STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AFZ70388.1ABC-type branched-chain amino acid transport system, periplasmic component. (430 aa)    
Predicted Functional Partners:
AFZ70389.1
PFAM: ABC transporter; Branched-chain amino acid ATP-binding cassette transporter.
 
 
 0.995
AFZ70390.1
ABC-type branched-chain amino acid transport systems, ATPase component; PFAM: ABC transporter.
 
 
 0.995
AFZ70391.1
PFAM: Branched-chain amino acid transport system / permease component.
 
 
 0.994
AFZ70392.1
PFAM: Branched-chain amino acid transport system / permease component.
 
 
 0.994
AFZ70397.1
ABC-type branched-chain amino acid transport system, periplasmic component; PFAM: Receptor family ligand binding region.
  
  
 
0.901
AFZ70386.1
PFAM: Pyruvate kinase, barrel domain; Pyruvate kinase, alpha/beta domain; TIGRFAM: pyruvate kinase; Belongs to the pyruvate kinase family.
       0.627
AFZ70387.1
Putative nucleotidyltransferase; PFAM: Conserved Archaeal protein (DUF2204).
       0.601
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
  
 
 0.439
AFZ70053.1
PFAM: CBS domain; Voltage gated chloride channel.
 
   
 0.419
AFZ70489.1
Mn2+/Fe2- transporter, NRAMP family; PFAM: Natural resistance-associated macrophage protein; TIGRFAM: NRAMP (natural resistance-associated macrophage protein) metal ion transporters.
 
   
 0.415
Your Current Organism:
Caldisphaera lagunensis
NCBI taxonomy Id: 1056495
Other names: C. lagunensis DSM 15908, Caldisphaera lagunensis DSM 15908, Caldisphaera lagunensis IC-154, Caldisphaera lagunensis JCM 11604, Caldisphaera lagunensis str. DSM 15908, Caldisphaera lagunensis strain DSM 15908
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.