node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
FEN1 | KFL_000220250 | A0A1Y1HUF1 | A0A1Y1HK96 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Replication factor C subunit RFC4. | 0.874 |
FEN1 | KFL_000490340 | A0A1Y1HUF1 | A0A0U9HQB4 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Putative Y-family DNA polymerase. | 0.708 |
FEN1 | KFL_000690130 | A0A1Y1HUF1 | A0A1Y1HT81 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | AAA domain-containing protein. | 0.799 |
FEN1 | KFL_000860170 | A0A1Y1HUF1 | A0A1Y1HSP2 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Checkpoint RAD17-RFC complex RAD17/RAD24 component. | 0.786 |
FEN1 | KFL_001300130 | A0A1Y1HUF1 | A0A1Y1HWC7 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Replication factor C subunit RFC3. | 0.880 |
FEN1 | KFL_003550040 | A0A1Y1HUF1 | A0A1Y1I911 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Replication factor C subunit RFC5. | 0.815 |
FEN1 | KFL_003730140 | A0A1Y1HUF1 | A0A1Y1IG51 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Replication factor C subunit RFC2. | 0.847 |
FEN1 | KFL_003810040 | A0A1Y1HUF1 | A0A1Y1IA94 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Helicase conserved C-terminal domain containing protein. | 0.998 |
FEN1 | KFL_004220150 | A0A1Y1HUF1 | A0A1Y1II98 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. | 0.778 |
FEN1 | KFL_006980030 | A0A1Y1HUF1 | A0A1Y1IJ60 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | DNA ligase. | 0.979 |
KFL_000220250 | FEN1 | A0A1Y1HK96 | A0A1Y1HUF1 | Replication factor C subunit RFC4. | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | 0.874 |
KFL_000220250 | KFL_000490340 | A0A1Y1HK96 | A0A0U9HQB4 | Replication factor C subunit RFC4. | Putative Y-family DNA polymerase. | 0.994 |
KFL_000220250 | KFL_000690130 | A0A1Y1HK96 | A0A1Y1HT81 | Replication factor C subunit RFC4. | AAA domain-containing protein. | 0.888 |
KFL_000220250 | KFL_000860170 | A0A1Y1HK96 | A0A1Y1HSP2 | Replication factor C subunit RFC4. | Checkpoint RAD17-RFC complex RAD17/RAD24 component. | 0.999 |
KFL_000220250 | KFL_001300130 | A0A1Y1HK96 | A0A1Y1HWC7 | Replication factor C subunit RFC4. | Replication factor C subunit RFC3. | 0.999 |
KFL_000220250 | KFL_003550040 | A0A1Y1HK96 | A0A1Y1I911 | Replication factor C subunit RFC4. | Replication factor C subunit RFC5. | 0.999 |
KFL_000220250 | KFL_003730140 | A0A1Y1HK96 | A0A1Y1IG51 | Replication factor C subunit RFC4. | Replication factor C subunit RFC2. | 0.999 |
KFL_000220250 | KFL_003810040 | A0A1Y1HK96 | A0A1Y1IA94 | Replication factor C subunit RFC4. | Helicase conserved C-terminal domain containing protein. | 0.989 |
KFL_000220250 | KFL_004220150 | A0A1Y1HK96 | A0A1Y1II98 | Replication factor C subunit RFC4. | DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. | 0.928 |
KFL_000220250 | KFL_006980030 | A0A1Y1HK96 | A0A1Y1IJ60 | Replication factor C subunit RFC4. | DNA ligase. | 0.958 |