SHL17083.1 protein (Muricauda antarctica) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

SHL17083.1

Two component transcriptional regulator, LytTR family. (250 aa)

Predicted Functional Partners:

SHL17108.1

0.953

SHK19657.1

0.882

SHK99674.1

0.830

SHK57743.1

0.828

SHL20233.1

0.822

SHL13330.1

0.819

SHL49344.1

0.819

SHL20436.1

0.814

SHK19579.1

0.808

SHK20336.1

0.807

Your Current Organism:

Muricauda antarctica

NCBI taxonomy Id: 1055723
Other names: CGMCC 1.12174, JCM 18450, M. antarctica, Muricauda antarctica Wu et al. 2013, Muricauda sp. Ar-22, strain Ar-22

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SHK19579.1	SHK19657.1	SAMN05216293_0597	SAMN05216293_0599	7TM diverse intracellular signalling.	GAF domain-containing protein.	0.439
SHK19579.1	SHL13330.1	SAMN05216293_0597	SAMN05216293_2731	7TM diverse intracellular signalling.	Histidine kinase.	0.774
SHK19579.1	SHL17083.1	SAMN05216293_0597	SAMN05216293_2866	7TM diverse intracellular signalling.	Two component transcriptional regulator, LytTR family.	0.808
SHK19579.1	SHL20436.1	SAMN05216293_0597	SAMN05216293_2897	7TM diverse intracellular signalling.	Histidine kinase.	0.773
SHK19657.1	SHK19579.1	SAMN05216293_0599	SAMN05216293_0597	GAF domain-containing protein.	7TM diverse intracellular signalling.	0.439
SHK19657.1	SHK20336.1	SAMN05216293_0599	SAMN05216293_0622	GAF domain-containing protein.	7TM diverse intracellular signalling.	0.438
SHK19657.1	SHK57743.1	SAMN05216293_0599	SAMN05216293_1426	GAF domain-containing protein.	Histidine kinase.	0.435
SHK19657.1	SHK99674.1	SAMN05216293_0599	SAMN05216293_2397	GAF domain-containing protein.	Histidine kinase.	0.438
SHK19657.1	SHL13330.1	SAMN05216293_0599	SAMN05216293_2731	GAF domain-containing protein.	Histidine kinase.	0.439
SHK19657.1	SHL17083.1	SAMN05216293_0599	SAMN05216293_2866	GAF domain-containing protein.	Two component transcriptional regulator, LytTR family.	0.882
SHK19657.1	SHL17108.1	SAMN05216293_0599	SAMN05216293_2867	GAF domain-containing protein.	7TM diverse intracellular signalling.	0.433
SHK19657.1	SHL20233.1	SAMN05216293_0599	SAMN05216293_2888	GAF domain-containing protein.	Histidine kinase.	0.437
SHK19657.1	SHL20436.1	SAMN05216293_0599	SAMN05216293_2897	GAF domain-containing protein.	Histidine kinase.	0.786
SHK19657.1	SHL49344.1	SAMN05216293_0599	SAMN05216293_3560	GAF domain-containing protein.	Histidine kinase.	0.438
SHK20336.1	SHK19657.1	SAMN05216293_0622	SAMN05216293_0599	7TM diverse intracellular signalling.	GAF domain-containing protein.	0.438
SHK20336.1	SHL17083.1	SAMN05216293_0622	SAMN05216293_2866	7TM diverse intracellular signalling.	Two component transcriptional regulator, LytTR family.	0.807
SHK57743.1	SHK19657.1	SAMN05216293_1426	SAMN05216293_0599	Histidine kinase.	GAF domain-containing protein.	0.435
SHK57743.1	SHL17083.1	SAMN05216293_1426	SAMN05216293_2866	Histidine kinase.	Two component transcriptional regulator, LytTR family.	0.828
SHK99674.1	SHK19657.1	SAMN05216293_2397	SAMN05216293_0599	Histidine kinase.	GAF domain-containing protein.	0.438
SHK99674.1	SHL17083.1	SAMN05216293_2397	SAMN05216293_2866	Histidine kinase.	Two component transcriptional regulator, LytTR family.	0.830

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

32

average node degree:

5.82

avg. local clustering coefficient:

0.787

expected number of edges:

12

PPI enrichment p-value:

1.64e-06

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0033554

Cellular response to stress

7 of 44

1.37

1.69

5.36e-06

GO:0006281

DNA repair

6 of 32

1.44

1.68

2.10e-05

GO:0009432

SOS response

4 of 12

1.69

1.61

0.00026

GO:0006310

DNA recombination

4 of 13

1.66

1.57

0.00030

GO:0090304

Nucleic acid metabolic process

7 of 149

0.84

0.69

0.0010

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0140097

Catalytic activity, acting on DNA

6 of 37

1.38

1.57

2.58e-05

GO:0140640

Catalytic activity, acting on a nucleic acid

8 of 105

1.05

1.09

2.58e-05

GO:0008094

ATP-dependent activity, acting on DNA

3 of 12

1.57

0.97

0.0089

GO:0009378

Four-way junction helicase activity

2 of 2

2.17

0.93

0.0183

GO:0003677

DNA binding

6 of 101

0.94

0.73

0.0027

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009379

Holliday junction helicase complex

2 of 2

2.17

0.99

0.0145

GO:1905347

Endodeoxyribonuclease complex

2 of 6

1.69

0.86

0.0190

GO:1902494

Catalytic complex

4 of 43

1.14

0.71

0.0145

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:464

Holliday junction helicase complex, and Peroxiredoxin, AhpC-type

5 of 5

2.17

3.32

1.40e-07

CL:462

Mixed, incl. Pyridoxal phosphate metabolic process, and Holliday junction helicase complex

6 of 10

1.95

3.31

2.43e-08

CL:400

Catalytic activity, acting on DNA, and DNA damage

9 of 41

1.51

2.73

2.09e-10

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03440

Homologous recombination

5 of 20

1.57

1.81

2.80e-05

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:1905347

Endodeoxyribonuclease complex

3 of 8

1.74

1.05

0.0076

GOCC:0048476

Holliday junction resolvase complex

2 of 2

2.17

0.95

0.0170

GOCC:0009379

Holliday junction helicase complex

2 of 4

1.87

0.83

0.0253

GOCC:1902494

Catalytic complex

5 of 99

0.87

0.55

0.0170

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0742

SOS response

4 of 7

1.93

2.09

4.08e-05

KW-0233

DNA recombination

4 of 9

1.82

2.01

4.08e-05

KW-0234

DNA repair

5 of 20

1.57

1.76

4.08e-05

KW-0227

DNA damage

5 of 20

1.57

1.76

4.08e-05

KW-0347

Helicase

2 of 7

1.62

0.66

0.0491

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (16%) [HD]

Permalink

Network

Neighborhood

Experiments

Cooccurrence

Databases

Coexpression

Textmining

Fusion

© STRING Consortium 2024

Credits

Access

Info

About