node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AAWM_00261 | AAWM_00583 | A0A401KDS7 | A0A401KEG3 | UBA domain-containing protein 7. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. | 0.687 |
AAWM_00261 | AAWM_00788 | A0A401KDS7 | A0A401KF14 | UBA domain-containing protein 7. | GMP synthase. | 0.680 |
AAWM_00261 | AAWM_02246 | A0A401KDS7 | A0A401KJH4 | UBA domain-containing protein 7. | Golgi apyrase; Belongs to the GDA1/CD39 NTPase family. | 0.652 |
AAWM_00261 | AAWM_05206 | A0A401KDS7 | A0A401KSW3 | UBA domain-containing protein 7. | Guanylate kinase. | 0.752 |
AAWM_00261 | AAWM_05527 | A0A401KDS7 | A0A401KTN0 | UBA domain-containing protein 7. | Probable guanosine-diphosphatase; Belongs to the GDA1/CD39 NTPase family. | 0.810 |
AAWM_00261 | AAWM_07644 | A0A401KDS7 | A0A401KZD6 | UBA domain-containing protein 7. | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.680 |
AAWM_00261 | AAWM_08920 | A0A401KDS7 | A0A401L3E7 | UBA domain-containing protein 7. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | 0.696 |
AAWM_00261 | AAWM_10007 | A0A401KDS7 | A0A401L6I0 | UBA domain-containing protein 7. | Uridylate kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and dUMP as phosphate acceptors, but can also use CMP, dCMP and AMP. Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. | 0.773 |
AAWM_00261 | AAWM_10671 | A0A401KDS7 | A0A401L8E0 | UBA domain-containing protein 7. | Uncharacterized pyrophosphatase/phosphodiesterase C725.05c. | 0.679 |
AAWM_00261 | ADK2 | A0A401KDS7 | A0A401L5D0 | UBA domain-containing protein 7. | GTP:AMP phosphotransferase, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. | 0.683 |
AAWM_00583 | AAWM_00261 | A0A401KEG3 | A0A401KDS7 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. | UBA domain-containing protein 7. | 0.687 |
AAWM_00583 | AAWM_00788 | A0A401KEG3 | A0A401KF14 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. | GMP synthase. | 0.996 |
AAWM_00583 | AAWM_05206 | A0A401KEG3 | A0A401KSW3 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. | Guanylate kinase. | 0.824 |
AAWM_00583 | AAWM_05527 | A0A401KEG3 | A0A401KTN0 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. | Probable guanosine-diphosphatase; Belongs to the GDA1/CD39 NTPase family. | 0.671 |
AAWM_00583 | AAWM_07644 | A0A401KEG3 | A0A401KZD6 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.953 |
AAWM_00583 | AAWM_08920 | A0A401KEG3 | A0A401L3E7 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | 0.990 |
AAWM_00583 | AAWM_10007 | A0A401KEG3 | A0A401L6I0 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. | Uridylate kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and dUMP as phosphate acceptors, but can also use CMP, dCMP and AMP. Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. | 0.789 |
AAWM_00583 | AAWM_10671 | A0A401KEG3 | A0A401L8E0 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. | Uncharacterized pyrophosphatase/phosphodiesterase C725.05c. | 0.652 |
AAWM_00583 | ADK2 | A0A401KEG3 | A0A401L5D0 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. | GTP:AMP phosphotransferase, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. | 0.726 |
AAWM_00788 | AAWM_00261 | A0A401KF14 | A0A401KDS7 | GMP synthase. | UBA domain-containing protein 7. | 0.680 |