AAWM_00168 protein (Aspergillus awamori) - STRING interaction network

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second shell of interactors

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Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

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Score

AAWM_00168

PNP_UDP_1 domain-containing protein. (1454 aa)

Predicted Functional Partners:

AAWM_06038

0.745

AAWM_01617

0.731

AAWM_01099

0.730

AAWM_01298

0.727

AAWM_08904

0.727

AAWM_08910

0.727

AAWM_05238

0.726

AAWM_03833

0.725

AAWM_03424

0.713

AAWM_00750

0.665

Your Current Organism:

Aspergillus awamori

NCBI taxonomy Id: 105351
Other names: A. awamori, ATCC 16877, Aspergillus awamorii, Aspergillus niger var. awamori, Aspergillus niger var. awamorii, CBS 557.65, ITEM 4509

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AAWM_00168	AAWM_00750	A0A401KD91	A0A401KFA2	PNP_UDP_1 domain-containing protein.	FACT complex subunit spt16.	0.665
AAWM_00168	AAWM_01099	A0A401KD91	A0A401KFU2	PNP_UDP_1 domain-containing protein.	Anaphase-promoting complex subunit cut9.	0.730
AAWM_00168	AAWM_01298	A0A401KD91	A0A401KGF9	PNP_UDP_1 domain-containing protein.	Uncharacterized protein.	0.727
AAWM_00168	AAWM_01617	A0A401KD91	A0A401KHT5	PNP_UDP_1 domain-containing protein.	Cell division control protein 73.	0.731
AAWM_00168	AAWM_03424	A0A401KD91	A0A401KMQ0	PNP_UDP_1 domain-containing protein.	Anaphase-promoting complex subunit 2; Belongs to the cullin family.	0.713
AAWM_00168	AAWM_03833	A0A401KD91	A0A401KNS4	PNP_UDP_1 domain-containing protein.	Negative regulator of mitosis.	0.725
AAWM_00168	AAWM_05238	A0A401KD91	A0A401KST5	PNP_UDP_1 domain-containing protein.	RNA polymerase-associated protein LEO1.	0.726
AAWM_00168	AAWM_06038	A0A401KD91	A0A401KV07	PNP_UDP_1 domain-containing protein.	Kinesin heavy chain; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.745
AAWM_00168	AAWM_08904	A0A401KD91	A0A401L3D0	PNP_UDP_1 domain-containing protein.	Anaphase-promoting complex subunit 10.	0.727
AAWM_00168	AAWM_08910	A0A401KD91	A0A401L3D7	PNP_UDP_1 domain-containing protein.	Anaphase-promoting complex subunit 4.	0.727
AAWM_00750	AAWM_00168	A0A401KFA2	A0A401KD91	FACT complex subunit spt16.	PNP_UDP_1 domain-containing protein.	0.665
AAWM_00750	AAWM_01298	A0A401KFA2	A0A401KGF9	FACT complex subunit spt16.	Uncharacterized protein.	0.974
AAWM_00750	AAWM_01617	A0A401KFA2	A0A401KHT5	FACT complex subunit spt16.	Cell division control protein 73.	0.995
AAWM_00750	AAWM_05238	A0A401KFA2	A0A401KST5	FACT complex subunit spt16.	RNA polymerase-associated protein LEO1.	0.987
AAWM_01099	AAWM_00168	A0A401KFU2	A0A401KD91	Anaphase-promoting complex subunit cut9.	PNP_UDP_1 domain-containing protein.	0.730
AAWM_01099	AAWM_03424	A0A401KFU2	A0A401KMQ0	Anaphase-promoting complex subunit cut9.	Anaphase-promoting complex subunit 2; Belongs to the cullin family.	0.998
AAWM_01099	AAWM_03833	A0A401KFU2	A0A401KNS4	Anaphase-promoting complex subunit cut9.	Negative regulator of mitosis.	0.998
AAWM_01099	AAWM_08904	A0A401KFU2	A0A401L3D0	Anaphase-promoting complex subunit cut9.	Anaphase-promoting complex subunit 10.	0.998
AAWM_01099	AAWM_08910	A0A401KFU2	A0A401L3D7	Anaphase-promoting complex subunit cut9.	Anaphase-promoting complex subunit 4.	0.998
AAWM_01298	AAWM_00168	A0A401KGF9	A0A401KD91	Uncharacterized protein.	PNP_UDP_1 domain-containing protein.	0.727

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Network Stats

number of nodes:

11

number of edges:

18

average node degree:

3.27

avg. local clustering coefficient:

0.695

expected number of edges:

15

PPI enrichment p-value:

0.234

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0051028

mRNA transport

10 of 79

2.7

10.92

3.66e-23

GO:0006406

mRNA export from nucleus

9 of 56

2.8

10.61

8.32e-22

GO:0006397

mRNA processing

6 of 414

1.76

2.83

6.86e-08

GO:0010467

Gene expression

11 of 1776

1.39

2.62

1.99e-13

GO:0016973

poly(A)+ mRNA export from nucleus

2 of 22

2.56

1.44

0.0023

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003723

RNA binding

11 of 1120

1.59

3.6

6.56e-15

GO:0003729

mRNA binding

5 of 205

1.98

2.92

4.19e-07

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000445

THO complex part of transcription export complex

5 of 8

3.39

6.81

4.04e-13

GO:0016607

Nuclear speck

5 of 143

2.14

3.57

2.85e-08

GO:0140513

Nuclear protein-containing complex

8 of 1136

1.44

2.32

7.61e-09

GO:0005681

Spliceosomal complex

3 of 278

1.63

1.22

0.0023

GO:0005634

Nucleus

11 of 5174

0.92

1.08

1.22e-08

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:8411

mRNA export from nucleus, and THO complex subunit 2

9 of 30

3.07

12.05

1.08e-23

CL:8409

mRNA transport, and Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

10 of 66

2.78

11.61

3.37e-24

CL:8419

THO complex, and poly(A)+ mRNA export from nucleus

8 of 19

3.22

11.26

9.85e-22

CL:8408

Mixed, incl. RNA Polymerase II Transcription Termination, and Regulation of RNA splicing

11 of 116

2.57

11.24

3.62e-25

CL:8423

THO complex

5 of 10

3.3

6.67

6.50e-13

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

aqu03040

Spliceosome

6 of 109

2.34

5.17

1.68e-11

aqu03013

RNA transport

6 of 125

2.28

5.05

1.86e-11

aqu03015

mRNA surveillance pathway

2 of 66

2.08

1.19

0.0054

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-73856

RNA Polymerase II Transcription Termination

11 of 97

2.65

12.14

1.31e-26

MAP-159236

Transport of Mature mRNA derived from an Intron-Containing Transcript

11 of 100

2.64

12.08

1.31e-26

MAP-72202

Transport of Mature Transcript to Cytoplasm

11 of 111

2.59

11.82

1.77e-26

MAP-72203

Processing of Capped Intron-Containing Pre-mRNA

11 of 476

1.96

6.32

7.74e-20

MAP-8953854

Metabolism of RNA

11 of 1040

1.62

3.9

3.11e-16

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0000347

THO complex

5 of 10

3.3

6.52

1.20e-12

GOCC:0000346

Transcription export complex

5 of 11

3.25

6.51

1.20e-12

GOCC:0000445

THO complex part of transcription export complex

3 of 6

3.3

3.71

1.88e-07

GOCC:0016607

Nuclear speck

3 of 29

2.61

2.75

7.38e-06

GOCC:0005634

Nucleus

11 of 2291

1.28

2.15

3.35e-12

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0694

RNA-binding

4 of 246

1.81

1.88

8.76e-05

KW-0508

mRNA splicing

2 of 22

2.56

1.46

0.0021

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF16134

THO complex subunit 2 N-terminus

2 of 2

3.6

1.79

0.00060

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR032302

THO complex subunit 2, N-terminal domain

2 of 2

3.6

1.89

0.00040

IPR000504

RNA recognition motif domain

4 of 158

2.0

1.78

0.00028

IPR035979

RNA-binding domain superfamily

4 of 177

1.95

1.75

0.00028

IPR012677

Nucleotide-binding alpha-beta plait domain superfamily

4 of 186

1.93

1.74

0.00028

IPR040007

THO complex subunit 2

2 of 6

3.12

1.57

0.0015

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00360

RNA recognition motif

4 of 151

2.02

2.23

2.68e-05

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