A0A1Y2FG04 protein (Leucosporidium creatinivorum)

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query proteins and first shell of interactors

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second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

A0A1Y2FG04

Uncharacterized protein. (1941 aa)

Predicted Functional Partners:

A0A1Y2FXY2

0.964

A0A1Y2FSA0

0.716

A0A1Y2G2N2

0.648

A0A1Y2FMW8

0.546

A0A1Y2E906

0.492

A0A1Y2F421

0.492

A0A1Y2F4M2

0.483

A0A1Y2G2W8

0.483

A0A1Y2F062

0.457

A0A1Y2ECW6

0.449

Your Current Organism:

Leucosporidium creatinivorum

NCBI taxonomy Id: 106004
Other names: CBS 8620, L. creatinivorum, Leucosporidiella creatinivora, Leucosporidiella creatinivora (Golubev) J.P. Samp., 2003, Leucosporidium creatinivorum (Golubev) V. de Garcia, M. A. Coelho, T. Maia, L. H. Rosa, A. M. Vaz, C. A. Rosa, J. P. Sampaio, P. Goncalves, M. R. van Broock andD. Libkind, 2015, Rhodotorula creatinivora, Rhodotorula creatinovora, VKM Y-2838

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A1Y2E906	A0A1Y2F062	P-loop containing nucleoside triphosphate hydrolase protein.	Rab-GTPase-TBC domain-domain-containing protein.	0.412
A0A1Y2E906	A0A1Y2F4M2	P-loop containing nucleoside triphosphate hydrolase protein.	Uncharacterized protein.	0.625
A0A1Y2E906	A0A1Y2FG04	P-loop containing nucleoside triphosphate hydrolase protein.	Uncharacterized protein.	0.492
A0A1Y2E906	A0A1Y2G2N2	P-loop containing nucleoside triphosphate hydrolase protein.	RIC1-domain-containing protein.	0.748
A0A1Y2E906	A0A1Y2G2W8	P-loop containing nucleoside triphosphate hydrolase protein.	P-loop containing nucleoside triphosphate hydrolase protein.	0.625
A0A1Y2ECW6	A0A1Y2FG04	Uncharacterized protein.	Uncharacterized protein.	0.449
A0A1Y2F062	A0A1Y2E906	Rab-GTPase-TBC domain-domain-containing protein.	P-loop containing nucleoside triphosphate hydrolase protein.	0.412
A0A1Y2F062	A0A1Y2F421	Rab-GTPase-TBC domain-domain-containing protein.	ADP-ribosylation factor family-domain-containing protein; Belongs to the small GTPase superfamily. Arf family.	0.412
A0A1Y2F062	A0A1Y2FG04	Rab-GTPase-TBC domain-domain-containing protein.	Uncharacterized protein.	0.457
A0A1Y2F062	A0A1Y2G2N2	Rab-GTPase-TBC domain-domain-containing protein.	RIC1-domain-containing protein.	0.435
A0A1Y2F421	A0A1Y2F062	ADP-ribosylation factor family-domain-containing protein; Belongs to the small GTPase superfamily. Arf family.	Rab-GTPase-TBC domain-domain-containing protein.	0.412
A0A1Y2F421	A0A1Y2F4M2	ADP-ribosylation factor family-domain-containing protein; Belongs to the small GTPase superfamily. Arf family.	Uncharacterized protein.	0.625
A0A1Y2F421	A0A1Y2FG04	ADP-ribosylation factor family-domain-containing protein; Belongs to the small GTPase superfamily. Arf family.	Uncharacterized protein.	0.492
A0A1Y2F421	A0A1Y2G2N2	ADP-ribosylation factor family-domain-containing protein; Belongs to the small GTPase superfamily. Arf family.	RIC1-domain-containing protein.	0.748
A0A1Y2F421	A0A1Y2G2W8	ADP-ribosylation factor family-domain-containing protein; Belongs to the small GTPase superfamily. Arf family.	P-loop containing nucleoside triphosphate hydrolase protein.	0.625
A0A1Y2F4M2	A0A1Y2E906	Uncharacterized protein.	P-loop containing nucleoside triphosphate hydrolase protein.	0.625
A0A1Y2F4M2	A0A1Y2F421	Uncharacterized protein.	ADP-ribosylation factor family-domain-containing protein; Belongs to the small GTPase superfamily. Arf family.	0.625
A0A1Y2F4M2	A0A1Y2FG04	Uncharacterized protein.	Uncharacterized protein.	0.483
A0A1Y2F4M2	A0A1Y2FMW8	Uncharacterized protein.	SEC7 domain-containing protein.	0.419
A0A1Y2F4M2	A0A1Y2G2N2	Uncharacterized protein.	RIC1-domain-containing protein.	0.512

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

41

average node degree:

7.45

avg. local clustering coefficient:

0.833

expected number of edges:

10

PPI enrichment p-value:

8.16e-13

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009073

Aromatic amino acid family biosynthetic process

7 of 15

2.3

5.28

6.31e-12

GO:0046417

Chorismate metabolic process

4 of 6

2.46

3.07

1.32e-06

GO:0009423

Chorismate biosynthetic process

3 of 5

2.41

2.27

5.21e-05

GO:0009095

Aromatic amino acid family biosynthetic process, prephenate pathway

2 of 2

2.63

1.51

0.0017

GO:0008652

Cellular amino acid biosynthetic process

5 of 108

1.3

1.27

0.00023

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016838

Carbon-oxygen lyase activity, acting on phosphates

3 of 6

2.33

1.74

0.00054

GO:0003856

3-dehydroquinate synthase activity

2 of 2

2.63

1.26

0.0051

GO:0016835

Carbon-oxygen lyase activity

4 of 52

1.52

1.2

0.0019

GO:0016829

Lyase activity

5 of 130

1.22

0.99

0.0019

GO:0003824

Catalytic activity

11 of 2283

0.32

0.24

0.0462

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1157

Aromatic amino acid family biosynthetic process, and Anthranilate synthase component I-like

9 of 19

2.31

7.07

1.22e-16

CL:1159

Chorismate biosynthetic process

4 of 6

2.46

3.31

4.40e-07

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

zga00400

Phenylalanine, tyrosine and tryptophan biosynthesis

10 of 23

2.27

8.0

6.95e-20

zga01230

Biosynthesis of amino acids

10 of 125

1.54

3.22

1.45e-13

zga01110

Biosynthesis of secondary metabolites

11 of 326

1.16

1.77

7.18e-12

zga01100

Metabolic pathways

11 of 716

0.82

0.89

2.77e-08

zga02024

Quorum sensing

2 of 26

1.52

0.69

0.0386

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005737

Cytoplasm

9 of 1110

0.54

0.36

0.0243

GOCC:0005622

Intracellular

10 of 1523

0.45

0.31

0.0243

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0057

Aromatic amino acid biosynthesis

3 of 11

2.07

1.76

0.00034

KW-0456

Lyase

6 of 116

1.35

1.54

2.15e-05

KW-0170

Cobalt

2 of 4

2.33

1.25

0.0049

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00425

Chorismate binding enzyme

2 of 3

2.46

0.82

0.0315

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR030963

3-dehydroquinate synthase family

2 of 2

2.63

0.74

0.0466

IPR030960

3-dehydroquinate synthase domain

2 of 2

2.63

0.74

0.0466

IPR015890

Chorismate-utilising enzyme, C-terminal

2 of 3

2.46

0.73

0.0466

IPR005801

ADC synthase

2 of 3

2.46

0.73

0.0466

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