STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SIR2NAD-dependent histone deacetylase sir2. (644 aa)    
Predicted Functional Partners:
HHF1_1
Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
   
 0.920
EHS24_007026
CTP_transf_like domain-containing protein.
    
 0.884
HST2
Sir2 histone deacetylase Hst2.
  
 
0.883
PNC1
NAD(+) salvage pathway protein.
   
 0.880
EHS24_000630
Uncharacterized protein.
    
 0.865
RRP8
Ribosomal RNA-processing protein 8; S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of adenine in helix 25.1 in 25S rRNA. Required both for ribosomal 40S and 60S subunits biogenesis. Required for efficient pre-rRNA cleavage at site A2. Belongs to the methyltransferase superfamily. RRP8 family.
    
 0.841
QNS1
Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family.
    
 0.832
EHS24_007594
SANT domain-containing protein.
   
 
 0.817
EHS24_005334
Deacetylase sirtuin-type domain-containing protein.
   
 
 0.809
URH1
Uridine nucleosidase 1.
   
 
 0.809
Your Current Organism:
Apiotrichum porosum
NCBI taxonomy Id: 105984
Other names: A. porosum, CBS 2040, NRRL Y-17198, Trichosporon porosum, Trichosporon sp. ICMP 16990, Trichosporon sp. ICMP 16991, Trichosporon sp. SJ13S15, Trichosporon sp. SJ15S11, VKM Y-3
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.