node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AAWM_00502 | AAWM_00607 | A0A401KEA5 | A0A401KER6 | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. | ATP-dependent DNA helicase srs2. | 0.823 |
AAWM_00502 | AAWM_00755 | A0A401KEA5 | A0A401KEX0 | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. | Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. | 0.978 |
AAWM_00502 | AAWM_01202 | A0A401KEA5 | A0A401KGC4 | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. | Crossover junction endonuclease mus81. | 0.924 |
AAWM_00502 | AAWM_03387 | A0A401KEA5 | A0A401KML5 | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. | ATP-dependent DNA helicase hus2/rqh1. | 0.970 |
AAWM_00502 | AAWM_04467 | A0A401KEA5 | A0A401KQR7 | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. | DNA repair protein rad16. | 0.929 |
AAWM_00502 | AAWM_06809 | A0A401KEA5 | A0A401KXB0 | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. | 0.970 |
AAWM_00502 | AAWM_06889 | A0A401KEA5 | A0A401KXJ8 | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. | Mating-type switching protein swi10. | 0.521 |
AAWM_00502 | AAWM_08169 | A0A401KEA5 | A0A401L1B4 | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. | RecQ-mediated genome instability protein 1. | 0.948 |
AAWM_00502 | AAWM_09582 | A0A401KEA5 | A0A401L5E1 | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. | ATP-dependent DNA helicase mph1. | 0.915 |
AAWM_00502 | AAWM_10038 | A0A401KEA5 | A0A401L6G3 | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. | Werner syndrome ATP-dependent helicase homolog. | 0.997 |
AAWM_00607 | AAWM_00502 | A0A401KER6 | A0A401KEA5 | ATP-dependent DNA helicase srs2. | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. | 0.823 |
AAWM_00607 | AAWM_00755 | A0A401KER6 | A0A401KEX0 | ATP-dependent DNA helicase srs2. | Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. | 0.667 |
AAWM_00607 | AAWM_01202 | A0A401KER6 | A0A401KGC4 | ATP-dependent DNA helicase srs2. | Crossover junction endonuclease mus81. | 0.843 |
AAWM_00607 | AAWM_03387 | A0A401KER6 | A0A401KML5 | ATP-dependent DNA helicase srs2. | ATP-dependent DNA helicase hus2/rqh1. | 0.964 |
AAWM_00607 | AAWM_04467 | A0A401KER6 | A0A401KQR7 | ATP-dependent DNA helicase srs2. | DNA repair protein rad16. | 0.748 |
AAWM_00607 | AAWM_06809 | A0A401KER6 | A0A401KXB0 | ATP-dependent DNA helicase srs2. | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. | 0.964 |
AAWM_00607 | AAWM_08169 | A0A401KER6 | A0A401L1B4 | ATP-dependent DNA helicase srs2. | RecQ-mediated genome instability protein 1. | 0.751 |
AAWM_00607 | AAWM_09582 | A0A401KER6 | A0A401L5E1 | ATP-dependent DNA helicase srs2. | ATP-dependent DNA helicase mph1. | 0.932 |
AAWM_00607 | AAWM_10038 | A0A401KER6 | A0A401L6G3 | ATP-dependent DNA helicase srs2. | Werner syndrome ATP-dependent helicase homolog. | 0.920 |
AAWM_00755 | AAWM_00502 | A0A401KEX0 | A0A401KEA5 | Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. | 0.978 |