AAWM_09711 protein (Aspergillus awamori) - STRING interaction network

Nodes:

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second shell of interactors

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a 3D structure is known or predicted

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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[Homology]

Score

AAWM_09711

DUF1992 domain-containing protein. (482 aa)

Predicted Functional Partners:

AAWM_04925

0.692

AAWM_10583

0.692

AAWM_00635

0.665

AAWM_05610

0.665

AAWM_06908

0.535

AAWM_03154

0.457

AAWM_01152

0.456

AAWM_06470

0.455

AAWM_00610

0.453

AAWM_03891

0.453

Your Current Organism:

Aspergillus awamori

NCBI taxonomy Id: 105351
Other names: A. awamori, ATCC 16877, Aspergillus awamorii, Aspergillus niger var. awamori, Aspergillus niger var. awamorii, CBS 557.65, ITEM 4509

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AAWM_00610	AAWM_01152	A0A401KEU9	A0A401KG66	U3 small nucleolar RNA-associated protein 4.	Nucleolar protein 58.	0.998
AAWM_00610	AAWM_03154	A0A401KEU9	A0A401KM20	U3 small nucleolar RNA-associated protein 4.	U3 small nucleolar RNA-associated protein 20.	0.997
AAWM_00610	AAWM_03891	A0A401KEU9	A0A401KP33	U3 small nucleolar RNA-associated protein 4.	U3 small nucleolar RNA-associated protein 17.	0.999
AAWM_00610	AAWM_06470	A0A401KEU9	A0A401KWE4	U3 small nucleolar RNA-associated protein 4.	U3 small nucleolar RNA-associated protein 5.	0.999
AAWM_00610	AAWM_09711	A0A401KEU9	A0A401L5S1	U3 small nucleolar RNA-associated protein 4.	DUF1992 domain-containing protein.	0.453
AAWM_00635	AAWM_04925	A0A401KEK6	A0A401KRY1	Nitrate reductase [NADH] 1.	Glycerophosphodiester phosphodiesterase GDE1.	0.455
AAWM_00635	AAWM_05610	A0A401KEK6	A0A401KU06	Nitrate reductase [NADH] 1.	Nitrate reductase; Nitrate reductase is a key enzyme involved in the first step of nitrate assimilation in plants, fungi and bacteria.	0.969
AAWM_00635	AAWM_06908	A0A401KEK6	A0A401KXH8	Nitrate reductase [NADH] 1.	Ankyrin repeat protein nuc-2.	0.450
AAWM_00635	AAWM_09711	A0A401KEK6	A0A401L5S1	Nitrate reductase [NADH] 1.	DUF1992 domain-containing protein.	0.665
AAWM_00635	AAWM_10583	A0A401KEK6	A0A401L874	Nitrate reductase [NADH] 1.	Glycerophosphodiester phosphodiesterase GDE1.	0.455
AAWM_01152	AAWM_00610	A0A401KG66	A0A401KEU9	Nucleolar protein 58.	U3 small nucleolar RNA-associated protein 4.	0.998
AAWM_01152	AAWM_03154	A0A401KG66	A0A401KM20	Nucleolar protein 58.	U3 small nucleolar RNA-associated protein 20.	0.992
AAWM_01152	AAWM_03891	A0A401KG66	A0A401KP33	Nucleolar protein 58.	U3 small nucleolar RNA-associated protein 17.	0.998
AAWM_01152	AAWM_06470	A0A401KG66	A0A401KWE4	Nucleolar protein 58.	U3 small nucleolar RNA-associated protein 5.	0.998
AAWM_01152	AAWM_09711	A0A401KG66	A0A401L5S1	Nucleolar protein 58.	DUF1992 domain-containing protein.	0.456
AAWM_03154	AAWM_00610	A0A401KM20	A0A401KEU9	U3 small nucleolar RNA-associated protein 20.	U3 small nucleolar RNA-associated protein 4.	0.997
AAWM_03154	AAWM_01152	A0A401KM20	A0A401KG66	U3 small nucleolar RNA-associated protein 20.	Nucleolar protein 58.	0.992
AAWM_03154	AAWM_03891	A0A401KM20	A0A401KP33	U3 small nucleolar RNA-associated protein 20.	U3 small nucleolar RNA-associated protein 17.	0.998
AAWM_03154	AAWM_06470	A0A401KM20	A0A401KWE4	U3 small nucleolar RNA-associated protein 20.	U3 small nucleolar RNA-associated protein 5.	0.992
AAWM_03154	AAWM_09711	A0A401KM20	A0A401L5S1	U3 small nucleolar RNA-associated protein 20.	DUF1992 domain-containing protein.	0.457

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Network Stats

number of nodes:

11

number of edges:

34

average node degree:

6.18

avg. local clustering coefficient:

0.72

expected number of edges:

15

PPI enrichment p-value:

2.66e-05

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006094

Gluconeogenesis

3 of 29

2.38

2.19

7.07e-05

GO:0044283

Small molecule biosynthetic process

8 of 672

1.44

2.18

5.43e-08

GO:1901607

Alpha-amino acid biosynthetic process

5 of 201

1.76

2.17

1.04e-05

GO:0006096

Glycolytic process

4 of 108

1.94

2.03

6.07e-05

GO:0019284

L-methionine salvage from S-adenosylmethionine

2 of 3

3.19

2.02

0.00023

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016860

Intramolecular oxidoreductase activity

5 of 69

2.23

3.34

1.72e-07

GO:0004347

glucose-6-phosphate isomerase activity

3 of 3

3.37

3.26

1.28e-06

GO:0046570

Methylthioribulose 1-phosphate dehydratase activity

2 of 2

3.37

1.86

0.00044

GO:0043874

Acireductone synthase activity

2 of 2

3.37

1.86

0.00044

GO:0043716

2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase activity

2 of 2

3.37

1.86

0.00044

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:13634

L-serine biosynthetic process

3 of 11

2.8

2.33

5.40e-05

CL:13538

Mixed, incl. One carbon pool by folate, and De novo IMP biosynthetic process

4 of 59

2.2

2.19

5.40e-05

CL:14077

L-methionine salvage from S-adenosylmethionine, and S-methyl-5-thioribose kinase activity

2 of 5

2.97

1.3

0.0044

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

pda00030

Pentose phosphate pathway

2 of 70

1.82

0.76

0.0346

pda01200

Carbon metabolism

3 of 304

1.36

0.67

0.0346

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-70171

Glycolysis

4 of 86

2.04

2.17

3.83e-05

MAP-70326

Glucose metabolism

4 of 132

1.85

1.88

0.00010

MAP-70263

Gluconeogenesis

3 of 93

1.88

1.32

0.0023

MAP-977347

Serine biosynthesis

2 of 16

2.46

1.29

0.0043

MAP-5628897

TP53 Regulates Metabolic Genes

3 of 144

1.69

1.14

0.0043

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0312

Gluconeogenesis

2 of 2

3.37

1.94

0.00032

KW-0324

Glycolysis

2 of 47

2.0

0.8

0.0309

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00342

Phosphoglucose isomerase

2 of 2

3.37

1.48

0.0022

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