AAWM_00765 protein (Aspergillus awamori) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

AAWM_00765

DNA polymerase epsilon subunit B. (748 aa)

Predicted Functional Partners:

AAWM_08090

0.999

AAWM_02614

0.994

AAWM_05384

0.994

AAWM_08964

0.994

AAWM_01093

0.992

AAWM_11100

0.992

AAWM_09755

0.991

AAWM_02137

0.990

AAWM_00712

0.984

AAWM_01659

0.982

Your Current Organism:

Aspergillus awamori

NCBI taxonomy Id: 105351
Other names: A. awamori, ATCC 16877, Aspergillus awamorii, Aspergillus niger var. awamori, Aspergillus niger var. awamorii, CBS 557.65, ITEM 4509

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AAWM_00712	AAWM_00765	A0A401KEX7	A0A401KEY0	Minichromosome loss protein 1.	DNA polymerase epsilon subunit B.	0.984
AAWM_00712	AAWM_01093	A0A401KEX7	A0A401KFZ7	Minichromosome loss protein 1.	DNA helicase; Belongs to the MCM family.	0.992
AAWM_00712	AAWM_01659	A0A401KEX7	A0A401KHD0	Minichromosome loss protein 1.	DNA polymerase.	0.996
AAWM_00712	AAWM_02137	A0A401KEX7	A0A401KJ94	Minichromosome loss protein 1.	DNA helicase; Belongs to the MCM family.	0.990
AAWM_00712	AAWM_02614	A0A401KEX7	A0A401KKL0	Minichromosome loss protein 1.	DNA helicase; Belongs to the MCM family.	0.990
AAWM_00712	AAWM_08090	A0A401KEX7	A0A401L0U3	Minichromosome loss protein 1.	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.	0.980
AAWM_00712	AAWM_08964	A0A401KEX7	A0A401L3I9	Minichromosome loss protein 1.	Cell division control protein 45 homolog.	0.992
AAWM_00712	AAWM_09755	A0A401KEX7	A0A401L5W0	Minichromosome loss protein 1.	DNA helicase; Belongs to the MCM family.	0.992
AAWM_00712	AAWM_11100	A0A401KEX7	A0A401L9T1	Minichromosome loss protein 1.	DNA helicase; Belongs to the MCM family.	0.995
AAWM_00765	AAWM_00712	A0A401KEY0	A0A401KEX7	DNA polymerase epsilon subunit B.	Minichromosome loss protein 1.	0.984
AAWM_00765	AAWM_01093	A0A401KEY0	A0A401KFZ7	DNA polymerase epsilon subunit B.	DNA helicase; Belongs to the MCM family.	0.992
AAWM_00765	AAWM_01659	A0A401KEY0	A0A401KHD0	DNA polymerase epsilon subunit B.	DNA polymerase.	0.982
AAWM_00765	AAWM_02137	A0A401KEY0	A0A401KJ94	DNA polymerase epsilon subunit B.	DNA helicase; Belongs to the MCM family.	0.990
AAWM_00765	AAWM_02614	A0A401KEY0	A0A401KKL0	DNA polymerase epsilon subunit B.	DNA helicase; Belongs to the MCM family.	0.994
AAWM_00765	AAWM_05384	A0A401KEY0	A0A401KTD9	DNA polymerase epsilon subunit B.	DNA polymerase epsilon subunit D.	0.994
AAWM_00765	AAWM_08090	A0A401KEY0	A0A401L0U3	DNA polymerase epsilon subunit B.	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.	0.999
AAWM_00765	AAWM_08964	A0A401KEY0	A0A401L3I9	DNA polymerase epsilon subunit B.	Cell division control protein 45 homolog.	0.994
AAWM_00765	AAWM_09755	A0A401KEY0	A0A401L5W0	DNA polymerase epsilon subunit B.	DNA helicase; Belongs to the MCM family.	0.991
AAWM_00765	AAWM_11100	A0A401KEY0	A0A401L9T1	DNA polymerase epsilon subunit B.	DNA helicase; Belongs to the MCM family.	0.992
AAWM_01093	AAWM_00712	A0A401KFZ7	A0A401KEX7	DNA helicase; Belongs to the MCM family.	Minichromosome loss protein 1.	0.992

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

38

average node degree:

6.91

avg. local clustering coefficient:

0.897

expected number of edges:

21

PPI enrichment p-value:

0.000633

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000413

Protein peptidyl-prolyl isomerization

3 of 3

2.71

2.05

0.00017

GO:0006457

Protein folding

3 of 26

1.77

1.23

0.0030

GO:0006412

Translation

5 of 125

1.31

1.16

0.00077

GO:0019538

Protein metabolic process

8 of 414

0.99

0.93

0.00017

GO:0009059

Macromolecule biosynthetic process

6 of 288

1.02

0.84

0.0016

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003755

Peptidyl-prolyl cis-trans isomerase activity

3 of 8

2.28

1.64

0.00080

GO:0019843

rRNA binding

4 of 42

1.68

1.43

0.00080

GO:0003735

Structural constituent of ribosome

4 of 57

1.55

1.33

0.00086

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005840

Ribosome

4 of 63

1.51

1.4

0.00044

GO:0043226

Organelle

6 of 234

1.11

1.03

0.00034

GO:0043229

Intracellular organelle

5 of 185

1.14

0.99

0.00085

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:773

Mixed, incl. Protein peptidyl-prolyl isomerization, and DEAD-like helicases superfamily

6 of 15

2.31

4.44

7.51e-10

CL:180

Ribosome

4 of 31

1.82

1.91

7.53e-05

CL:166

Ribosome, and Translational elongation

5 of 73

1.54

1.7

5.15e-05

CL:182

rRNA-binding

3 of 24

1.8

1.45

0.00098

CL:775

DEAD-like helicases superfamily, and UmuC domain

2 of 5

2.31

1.27

0.0043

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

lagg03010

Ribosome

4 of 55

1.57

1.45

0.00042

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005840

Ribosome

4 of 48

1.63

1.42

0.00068

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0697

Rotamase

3 of 7

2.34

2.02

0.00015

KW-0699

rRNA-binding

4 of 39

1.72

0.00015

KW-0689

Ribosomal protein

4 of 58

1.54

1.46

0.00033

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00160

Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD

2 of 2

2.71

0.99

0.0159

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR044666

Cyclophilin-type peptidyl-prolyl cis-trans isomerase, cyclophilin A-like

2 of 2

2.71

0.78

0.0384

IPR029000

Cyclophilin-like domain superfamily

2 of 3

2.53

0.78

0.0384

IPR002130

Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain

2 of 2

2.71

0.78

0.0384

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