KFL_001650150 protein (Klebsormidium nitens)

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

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Score

KFL_001650150

Iron-sulphur cluster biosynthesis family protein. (620 aa)

Predicted Functional Partners:

KFL_000720280

0.907

KFL_000180270

0.831

KFL_001670050

0.820

KFL_004960060

0.820

KFL_007700020

0.701

KFL_000610430

0.660

KFL_000240220

0.660

KFL_001440310

0.660

KFL_004890080

0.660

KFL_004270110

0.660

Your Current Organism:

Klebsormidium nitens

NCBI taxonomy Id: 105231
Other names: K. nitens, Klebsormidium nitens (Meneghini) Lokhorst

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KFL_000180270	KFL_000240220	A0A1Y1HJM2	A0A1Y1HQ30	DnaJ heat shock family protein.	Glutaredoxin domain-containing protein.	0.664
KFL_000180270	KFL_000610430	A0A1Y1HJM2	A0A0U9HIQ7	DnaJ heat shock family protein.	Glutaredoxin; Belongs to the glutaredoxin family. Monothiol subfamily.	0.665
KFL_000180270	KFL_000720280	A0A1Y1HJM2	A0A1Y1HVD6	DnaJ heat shock family protein.	Iron-sulfur cluster assembly protein; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins.	0.997
KFL_000180270	KFL_001440310	A0A1Y1HJM2	A0A1Y1HXF7	DnaJ heat shock family protein.	Glutaredoxin-related protein.	0.638
KFL_000180270	KFL_001650150	A0A1Y1HJM2	A0A1Y1I1M6	DnaJ heat shock family protein.	Iron-sulphur cluster biosynthesis family protein.	0.831
KFL_000180270	KFL_001670050	A0A1Y1HJM2	A0A1Y1HZ13	DnaJ heat shock family protein.	Iron-sulphur cluster biosynthesis family protein.	0.839
KFL_000180270	KFL_004270110	A0A1Y1HJM2	A0A1Y1IH97	DnaJ heat shock family protein.	Glutaredoxin domain-containing protein.	0.664
KFL_000180270	KFL_004890080	A0A1Y1HJM2	A0A1Y1IDT5	DnaJ heat shock family protein.	Uncharacterized protein.	0.638
KFL_000180270	KFL_004960060	A0A1Y1HJM2	A0A1Y1IKA4	DnaJ heat shock family protein.	Iron-sulphur cluster biosynthesis family protein.	0.839
KFL_000240220	KFL_000180270	A0A1Y1HQ30	A0A1Y1HJM2	Glutaredoxin domain-containing protein.	DnaJ heat shock family protein.	0.664
KFL_000240220	KFL_000720280	A0A1Y1HQ30	A0A1Y1HVD6	Glutaredoxin domain-containing protein.	Iron-sulfur cluster assembly protein; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins.	0.409
KFL_000240220	KFL_001650150	A0A1Y1HQ30	A0A1Y1I1M6	Glutaredoxin domain-containing protein.	Iron-sulphur cluster biosynthesis family protein.	0.660
KFL_000240220	KFL_001670050	A0A1Y1HQ30	A0A1Y1HZ13	Glutaredoxin domain-containing protein.	Iron-sulphur cluster biosynthesis family protein.	0.694
KFL_000240220	KFL_004960060	A0A1Y1HQ30	A0A1Y1IKA4	Glutaredoxin domain-containing protein.	Iron-sulphur cluster biosynthesis family protein.	0.694
KFL_000610430	KFL_000180270	A0A0U9HIQ7	A0A1Y1HJM2	Glutaredoxin; Belongs to the glutaredoxin family. Monothiol subfamily.	DnaJ heat shock family protein.	0.665
KFL_000610430	KFL_000720280	A0A0U9HIQ7	A0A1Y1HVD6	Glutaredoxin; Belongs to the glutaredoxin family. Monothiol subfamily.	Iron-sulfur cluster assembly protein; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins.	0.409
KFL_000610430	KFL_001650150	A0A0U9HIQ7	A0A1Y1I1M6	Glutaredoxin; Belongs to the glutaredoxin family. Monothiol subfamily.	Iron-sulphur cluster biosynthesis family protein.	0.660
KFL_000610430	KFL_001670050	A0A0U9HIQ7	A0A1Y1HZ13	Glutaredoxin; Belongs to the glutaredoxin family. Monothiol subfamily.	Iron-sulphur cluster biosynthesis family protein.	0.694
KFL_000610430	KFL_004960060	A0A0U9HIQ7	A0A1Y1IKA4	Glutaredoxin; Belongs to the glutaredoxin family. Monothiol subfamily.	Iron-sulphur cluster biosynthesis family protein.	0.808
KFL_000720280	KFL_000180270	A0A1Y1HVD6	A0A1Y1HJM2	Iron-sulfur cluster assembly protein; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins.	DnaJ heat shock family protein.	0.997

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Network Stats

number of nodes:

11

number of edges:

34

average node degree:

6.18

avg. local clustering coefficient:

0.72

expected number of edges:

11

PPI enrichment p-value:

2.98e-08

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0042273

Ribosomal large subunit biogenesis

7 of 58

2.06

4.23

2.26e-10

GO:0000054

Ribosomal subunit export from nucleus

4 of 16

2.38

2.97

1.79e-06

GO:0042254

Ribosome biogenesis

9 of 241

1.55

2.86

2.26e-10

GO:0042255

Ribosome assembly

4 of 32

2.08

2.4

1.35e-05

GO:0000027

Ribosomal large subunit assembly

3 of 16

2.26

1.98

0.00016

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0043023

Ribosomal large subunit binding

2 of 7

2.44

0.74

0.0451

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030687

Preribosome, large subunit precursor

3 of 23

2.1

1.6

0.00079

GO:0005730

Nucleolus

5 of 197

1.39

1.23

0.00075

GO:1990904

Ribonucleoprotein complex

4 of 350

1.04

0.61

0.0241

GO:0043232

Intracellular non-membrane-bounded organelle

6 of 862

0.83

0.55

0.0119

GO:0005634

Nucleus

8 of 1734

0.65

0.45

0.0101

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:4429

Ribosomal large subunit biogenesis, and Nucleolar protein,Nop52

10 of 44

2.34

8.3

7.20e-20

CL:4433

Ribosomal large subunit biogenesis, and GTP-binding protein, orthogonal bundle domain superfamily

6 of 32

2.26

4.75

8.55e-11

CL:4483

Mixed, incl. Ribosomal protein S8e, and Ribosomal protein L24e

3 of 5

2.76

2.87

5.13e-06

CL:4442

Ribosome biogenesis

2 of 5

2.58

1.46

0.0021

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03008

Ribosome biogenesis in eukaryotes

6 of 69

1.92

3.46

6.58e-09

map03010

Ribosome

3 of 153

1.27

0.65

0.0336

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005730

Nucleolus

3 of 86

1.53

0.68

0.0406

GOCC:0043232

Intracellular non-membrane-bounded organelle

6 of 758

0.88

0.49

0.0406

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0690

Ribosome biogenesis

3 of 17

2.23

1.92

0.00021

KW-0539

Nucleus

5 of 285

1.23

1.09

0.00069

KW-0963

Cytoplasm

3 of 137

1.32

0.71

0.0262

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01926

50S ribosome-binding GTPase

3 of 19

2.18

1.55

0.0011

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR006073

GTP binding domain

3 of 13

2.35

1.58

0.0011

IPR030378

Circularly permuted (CP)-type guanine nucleotide-binding (G) domain

2 of 4

2.68

0.96

0.0179

IPR022755

Zinc finger, double-stranded RNA binding

2 of 7

2.44

0.85

0.0286

IPR003604

Matrin/U1-C-like, C2H2-type zinc finger

2 of 8

2.38

0.84

0.0286

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