node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
KFL_000020720 | KFL_000430150 | A0A1Y1HL60 | A0A1Y1HPI3 | Ubiquitin-conjugating enzyme; Belongs to the ubiquitin-conjugating enzyme family. | Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family. | 0.630 |
KFL_000020720 | KFL_000610370 | A0A1Y1HL60 | A0A0U9HRA6 | Ubiquitin-conjugating enzyme; Belongs to the ubiquitin-conjugating enzyme family. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] | 0.591 |
KFL_000020720 | KFL_001040040 | A0A1Y1HL60 | A0A1Y1HZ41 | Ubiquitin-conjugating enzyme; Belongs to the ubiquitin-conjugating enzyme family. | Ubiquitin-like protein. | 0.674 |
KFL_000020720 | KFL_001700260 | A0A1Y1HL60 | A0A1Y1I469 | Ubiquitin-conjugating enzyme; Belongs to the ubiquitin-conjugating enzyme family. | E3 SUMO-protein ligase PIAS1. | 0.697 |
KFL_000020720 | KFL_001940180 | A0A1Y1HL60 | A0A1Y1I5Y1 | Ubiquitin-conjugating enzyme; Belongs to the ubiquitin-conjugating enzyme family. | DNA topoisomerase type II. | 0.675 |
KFL_000020720 | KFL_002440090 | A0A1Y1HL60 | A0A1Y1I530 | Ubiquitin-conjugating enzyme; Belongs to the ubiquitin-conjugating enzyme family. | Small ubiquitin-related modifier. | 0.674 |
KFL_000020720 | KFL_003580190 | A0A1Y1HL60 | A0A1Y1IFJ0 | Ubiquitin-conjugating enzyme; Belongs to the ubiquitin-conjugating enzyme family. | Rad60-SLD domain-containing protein. | 0.674 |
KFL_000020720 | KFL_003830120 | A0A1Y1HL60 | A0A1Y1IBC2 | Ubiquitin-conjugating enzyme; Belongs to the ubiquitin-conjugating enzyme family. | Uncharacterized protein. | 0.674 |
KFL_000020720 | KFL_005290050 | A0A1Y1HL60 | A0A1Y1IF08 | Ubiquitin-conjugating enzyme; Belongs to the ubiquitin-conjugating enzyme family. | Uncharacterized protein. | 0.697 |
KFL_000020720 | KFL_005640010 | A0A1Y1HL60 | A0A1Y1IG19 | Ubiquitin-conjugating enzyme; Belongs to the ubiquitin-conjugating enzyme family. | DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner. | 0.675 |
KFL_000430150 | KFL_000020720 | A0A1Y1HPI3 | A0A1Y1HL60 | Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family. | Ubiquitin-conjugating enzyme; Belongs to the ubiquitin-conjugating enzyme family. | 0.630 |
KFL_000430150 | KFL_000610370 | A0A1Y1HPI3 | A0A0U9HRA6 | Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] | 0.607 |
KFL_000430150 | KFL_001040040 | A0A1Y1HPI3 | A0A1Y1HZ41 | Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family. | Ubiquitin-like protein. | 0.581 |
KFL_000430150 | KFL_001940180 | A0A1Y1HPI3 | A0A1Y1I5Y1 | Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family. | DNA topoisomerase type II. | 0.766 |
KFL_000430150 | KFL_002440090 | A0A1Y1HPI3 | A0A1Y1I530 | Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family. | Small ubiquitin-related modifier. | 0.581 |
KFL_000430150 | KFL_003580190 | A0A1Y1HPI3 | A0A1Y1IFJ0 | Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family. | Rad60-SLD domain-containing protein. | 0.565 |
KFL_000430150 | KFL_003830120 | A0A1Y1HPI3 | A0A1Y1IBC2 | Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family. | Uncharacterized protein. | 0.581 |
KFL_000430150 | KFL_005640010 | A0A1Y1HPI3 | A0A1Y1IG19 | Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family. | DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner. | 0.766 |
KFL_000610370 | KFL_000020720 | A0A0U9HRA6 | A0A1Y1HL60 | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] | Ubiquitin-conjugating enzyme; Belongs to the ubiquitin-conjugating enzyme family. | 0.591 |
KFL_000610370 | KFL_000430150 | A0A0U9HRA6 | A0A1Y1HPI3 | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] | Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family. | 0.607 |