node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
FEN1 | KFL_000070060 | A0A1Y1HUF1 | A0A1Y1HHV0 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | DNA recombinational repair protein BRCA2. | 0.683 |
FEN1 | KFL_000190370 | A0A1Y1HUF1 | A0A1Y1HNR5 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | RECA_2 domain-containing protein. | 0.739 |
FEN1 | KFL_000570150 | A0A1Y1HUF1 | A0A0U9HQG7 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Replication protein A subunit; Component of the replication protein A complex (RPA) required for DNA recombination, repair and replication. The activity of RPA is mediated by single-stranded DNA binding and protein interactions. Probably involved in repair of double-strand DNA breaks (DSBs) induced by genotoxic stresses. | 0.735 |
FEN1 | KFL_000760030 | A0A1Y1HUF1 | A0A1Y1HRL4 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | DNA-repair protein XRCC3. | 0.765 |
FEN1 | KFL_001210170 | A0A1Y1HUF1 | A0A1Y1HVS1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. | 0.931 |
FEN1 | KFL_002790130 | A0A1Y1HUF1 | A0A1Y1I5N7 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Putative endonuclease containing ERCC4 domain. | 0.822 |
FEN1 | KFL_003580070 | A0A1Y1HUF1 | A0A1Y1I963 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Putative DNA repair and recombination protein RecA; Belongs to the RecA family. | 0.805 |
FEN1 | KFL_003810040 | A0A1Y1HUF1 | A0A1Y1IA94 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Helicase conserved C-terminal domain containing protein. | 0.998 |
FEN1 | KFL_004930080 | A0A1Y1HUF1 | A0A1Y1IE19 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Putative DNA repair and recombination protein RecA; Belongs to the RecA family. | 0.702 |
FEN1 | KFL_005150110 | A0A1Y1HUF1 | A0A1Y1IMM9 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | DNA recombination and repair protein. | 0.593 |
KFL_000070060 | FEN1 | A0A1Y1HHV0 | A0A1Y1HUF1 | DNA recombinational repair protein BRCA2. | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | 0.683 |
KFL_000070060 | KFL_000190370 | A0A1Y1HHV0 | A0A1Y1HNR5 | DNA recombinational repair protein BRCA2. | RECA_2 domain-containing protein. | 0.975 |
KFL_000070060 | KFL_000570150 | A0A1Y1HHV0 | A0A0U9HQG7 | DNA recombinational repair protein BRCA2. | Replication protein A subunit; Component of the replication protein A complex (RPA) required for DNA recombination, repair and replication. The activity of RPA is mediated by single-stranded DNA binding and protein interactions. Probably involved in repair of double-strand DNA breaks (DSBs) induced by genotoxic stresses. | 0.671 |
KFL_000070060 | KFL_000760030 | A0A1Y1HHV0 | A0A1Y1HRL4 | DNA recombinational repair protein BRCA2. | DNA-repair protein XRCC3. | 0.944 |
KFL_000070060 | KFL_001210170 | A0A1Y1HHV0 | A0A1Y1HVS1 | DNA recombinational repair protein BRCA2. | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. | 0.811 |
KFL_000070060 | KFL_002790130 | A0A1Y1HHV0 | A0A1Y1I5N7 | DNA recombinational repair protein BRCA2. | Putative endonuclease containing ERCC4 domain. | 0.793 |
KFL_000070060 | KFL_003580070 | A0A1Y1HHV0 | A0A1Y1I963 | DNA recombinational repair protein BRCA2. | Putative DNA repair and recombination protein RecA; Belongs to the RecA family. | 0.862 |
KFL_000070060 | KFL_003810040 | A0A1Y1HHV0 | A0A1Y1IA94 | DNA recombinational repair protein BRCA2. | Helicase conserved C-terminal domain containing protein. | 0.992 |
KFL_000070060 | KFL_004930080 | A0A1Y1HHV0 | A0A1Y1IE19 | DNA recombinational repair protein BRCA2. | Putative DNA repair and recombination protein RecA; Belongs to the RecA family. | 0.862 |
KFL_000070060 | KFL_005150110 | A0A1Y1HHV0 | A0A1Y1IMM9 | DNA recombinational repair protein BRCA2. | DNA recombination and repair protein. | 0.833 |