AAWM_04043 protein (Aspergillus awamori) - STRING interaction network

Nodes:

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second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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Score

AAWM_04043

Uncharacterized transcriptional regulatory protein C530.05. (594 aa)

Predicted Functional Partners:

AAWM_00261

0.563

AAWM_05597

0.522

AAWM_04925

0.508

AAWM_10583

0.508

AAWM_06443

0.507

AAWM_07645

0.498

AAWM_07137

0.496

AAWM_02957

0.495

AAWM_00437

0.493

AAWM_01243

0.493

Your Current Organism:

Aspergillus awamori

NCBI taxonomy Id: 105351
Other names: A. awamori, ATCC 16877, Aspergillus awamorii, Aspergillus niger var. awamori, Aspergillus niger var. awamorii, CBS 557.65, ITEM 4509

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AAWM_00261	AAWM_02957	A0A401KDS7	A0A401KLP1	UBA domain-containing protein 7.	Putative ankyrin repeat protein RF_0381.	0.810
AAWM_00261	AAWM_04043	A0A401KDS7	A0A401KPE4	UBA domain-containing protein 7.	Uncharacterized transcriptional regulatory protein C530.05.	0.563
AAWM_00261	AAWM_04925	A0A401KDS7	A0A401KRY1	UBA domain-containing protein 7.	Glycerophosphodiester phosphodiesterase GDE1.	0.475
AAWM_00261	AAWM_06443	A0A401KDS7	A0A401KW74	UBA domain-containing protein 7.	Polyubiquitin.	0.938
AAWM_00261	AAWM_07137	A0A401KDS7	A0A401KYE1	UBA domain-containing protein 7.	AP-2 complex subunit mu; Belongs to the adaptor complexes medium subunit family.	0.495
AAWM_00261	AAWM_10583	A0A401KDS7	A0A401L874	UBA domain-containing protein 7.	Glycerophosphodiester phosphodiesterase GDE1.	0.475
AAWM_00437	AAWM_01243	A0A401KEA0	A0A401KGC8	Uncharacterized protein YKR070W.	Uncharacterized CDP-alcohol phosphatidyltransferase class-I family protein C22A12.08c.	0.761
AAWM_00437	AAWM_02957	A0A401KEA0	A0A401KLP1	Uncharacterized protein YKR070W.	Putative ankyrin repeat protein RF_0381.	0.656
AAWM_00437	AAWM_04043	A0A401KEA0	A0A401KPE4	Uncharacterized protein YKR070W.	Uncharacterized transcriptional regulatory protein C530.05.	0.493
AAWM_00437	AAWM_04925	A0A401KEA0	A0A401KRY1	Uncharacterized protein YKR070W.	Glycerophosphodiester phosphodiesterase GDE1.	0.926
AAWM_00437	AAWM_10583	A0A401KEA0	A0A401L874	Uncharacterized protein YKR070W.	Glycerophosphodiester phosphodiesterase GDE1.	0.926
AAWM_01243	AAWM_00437	A0A401KGC8	A0A401KEA0	Uncharacterized CDP-alcohol phosphatidyltransferase class-I family protein C22A12.08c.	Uncharacterized protein YKR070W.	0.761
AAWM_01243	AAWM_02957	A0A401KGC8	A0A401KLP1	Uncharacterized CDP-alcohol phosphatidyltransferase class-I family protein C22A12.08c.	Putative ankyrin repeat protein RF_0381.	0.656
AAWM_01243	AAWM_04043	A0A401KGC8	A0A401KPE4	Uncharacterized CDP-alcohol phosphatidyltransferase class-I family protein C22A12.08c.	Uncharacterized transcriptional regulatory protein C530.05.	0.493
AAWM_01243	AAWM_04925	A0A401KGC8	A0A401KRY1	Uncharacterized CDP-alcohol phosphatidyltransferase class-I family protein C22A12.08c.	Glycerophosphodiester phosphodiesterase GDE1.	0.926
AAWM_01243	AAWM_10583	A0A401KGC8	A0A401L874	Uncharacterized CDP-alcohol phosphatidyltransferase class-I family protein C22A12.08c.	Glycerophosphodiester phosphodiesterase GDE1.	0.926
AAWM_02957	AAWM_00261	A0A401KLP1	A0A401KDS7	Putative ankyrin repeat protein RF_0381.	UBA domain-containing protein 7.	0.810
AAWM_02957	AAWM_00437	A0A401KLP1	A0A401KEA0	Putative ankyrin repeat protein RF_0381.	Uncharacterized protein YKR070W.	0.656
AAWM_02957	AAWM_01243	A0A401KLP1	A0A401KGC8	Putative ankyrin repeat protein RF_0381.	Uncharacterized CDP-alcohol phosphatidyltransferase class-I family protein C22A12.08c.	0.656
AAWM_02957	AAWM_04043	A0A401KLP1	A0A401KPE4	Putative ankyrin repeat protein RF_0381.	Uncharacterized transcriptional regulatory protein C530.05.	0.495

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Network Stats

number of nodes:

2

number of edges:

1

average node degree:

1

avg. local clustering coefficient:

1

expected number of edges:

1

PPI enrichment p-value:

0.5

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006388

tRNA splicing, via endonucleolytic cleavage and ligation

5 of 9

2.78

4.67

1.71e-09

GO:0000379

tRNA-type intron splice site recognition and cleavage

4 of 5

2.94

3.92

6.09e-08

GO:0008033

tRNA processing

6 of 117

1.74

2.66

2.21e-07

GO:0034470

ncRNA processing

7 of 326

1.36

1.8

1.07e-06

GO:0006396

RNA processing

8 of 560

1.19

1.47

1.07e-06

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000213

tRNA-intron endonuclease activity

3 of 4

2.91

2.45

3.34e-05

GO:0004521

Endoribonuclease activity

4 of 44

1.99

2.17

3.34e-05

GO:0140101

Catalytic activity, acting on a tRNA

4 of 95

1.66

1.57

0.00029

GO:0140098

Catalytic activity, acting on RNA

5 of 251

1.33

1.27

0.00034

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000214

tRNA-intron endonuclease complex

4 of 5

2.94

4.0

4.25e-08

GO:0140513

Nuclear protein-containing complex

9 of 659

1.17

1.52

1.14e-07

GO:0005849

mRNA cleavage factor complex

2 of 15

2.16

1.11

0.0081

GO:1902494

Catalytic complex

6 of 648

1.0

0.82

0.0014

GO:0005634

Nucleus

10 of 2393

0.65

0.56

0.00022

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:17980

RNA splicing, via endonucleolytic cleavage and ligation

3 of 6

2.73

2.2

9.21e-05

CL:2899

Processing of Intronless Pre-mRNAs

2 of 6

2.55

1.03

0.0135

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03015

mRNA surveillance pathway

3 of 101

1.5

0.85

0.0154

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-77595

Processing of Intronless Pre-mRNAs

3 of 16

2.31

1.88

0.00027

MAP-75067

Processing of Capped Intronless Pre-mRNA

3 of 24

2.13

1.69

0.00055

MAP-73856

RNA Polymerase II Transcription Termination

3 of 40

1.91

1.43

0.0014

MAP-8953854

Metabolism of RNA

7 of 580

1.11

1.07

0.00019

MAP-74160

Gene expression (Transcription)

6 of 591

1.04

0.86

0.0014

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0000214

tRNA-intron endonuclease complex

4 of 6

2.86

3.82

8.44e-08

GOCC:0005634

Nucleus

9 of 1402

0.84

0.79

5.17e-05

GOCC:1902494

Catalytic complex

6 of 838

0.89

0.64

0.0054

GOCC:0032991

Protein-containing complex

9 of 2362

0.61

0.47

0.0031

GOCC:0043231

Intracellular membrane-bounded organelle

10 of 3101

0.54

0.42

0.0026

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0819

tRNA processing

2 of 19

2.05

0.75

0.0397

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01974

tRNA intron endonuclease, catalytic C-terminal domain

2 of 2

3.03

1.28

0.0050

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036167

tRNA intron endonuclease, catalytic domain-like superfamily

3 of 3

3.03

2.45

3.54e-05

IPR011856

tRNA endonuclease-like domain superfamily

3 of 4

2.91

2.44

3.54e-05

IPR006677

tRNA intron endonuclease, catalytic domain-like

2 of 2

3.03

1.29

0.0047

IPR006676

tRNA-splicing endonuclease

2 of 2

3.03

1.29

0.0047

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