A0A1Y2EXB8 protein (Leucosporidium creatinivorum)

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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co-expression

protein homology

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Score

A0A1Y2EXB8

Fatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family. (362 aa)

Predicted Functional Partners:

A0A1Y2FTZ9

0.955

A0A1Y2C6Z3

0.940

A0A1Y2D645

0.930

A0A1Y2F3G9

0.915

A0A1Y2EUE7

0.908

A0A1Y2FW46

0.900

A0A1Y2FYY5

0.889

A0A1Y2G643

0.889

A0A1Y2EQK1

0.883

A0A1Y2EUW9

0.762

Your Current Organism:

Leucosporidium creatinivorum

NCBI taxonomy Id: 106004
Other names: CBS 8620, L. creatinivorum, Leucosporidiella creatinivora, Leucosporidiella creatinivora (Golubev) J.P. Samp., 2003, Leucosporidium creatinivorum (Golubev) V. de Garcia, M. A. Coelho, T. Maia, L. H. Rosa, A. M. Vaz, C. A. Rosa, J. P. Sampaio, P. Goncalves, M. R. van Broock andD. Libkind, 2015, Rhodotorula creatinivora, Rhodotorula creatinovora, VKM Y-2838

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A1Y2C6Z3	A0A1Y2D645	Uncharacterized protein.	TLC domain-domain-containing protein.	0.919
A0A1Y2C6Z3	A0A1Y2EQK1	Uncharacterized protein.	Ceramidase.	0.935
A0A1Y2C6Z3	A0A1Y2EUE7	Uncharacterized protein.	Ceramide very long chain fatty acid hydroxylase; Ceramide hydroxylase involved in the hydroxylation of sphingolipid-associated very long chain fatty acids. Postulated to hydroxylate the very long chain fatty acid of dihydroceramides and phytoceramides at C-2; Belongs to the sterol desaturase family. SCS7 subfamily.	0.531
A0A1Y2C6Z3	A0A1Y2EXB8	Uncharacterized protein.	Fatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family.	0.940
A0A1Y2C6Z3	A0A1Y2F3G9	Uncharacterized protein.	TLC domain-domain-containing protein.	0.901
A0A1Y2C6Z3	A0A1Y2FTZ9	Uncharacterized protein.	Phosphatidic acid phosphatase type 2/haloperoxidase.	0.933
A0A1Y2C6Z3	A0A1Y2FW46	Uncharacterized protein.	Sphingolipid delta(4)-desaturase; Delta(4)-fatty-acid desaturase which introduces a double bond at the 4-position in the long-chain base (LCB) of ceramides.	0.941
A0A1Y2C6Z3	A0A1Y2FYY5	Uncharacterized protein.	ATP-NAD kinase-like domain-containing protein.	0.852
A0A1Y2C6Z3	A0A1Y2G643	Uncharacterized protein.	ATP-NAD kinase-like domain-containing protein.	0.852
A0A1Y2D645	A0A1Y2C6Z3	TLC domain-domain-containing protein.	Uncharacterized protein.	0.919
A0A1Y2D645	A0A1Y2EQK1	TLC domain-domain-containing protein.	Ceramidase.	0.914
A0A1Y2D645	A0A1Y2EUE7	TLC domain-domain-containing protein.	Ceramide very long chain fatty acid hydroxylase; Ceramide hydroxylase involved in the hydroxylation of sphingolipid-associated very long chain fatty acids. Postulated to hydroxylate the very long chain fatty acid of dihydroceramides and phytoceramides at C-2; Belongs to the sterol desaturase family. SCS7 subfamily.	0.489
A0A1Y2D645	A0A1Y2EXB8	TLC domain-domain-containing protein.	Fatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family.	0.930
A0A1Y2D645	A0A1Y2F3G9	TLC domain-domain-containing protein.	TLC domain-domain-containing protein.	0.879
A0A1Y2D645	A0A1Y2FTZ9	TLC domain-domain-containing protein.	Phosphatidic acid phosphatase type 2/haloperoxidase.	0.933
A0A1Y2D645	A0A1Y2FW46	TLC domain-domain-containing protein.	Sphingolipid delta(4)-desaturase; Delta(4)-fatty-acid desaturase which introduces a double bond at the 4-position in the long-chain base (LCB) of ceramides.	0.928
A0A1Y2D645	A0A1Y2FYY5	TLC domain-domain-containing protein.	ATP-NAD kinase-like domain-containing protein.	0.829
A0A1Y2D645	A0A1Y2G643	TLC domain-domain-containing protein.	ATP-NAD kinase-like domain-containing protein.	0.829
A0A1Y2EQK1	A0A1Y2C6Z3	Ceramidase.	Uncharacterized protein.	0.935
A0A1Y2EQK1	A0A1Y2D645	Ceramidase.	TLC domain-domain-containing protein.	0.914

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

34

average node degree:

6.18

avg. local clustering coefficient:

0.915

expected number of edges:

10

PPI enrichment p-value:

2.83e-09

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0051382

Kinetochore assembly

3 of 12

2.72

1.93

0.00029

GO:0007059

Chromosome segregation

5 of 220

1.68

1.59

0.00029

GO:0000712

Resolution of meiotic recombination intermediates

2 of 17

2.4

0.87

0.0257

GO:0036297

Interstrand cross-link repair

2 of 25

2.23

0.81

0.0327

GO:0031297

Replication fork processing

2 of 29

2.16

0.78

0.0359

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0080122

AMP transmembrane transporter activity

2 of 4

3.02

1.16

0.0082

GO:0015228

Coenzyme A transmembrane transporter activity

2 of 4

3.02

1.16

0.0082

GO:0043262

Adenosine-diphosphatase activity

2 of 7

2.78

1.15

0.0082

GO:0015217

ADP transmembrane transporter activity

2 of 9

2.67

1.15

0.0082

GO:0005347

ATP transmembrane transporter activity

2 of 16

2.42

1.01

0.0140

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000775

Chromosome, centromeric region

5 of 150

1.85

2.32

7.01e-06

GO:0071821

FANCM-MHF complex

2 of 5

2.93

1.58

0.0014

GO:0043240

Fanconi anaemia nuclear complex

2 of 9

2.67

1.4

0.0028

GO:0000776

Kinetochore

3 of 101

1.8

1.24

0.0030

GO:0005694

Chromosome

6 of 900

1.15

1.03

0.00057

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:4083

Centromere complex assembly, and AMP transport

7 of 16

2.97

8.07

5.63e-16

CL:4087

Centromere complex assembly, and Inner kinetochore

6 of 11

3.06

7.34

2.20e-14

CL:4090

Centromere complex assembly, and Inner kinetochore

3 of 6

3.02

3.0

3.36e-06

CL:2471

Fanconi anaemia nuclear complex, and CENP-S protein

2 of 12

2.55

1.13

0.0085

CL:2198

DNA replication, and Fanconi anemia pathway

3 of 165

1.58

0.8

0.0229

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

sdu03460

Fanconi anemia pathway

2 of 46

1.96

0.76

0.0376

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-774815

Nucleosome assembly

5 of 62

2.23

3.39

1.30e-07

MAP-606279

Deposition of new CENPA-containing nucleosomes at the centromere

5 of 62

2.23

3.39

1.30e-07

MAP-73886

Chromosome Maintenance

5 of 129

1.91

2.64

1.47e-06

MAP-499943

Interconversion of nucleotide di- and triphosphates

3 of 43

2.17

1.72

0.00049

MAP-141444

Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal

3 of 108

1.77

1.11

0.0057

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0071821

FANCM-MHF complex

2 of 5

2.93

1.44

0.0025

GOCC:0000779

Condensed chromosome, centromeric region

3 of 48

2.12

1.36

0.0025

GOCC:0000776

Kinetochore

3 of 54

2.07

1.35

0.0025

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