AAWM_06583 protein (Aspergillus awamori) - STRING interaction network

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second shell of interactors

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Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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co-expression

protein homology

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Score

AAWM_06583

Uncharacterized transcriptional regulatory protein C530.05. (1192 aa)

Predicted Functional Partners:

AAWM_02957

0.550

AAWM_01884

0.523

AAWM_08926

0.505

AAWM_08393

0.499

AAWM_09767

0.469

AAWM_00564

0.446

AAWM_09656

0.440

AAWM_05205

0.439

AAWM_05412

0.420

AAWM_07598

0.415

Your Current Organism:

Aspergillus awamori

NCBI taxonomy Id: 105351
Other names: A. awamori, ATCC 16877, Aspergillus awamorii, Aspergillus niger var. awamori, Aspergillus niger var. awamorii, CBS 557.65, ITEM 4509

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AAWM_00564	AAWM_01884	A0A401KEN0	A0A401KIH3	26S proteasome regulatory subunit rpn11.	Tankyrase-1.	0.671
AAWM_00564	AAWM_02957	A0A401KEN0	A0A401KLP1	26S proteasome regulatory subunit rpn11.	Putative ankyrin repeat protein RF_0381.	0.580
AAWM_00564	AAWM_05412	A0A401KEN0	A0A401KTK4	26S proteasome regulatory subunit rpn11.	Ubiquitin-like protein SMT3.	0.785
AAWM_00564	AAWM_06583	A0A401KEN0	A0A401KWM1	26S proteasome regulatory subunit rpn11.	Uncharacterized transcriptional regulatory protein C530.05.	0.446
AAWM_00564	AAWM_07598	A0A401KEN0	A0A401KZG8	26S proteasome regulatory subunit rpn11.	E3 ubiquitin ligase complex SCF subunit sconC; Belongs to the SKP1 family.	0.812
AAWM_00564	AAWM_08393	A0A401KEN0	A0A401L1W9	26S proteasome regulatory subunit rpn11.	E3 ubiquitin-protein ligase MIB2.	0.410
AAWM_01884	AAWM_00564	A0A401KIH3	A0A401KEN0	Tankyrase-1.	26S proteasome regulatory subunit rpn11.	0.671
AAWM_01884	AAWM_02957	A0A401KIH3	A0A401KLP1	Tankyrase-1.	Putative ankyrin repeat protein RF_0381.	0.891
AAWM_01884	AAWM_05205	A0A401KIH3	A0A401KSP4	Tankyrase-1.	GRIP domain-containing protein C119.12.	0.662
AAWM_01884	AAWM_05412	A0A401KIH3	A0A401KTK4	Tankyrase-1.	Ubiquitin-like protein SMT3.	0.503
AAWM_01884	AAWM_06583	A0A401KIH3	A0A401KWM1	Tankyrase-1.	Uncharacterized transcriptional regulatory protein C530.05.	0.523
AAWM_01884	AAWM_07598	A0A401KIH3	A0A401KZG8	Tankyrase-1.	E3 ubiquitin ligase complex SCF subunit sconC; Belongs to the SKP1 family.	0.901
AAWM_01884	AAWM_08393	A0A401KIH3	A0A401L1W9	Tankyrase-1.	E3 ubiquitin-protein ligase MIB2.	0.728
AAWM_02957	AAWM_00564	A0A401KLP1	A0A401KEN0	Putative ankyrin repeat protein RF_0381.	26S proteasome regulatory subunit rpn11.	0.580
AAWM_02957	AAWM_01884	A0A401KLP1	A0A401KIH3	Putative ankyrin repeat protein RF_0381.	Tankyrase-1.	0.891
AAWM_02957	AAWM_05205	A0A401KLP1	A0A401KSP4	Putative ankyrin repeat protein RF_0381.	GRIP domain-containing protein C119.12.	0.804
AAWM_02957	AAWM_05412	A0A401KLP1	A0A401KTK4	Putative ankyrin repeat protein RF_0381.	Ubiquitin-like protein SMT3.	0.618
AAWM_02957	AAWM_06583	A0A401KLP1	A0A401KWM1	Putative ankyrin repeat protein RF_0381.	Uncharacterized transcriptional regulatory protein C530.05.	0.550
AAWM_02957	AAWM_07598	A0A401KLP1	A0A401KZG8	Putative ankyrin repeat protein RF_0381.	E3 ubiquitin ligase complex SCF subunit sconC; Belongs to the SKP1 family.	0.750
AAWM_02957	AAWM_08393	A0A401KLP1	A0A401L1W9	Putative ankyrin repeat protein RF_0381.	E3 ubiquitin-protein ligase MIB2.	0.988

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

26

PPI enrichment p-value:

3.38e-07

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006366

Transcription by RNA polymerase II

10 of 85

2.23

7.43

1.30e-18

GO:0001172

Transcription, RNA-templated

4 of 9

2.81

4.1

2.31e-08

GO:0098781

ncRNA transcription

4 of 14

2.62

3.74

8.55e-08

GO:0006360

Transcription by RNA polymerase I

4 of 20

2.46

3.46

2.12e-07

GO:0006383

Transcription by RNA polymerase III

4 of 21

2.44

3.43

2.30e-07

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003899

DNA-directed 5-3 RNA polymerase activity

7 of 24

2.63

6.87

2.51e-14

GO:0031369

Translation initiation factor binding

2 of 9

2.51

1.41

0.0026

GO:0003677

DNA binding

8 of 860

1.13

1.33

2.30e-06

GO:0003676

Nucleic acid binding

9 of 1578

0.92

0.94

7.20e-06

GO:1901363

Heterocyclic compound binding

10 of 3180

0.66

0.57

0.00014

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005665

RNA polymerase II, core complex

10 of 12

3.08

13.41

1.95e-26

GO:0005736

RNA polymerase I complex

4 of 12

2.68

4.21

1.11e-08

GO:0005666

RNA polymerase III complex

4 of 18

2.51

3.83

4.20e-08

GO:0005730

Nucleolus

5 of 273

1.42

1.64

2.40e-05

GO:0000932

P-body

2 of 30

1.98

1.14

0.0065

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:7704

RNA polymerase II, core complex

9 of 10

3.12

11.75

5.86e-23

CL:7706

RNA polymerase II, core complex

5 of 5

3.16

6.39

1.79e-12

CL:7670

Mixed, incl. RNA Polymerase II Pre-transcription Events, and RNA Polymerase III Transcription

11 of 178

1.95

6.21

1.71e-19

CL:7673

Mixed, incl. RNA Polymerase II Pre-transcription Events, and Tyrosinase activity

10 of 143

2.01

6.13

8.72e-18

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03020

RNA polymerase

10 of 40

2.56

10.33

5.92e-23

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-9018519

Estrogen-dependent gene expression

10 of 32

2.66

10.71

5.20e-23

MAP-77075

RNA Pol II CTD phosphorylation and interaction with CE

10 of 35

2.62

10.56

5.64e-23

MAP-72086

mRNA Capping

10 of 37

2.59

10.45

6.10e-23

MAP-113418

Formation of the Early Elongation Complex

10 of 39

2.57

10.34

7.26e-23

MAP-8939211

ESR-mediated signaling

10 of 43

2.53

10.06

1.38e-22

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0000428

DNA-directed RNA polymerase complex

8 of 81

2.16

5.58

1.06e-13

GOCC:0005665

RNA polymerase II, core complex

4 of 4

3.16

4.76

2.03e-09

GOCC:0055029

Nuclear DNA-directed RNA polymerase complex

5 of 59

2.09

3.37

6.38e-08

GOCC:0005736

RNA polymerase I complex

2 of 5

2.76

1.68

0.00086

GOCC:0031981

Nuclear lumen

5 of 561

1.11

0.9

0.0018

(more ...)

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036603

RNA polymerase, RBP11-like subunit

2 of 4

2.86

0.96

0.0186

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