node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SDW02163.1 | SDW71687.1 | SAMN05421783_101113 | SAMN05421783_107165 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Precorrin-4/cobalt-precorrin-4 C11-methyltransferase; Belongs to the precorrin methyltransferase family. | 0.701 |
SDW02163.1 | SDW77096.1 | SAMN05421783_101113 | SAMN05421783_10897 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Protoporphyrinogen oxidase. | 0.617 |
SDW02163.1 | SDX24607.1 | SAMN05421783_101113 | SAMN05421783_11859 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Modular FeS cluster scaffolding protein NifU; May be involved in the formation or repair of [Fe-S] clusters present in iron-sulfur proteins. | 0.617 |
SDW02163.1 | SDX24710.1 | SAMN05421783_101113 | SAMN05421783_11864 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | precorrin-6Y C5,15-methyltransferase (decarboxylating). | 0.672 |
SDW02163.1 | SDX24724.1 | SAMN05421783_101113 | SAMN05421783_11865 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Precorrin-2 C20-methyltransferase /cobalt-factor II C20-methyltransferase. | 0.664 |
SDW02163.1 | SDX53514.1 | SAMN05421783_101113 | SAMN05421783_13417 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Sirohydrochlorin ferrochelatase. | 0.658 |
SDW02163.1 | cysG | SAMN05421783_101113 | SAMN05421783_11824 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | uroporphyrin-III C-methyltransferase / precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | 0.969 |
SDW02314.1 | SDX53514.1 | SAMN05421783_101120 | SAMN05421783_13417 | Nucleoside-diphosphate-sugar epimerase. | Sirohydrochlorin ferrochelatase. | 0.896 |
SDW71661.1 | SDW71687.1 | SAMN05421783_107164 | SAMN05421783_107165 | Hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing) /cobyrinate a,c-diamide synthase. | Precorrin-4/cobalt-precorrin-4 C11-methyltransferase; Belongs to the precorrin methyltransferase family. | 0.939 |
SDW71661.1 | SDX24710.1 | SAMN05421783_107164 | SAMN05421783_11864 | Hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing) /cobyrinate a,c-diamide synthase. | precorrin-6Y C5,15-methyltransferase (decarboxylating). | 0.882 |
SDW71661.1 | SDX24724.1 | SAMN05421783_107164 | SAMN05421783_11865 | Hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing) /cobyrinate a,c-diamide synthase. | Precorrin-2 C20-methyltransferase /cobalt-factor II C20-methyltransferase. | 0.872 |
SDW71661.1 | SDX53514.1 | SAMN05421783_107164 | SAMN05421783_13417 | Hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing) /cobyrinate a,c-diamide synthase. | Sirohydrochlorin ferrochelatase. | 0.590 |
SDW71661.1 | cbiA | SAMN05421783_107164 | SAMN05421783_10248 | Hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing) /cobyrinate a,c-diamide synthase. | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | 0.845 |
SDW71661.1 | cysG | SAMN05421783_107164 | SAMN05421783_11824 | Hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing) /cobyrinate a,c-diamide synthase. | uroporphyrin-III C-methyltransferase / precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | 0.655 |
SDW71687.1 | SDW02163.1 | SAMN05421783_107165 | SAMN05421783_101113 | Precorrin-4/cobalt-precorrin-4 C11-methyltransferase; Belongs to the precorrin methyltransferase family. | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.701 |
SDW71687.1 | SDW71661.1 | SAMN05421783_107165 | SAMN05421783_107164 | Precorrin-4/cobalt-precorrin-4 C11-methyltransferase; Belongs to the precorrin methyltransferase family. | Hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing) /cobyrinate a,c-diamide synthase. | 0.939 |
SDW71687.1 | SDX24607.1 | SAMN05421783_107165 | SAMN05421783_11859 | Precorrin-4/cobalt-precorrin-4 C11-methyltransferase; Belongs to the precorrin methyltransferase family. | Modular FeS cluster scaffolding protein NifU; May be involved in the formation or repair of [Fe-S] clusters present in iron-sulfur proteins. | 0.539 |
SDW71687.1 | SDX24710.1 | SAMN05421783_107165 | SAMN05421783_11864 | Precorrin-4/cobalt-precorrin-4 C11-methyltransferase; Belongs to the precorrin methyltransferase family. | precorrin-6Y C5,15-methyltransferase (decarboxylating). | 0.998 |
SDW71687.1 | SDX24724.1 | SAMN05421783_107165 | SAMN05421783_11865 | Precorrin-4/cobalt-precorrin-4 C11-methyltransferase; Belongs to the precorrin methyltransferase family. | Precorrin-2 C20-methyltransferase /cobalt-factor II C20-methyltransferase. | 0.993 |
SDW71687.1 | SDX53514.1 | SAMN05421783_107165 | SAMN05421783_13417 | Precorrin-4/cobalt-precorrin-4 C11-methyltransferase; Belongs to the precorrin methyltransferase family. | Sirohydrochlorin ferrochelatase. | 0.618 |