STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
top6BDNA topoisomerase VI, B subunit; Relaxes both positive and negative superturns and exhibits a strong decatenase activity. (684 aa)    
Predicted Functional Partners:
top6A
DNA topoisomerase VI, subunit A; Relaxes both positive and negative superturns and exhibits a strong decatenase activity; Belongs to the TOP6A family.
 
 
 0.989
AGI48204.1
Lactate dehydrogenase-related dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
 
    0.790
AGI47016.1
Orc1/cdc6 family replication initiation protein; Involved in regulation of DNA replication.
  
  
 0.541
dnaG
DNA primase (bacterial type); RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome.
  
   
 0.537
AGI48201.1
Hypothetical protein.
       0.533
atpF
Archaeal/vacuolar-type H+-ATPase subunit F; Produces ATP from ADP in the presence of a proton gradient across the membrane.
  
     0.523
rpl18e
LSU ribosomal protein L18AE; Belongs to the eukaryotic ribosomal protein eL18 family.
  
     0.518
AGI48517.1
Lhr-like helicase.
 
 
   0.486
rps17e
SSU ribosomal protein S17E; Belongs to the eukaryotic ribosomal protein eS17 family.
  
     0.474
AGI47304.1
Translation initiation factor 2, alpha subunit (eIF-2alpha).
   
 
 0.470
Your Current Organism:
Thermoplasmatales archaeon BRNA1
NCBI taxonomy Id: 1054217
Other names: T. archaeon BRNA1
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.