.87

4.85

9.26e-10

IPR015433

Phosphatidylinositol kinase

5 of 8

2.87

4.85

9.26e-10

IPR001263

Phosphoinositide 3-kinase, accessory (PIK) domain

5 of 8

2.87

4.85

9.26e-10

IPR036940

Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily

5 of 12

2.7

4.72

1.11e-09

IPR018936

Phosphatidylinositol 3/4-kinase, conserved site

5 of 12

2.7

4.72

1.11e-09

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00145

Phosphoinositide 3-kinase family, accessory domain (PIK domain)

5 of 8

2.87

5.31

1.19e-10

SM00146

Phosphoinositide 3-kinase, catalytic domain

5 of 12

2.7

5.01

2.85e-10

SM00144

PI3-kinase family, Ras-binding domain

4 of 7

2.83

4.15

1.90e-08

SM00143

PI3-kinase family, p85-binding domain

3 of 3

3.08

3.21

1.42e-06

SM00142

Phosphoinositide 3-kinase, region postulated to contain C2 domain

3 of 4

2.95

3.12

1.98e-06

(more ...)

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