AAWM_04196 protein (Aspergillus awamori) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

AAWM_04196

Dicarboxylic amino acid permease. (549 aa)

Predicted Functional Partners:

AAWM_05636

0.520

AAWM_05755

0.490

AAWM_06618

0.490

AAWM_02540

0.484

AAWM_01331

0.433

AAWM_02337

0.433

AAWM_00551

0.405

AAWM_00887

0.405

AAWM_01609

0.405

AAWM_02012

0.405

Your Current Organism:

Aspergillus awamori

NCBI taxonomy Id: 105351
Other names: A. awamori, ATCC 16877, Aspergillus awamorii, Aspergillus niger var. awamori, Aspergillus niger var. awamorii, CBS 557.65, ITEM 4509

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AAWM_00551	AAWM_00887	A0A401KEN7	A0A401KFM2	Uncharacterized protein.	Alpha-glucosidase.	0.698
AAWM_00551	AAWM_02012	A0A401KEN7	A0A401KIL2	Uncharacterized protein.	DNA oxidative demethylase ALKBH2.	0.698
AAWM_00551	AAWM_04196	A0A401KEN7	A0A401KPX4	Uncharacterized protein.	Dicarboxylic amino acid permease.	0.405
AAWM_00551	AAWM_05755	A0A401KEN7	A0A401KUA2	Uncharacterized protein.	High-affinity methionine permease.	0.497
AAWM_00551	AAWM_06618	A0A401KEN7	A0A401KWQ4	Uncharacterized protein.	High-affinity methionine permease.	0.497
AAWM_00887	AAWM_00551	A0A401KFM2	A0A401KEN7	Alpha-glucosidase.	Uncharacterized protein.	0.698
AAWM_00887	AAWM_04196	A0A401KFM2	A0A401KPX4	Alpha-glucosidase.	Dicarboxylic amino acid permease.	0.405
AAWM_00887	AAWM_05755	A0A401KFM2	A0A401KUA2	Alpha-glucosidase.	High-affinity methionine permease.	0.693
AAWM_00887	AAWM_06618	A0A401KFM2	A0A401KWQ4	Alpha-glucosidase.	High-affinity methionine permease.	0.693
AAWM_01331	AAWM_04196	A0A401KGV9	A0A401KPX4	Arginase; Belongs to the arginase family.	Dicarboxylic amino acid permease.	0.433
AAWM_01609	AAWM_04196	A0A401KH77	A0A401KPX4	Cell wall alpha-1,3-glucan synthase ags1.	Dicarboxylic amino acid permease.	0.405
AAWM_01609	AAWM_05755	A0A401KH77	A0A401KUA2	Cell wall alpha-1,3-glucan synthase ags1.	High-affinity methionine permease.	0.497
AAWM_01609	AAWM_06618	A0A401KH77	A0A401KWQ4	Cell wall alpha-1,3-glucan synthase ags1.	High-affinity methionine permease.	0.497
AAWM_02012	AAWM_00551	A0A401KIL2	A0A401KEN7	DNA oxidative demethylase ALKBH2.	Uncharacterized protein.	0.698
AAWM_02012	AAWM_04196	A0A401KIL2	A0A401KPX4	DNA oxidative demethylase ALKBH2.	Dicarboxylic amino acid permease.	0.405
AAWM_02012	AAWM_05755	A0A401KIL2	A0A401KUA2	DNA oxidative demethylase ALKBH2.	High-affinity methionine permease.	0.693
AAWM_02012	AAWM_06618	A0A401KIL2	A0A401KWQ4	DNA oxidative demethylase ALKBH2.	High-affinity methionine permease.	0.693
AAWM_02337	AAWM_04196	A0A401KJY1	A0A401KPX4	Arginase; Belongs to the arginase family.	Dicarboxylic amino acid permease.	0.433
AAWM_02540	AAWM_04196	A0A401KKB6	A0A401KPX4	Peroxisomal NADH pyrophosphatase NUDT12.	Dicarboxylic amino acid permease.	0.484
AAWM_02540	AAWM_05636	A0A401KKB6	A0A401KU34	Peroxisomal NADH pyrophosphatase NUDT12.	Multifunctional tryptophan biosynthesis protein; Trifunctional enzyme bearing the Gln amidotransferase (GATase) domain of anthranilate synthase, indole-glycerolphosphate synthase, and phosphoribosylanthranilate isomerase activities.	0.410

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Network Stats

number of nodes:

6

number of edges:

13

average node degree:

4.33

avg. local clustering coefficient:

0.9

expected number of edges:

5

PPI enrichment p-value:

0.00201

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009168

Purine ribonucleoside monophosphate biosynthetic process

7 of 18

1.88

3.49

2.80e-09

GO:0006189

De novo IMP biosynthetic process

6 of 13

1.96

3.49

8.61e-09

GO:0009152

Purine ribonucleotide biosynthetic process

7 of 35

1.6

2.69

8.99e-09

GO:0009260

Ribonucleotide biosynthetic process

8 of 47

1.53

2.6

2.80e-09

GO:0044208

De novo AMP biosynthetic process

2 of 2

2.29

1.42

0.0022

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016879

Ligase activity, forming carbon-nitrogen bonds

5 of 35

1.45

1.4

0.00029

GO:0016742

Hydroxymethyl-, formyl- and related transferase activity

2 of 3

2.12

0.81

0.0319

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005829

Cytosol

5 of 98

1.0

0.75

0.0039

GO:0005622

Intracellular anatomical structure

11 of 680

0.5

0.43

0.00030

GO:0005737

Cytoplasm

9 of 557

0.5

0.38

0.0055

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:946

De novo IMP biosynthetic process

7 of 11

2.1

4.44

8.92e-11

CL:828

Cellular amino acid biosynthetic process, and Ribonucleoside monophosphate biosynthetic process

8 of 105

1.18

1.48

4.72e-07

CL:948

Phosphoribosylformylglycinamidine synthase activity, and PurE domain

2 of 6

1.82

0.78

0.0315

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00230

Purine metabolism

7 of 45

1.49

2.25

8.35e-08

map00670

One carbon pool by folate

2 of 6

1.82

0.93

0.0149

map00250

Alanine, aspartate and glutamate metabolism

3 of 25

1.37

0.84

0.0125

map01110

Biosynthesis of secondary metabolites

7 of 313

0.64

0.44

0.0125

map01100

Metabolic pathways

9 of 679

0.42

0.31

0.0160

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0658

Purine biosynthesis

5 of 11

1.95

2.81

6.58e-07

KW-0436

Ligase

5 of 56

1.25

1.16

0.00040

KW-0460

Magnesium

4 of 45

1.24

0.96

0.0030

KW-0315

Glutamine amidotransferase

2 of 12

1.52

0.64

0.0496

KW-0547

Nucleotide-binding

5 of 145

0.83

0.54

0.0162

(more ...)

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