AAWM_05552 protein (Aspergillus awamori) - STRING interaction network

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second shell of interactors

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filled nodes:
a 3D structure is known or predicted

Edges:

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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[Homology]

Score

AAWM_05552

Proline racemase. (346 aa)

Predicted Functional Partners:

AAWM_09708

0.727

AAWM_08160

0.722

AAWM_02026

0.644

AAWM_06175

0.622

AAWM_09769

0.622

AAWM_02594

0.610

AAWM_08840

0.610

AAWM_02447

0.540

AAWM_10284

0.538

AAWM_04228

0.523

Your Current Organism:

Aspergillus awamori

NCBI taxonomy Id: 105351
Other names: A. awamori, ATCC 16877, Aspergillus awamorii, Aspergillus niger var. awamori, Aspergillus niger var. awamorii, CBS 557.65, ITEM 4509

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AAWM_02026	AAWM_04228	A0A401KIT3	A0A401KPX0	D-amino-acid oxidase.	Trans-L-3-hydroxyproline dehydratase.	0.875
AAWM_02026	AAWM_05552	A0A401KIT3	A0A401KU02	D-amino-acid oxidase.	Proline racemase.	0.644
AAWM_02026	AAWM_06175	A0A401KIT3	A0A401KVI4	D-amino-acid oxidase.	D-amino-acid oxidase.	0.828
AAWM_02026	AAWM_08160	A0A401KIT3	A0A401L121	D-amino-acid oxidase.	4-hydroxyproline 2-epimerase.	0.607
AAWM_02026	AAWM_09769	A0A401KIT3	A0A401L5S8	D-amino-acid oxidase.	D-amino-acid oxidase.	0.891
AAWM_02026	AAWM_10284	A0A401KIT3	A0A401L7B3	D-amino-acid oxidase.	Trans-3-hydroxy-L-proline dehydratase.	0.607
AAWM_02447	AAWM_04228	A0A401KK95	A0A401KPX0	NADH-ubiquinone oxidoreductase 78 kDa subunit, mitochondrial; Belongs to the complex I 75 kDa subunit family.	Trans-L-3-hydroxyproline dehydratase.	0.540
AAWM_02447	AAWM_05552	A0A401KK95	A0A401KU02	NADH-ubiquinone oxidoreductase 78 kDa subunit, mitochondrial; Belongs to the complex I 75 kDa subunit family.	Proline racemase.	0.540
AAWM_02447	AAWM_08160	A0A401KK95	A0A401L121	NADH-ubiquinone oxidoreductase 78 kDa subunit, mitochondrial; Belongs to the complex I 75 kDa subunit family.	4-hydroxyproline 2-epimerase.	0.540
AAWM_02447	AAWM_10284	A0A401KK95	A0A401L7B3	NADH-ubiquinone oxidoreductase 78 kDa subunit, mitochondrial; Belongs to the complex I 75 kDa subunit family.	Trans-3-hydroxy-L-proline dehydratase.	0.540
AAWM_02594	AAWM_04228	A0A401KKJ1	A0A401KPX0	60 kDa lysophospholipase.	Trans-L-3-hydroxyproline dehydratase.	0.610
AAWM_02594	AAWM_05552	A0A401KKJ1	A0A401KU02	60 kDa lysophospholipase.	Proline racemase.	0.610
AAWM_02594	AAWM_08160	A0A401KKJ1	A0A401L121	60 kDa lysophospholipase.	4-hydroxyproline 2-epimerase.	0.610
AAWM_02594	AAWM_10284	A0A401KKJ1	A0A401L7B3	60 kDa lysophospholipase.	Trans-3-hydroxy-L-proline dehydratase.	0.610
AAWM_04228	AAWM_02026	A0A401KPX0	A0A401KIT3	Trans-L-3-hydroxyproline dehydratase.	D-amino-acid oxidase.	0.875
AAWM_04228	AAWM_02447	A0A401KPX0	A0A401KK95	Trans-L-3-hydroxyproline dehydratase.	NADH-ubiquinone oxidoreductase 78 kDa subunit, mitochondrial; Belongs to the complex I 75 kDa subunit family.	0.540
AAWM_04228	AAWM_02594	A0A401KPX0	A0A401KKJ1	Trans-L-3-hydroxyproline dehydratase.	60 kDa lysophospholipase.	0.610
AAWM_04228	AAWM_05552	A0A401KPX0	A0A401KU02	Trans-L-3-hydroxyproline dehydratase.	Proline racemase.	0.523
AAWM_04228	AAWM_06175	A0A401KPX0	A0A401KVI4	Trans-L-3-hydroxyproline dehydratase.	D-amino-acid oxidase.	0.837
AAWM_04228	AAWM_08160	A0A401KPX0	A0A401L121	Trans-L-3-hydroxyproline dehydratase.	4-hydroxyproline 2-epimerase.	0.428

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Network Stats

number of nodes:

11

number of edges:

19

average node degree:

3.45

avg. local clustering coefficient:

0.852

expected number of edges:

13

PPI enrichment p-value:

0.0832

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0035601

Protein deacylation

2 of 22

2.23

1.18

0.0155

GO:0006357

Regulation of transcription by RNA polymerase II

5 of 470

1.3

1.09

0.0030

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004407

Histone deacetylase activity

2 of 9

2.62

1.12

0.0213

GO:0000977

RNA polymerase II transcription regulatory region sequence-specific DNA binding

3 of 95

1.77

1.01

0.0213

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

3 of 233

1.38

0.8

0.0315

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:9511

Mixed, incl. Homeobox, and CCAAT-binding factor complex

3 of 27

2.31

2.01

0.00071

CL:2967

Rpd3S/Clr6-CII complex, and Sds3-like

2 of 6

2.79

1.66

0.0034

CL:9514

Mixed, incl. Homeobox, and Senescence-Associated Secretory Phenotype (SASP)

2 of 17

2.34

1.22

0.0140

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04213

Longevity regulating pathway - multiple species

2 of 11

2.53

1.67

0.0030

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00850

Histone deacetylase domain

2 of 4

2.97

1.62

0.0040

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR003084

Histone deacetylase

2 of 2

3.27

1.59

0.0045

IPR000286

Histone deacetylase family

2 of 3

3.09

1.59

0.0045

IPR037138

Histone deacetylase domain superfamily

2 of 4

2.97

1.58

0.0045

IPR023801

Histone deacetylase domain

2 of 4

2.97

1.58

0.0045

IPR023696

Ureohydrolase domain superfamily

2 of 10

2.57

1.34

0.0098

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