node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
FEN1 | KFL_000130430 | A0A1Y1HUF1 | A0A1Y1HN98 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Putative DNA repair protein XPGC. | 0.643 |
FEN1 | KFL_000450090 | A0A1Y1HUF1 | A0A1Y1HPQ6 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | DNA repair protein XPGC. | 0.643 |
FEN1 | KFL_001210170 | A0A1Y1HUF1 | A0A1Y1HVS1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. | 0.931 |
FEN1 | KFL_003400150 | A0A1Y1HUF1 | A0A1Y1IBA5 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | DNA polymerase I. | 0.658 |
FEN1 | KFL_006730030 | A0A1Y1HUF1 | A0A1Y1IKL5 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | DNA repair protein RAD50. | 0.884 |
FEN1 | KFL_006980030 | A0A1Y1HUF1 | A0A1Y1IJ60 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | DNA ligase. | 0.979 |
FEN1 | KFL_007100020 | A0A1Y1HUF1 | A0A1Y1IJC3 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | DNA polymerase I superfamily. | 0.658 |
KFL_000130430 | FEN1 | A0A1Y1HN98 | A0A1Y1HUF1 | Putative DNA repair protein XPGC. | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | 0.643 |
KFL_000130430 | KFL_000450090 | A0A1Y1HN98 | A0A1Y1HPQ6 | Putative DNA repair protein XPGC. | DNA repair protein XPGC. | 0.877 |
KFL_000130430 | KFL_000610170 | A0A1Y1HN98 | A0A0U9HKJ8 | Putative DNA repair protein XPGC. | Putative DNA repair protein XPGC. | 0.643 |
KFL_000130430 | KFL_001210170 | A0A1Y1HN98 | A0A1Y1HVS1 | Putative DNA repair protein XPGC. | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. | 0.976 |
KFL_000130430 | KFL_003400150 | A0A1Y1HN98 | A0A1Y1IBA5 | Putative DNA repair protein XPGC. | DNA polymerase I. | 0.700 |
KFL_000130430 | KFL_006730030 | A0A1Y1HN98 | A0A1Y1IKL5 | Putative DNA repair protein XPGC. | DNA repair protein RAD50. | 0.889 |
KFL_000130430 | KFL_006980030 | A0A1Y1HN98 | A0A1Y1IJ60 | Putative DNA repair protein XPGC. | DNA ligase. | 0.954 |
KFL_000130430 | KFL_007100020 | A0A1Y1HN98 | A0A1Y1IJC3 | Putative DNA repair protein XPGC. | DNA polymerase I superfamily. | 0.700 |
KFL_000130430 | KFL_009620020 | A0A1Y1HN98 | A0A1Y1ISM1 | Putative DNA repair protein XPGC. | DNA repair protein XPGC. | 0.643 |
KFL_000400420 | KFL_003400150 | A0A1Y1HVN0 | A0A1Y1IBA5 | Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. | DNA polymerase I. | 0.664 |
KFL_000400420 | KFL_006980030 | A0A1Y1HVN0 | A0A1Y1IJ60 | Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. | DNA ligase. | 0.699 |
KFL_000400420 | KFL_007100020 | A0A1Y1HVN0 | A0A1Y1IJC3 | Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. | DNA polymerase I superfamily. | 0.664 |
KFL_000450090 | FEN1 | A0A1Y1HPQ6 | A0A1Y1HUF1 | DNA repair protein XPGC. | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | 0.643 |