STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AAWM_05815DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1693 aa)    
Predicted Functional Partners:
AAWM_09621
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...]
   
 
 0.946
AAWM_01626
Structural maintenance of chromosomes protein.
   
 
 0.937
AAWM_09953
Uncharacterized protein.
   
 
 0.925
AAWM_05412
Ubiquitin-like protein SMT3.
    
 0.920
AAWM_09085
U4/U6.U5 small nuclear ribonucleoprotein component snu23.
 
 
 0.880
AAWM_00488
Structural maintenance of chromosomes protein.
   
 
 0.878
AAWM_09997
Condensin complex subunit 2; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes.
   
 
 0.878
AAWM_05943
Ubiquitin-conjugating enzyme E2-20 kDa; Belongs to the ubiquitin-conjugating enzyme family.
   
 0.867
AAWM_03876
Structural maintenance of chromosomes protein 6.
   
 
 0.847
AAWM_00559
Zinc finger MIZ domain-containing protein 2.
    
 0.828
Your Current Organism:
Aspergillus awamori
NCBI taxonomy Id: 105351
Other names: A. awamori, ATCC 16877, Aspergillus awamorii, Aspergillus niger var. awamori, Aspergillus niger var. awamorii, CBS 557.65, ITEM 4509
Server load: low (10%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.