A0A1Y2FVU5 protein (Leucosporidium creatinivorum)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

Edges:

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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Score

A0A1Y2FVU5

ANK_REP_REGION domain-containing protein. (219 aa)

Predicted Functional Partners:

A0A1Y2G3E9

0.971

A0A1Y2CI20

0.764

A0A1Y2DDS0

0.731

A0A1Y2F3R8

0.703

A0A1Y2F4S6

0.703

A0A1Y2EPD4

0.695

A0A1Y2FRS6

0.658

A0A1Y2FXZ8

0.649

A0A1Y2G175

0.638

A0A1Y2FZ48

0.632

Your Current Organism:

Leucosporidium creatinivorum

NCBI taxonomy Id: 106004
Other names: CBS 8620, L. creatinivorum, Leucosporidiella creatinivora, Leucosporidiella creatinivora (Golubev) J.P. Samp., 2003, Leucosporidium creatinivorum (Golubev) V. de Garcia, M. A. Coelho, T. Maia, L. H. Rosa, A. M. Vaz, C. A. Rosa, J. P. Sampaio, P. Goncalves, M. R. van Broock andD. Libkind, 2015, Rhodotorula creatinivora, Rhodotorula creatinovora, VKM Y-2838

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A1Y2CI20	A0A1Y2DDS0	Low temperature viability protein-domain-containing protein.	Pre-rRNA-processing protein TSR2-domain-containing protein.	0.797
A0A1Y2CI20	A0A1Y2EPD4	Low temperature viability protein-domain-containing protein.	Uncharacterized protein.	0.438
A0A1Y2CI20	A0A1Y2FVU5	Low temperature viability protein-domain-containing protein.	ANK_REP_REGION domain-containing protein.	0.764
A0A1Y2CI20	A0A1Y2G3E9	Low temperature viability protein-domain-containing protein.	Ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family.	0.996
A0A1Y2DDS0	A0A1Y2CI20	Pre-rRNA-processing protein TSR2-domain-containing protein.	Low temperature viability protein-domain-containing protein.	0.797
A0A1Y2DDS0	A0A1Y2EPD4	Pre-rRNA-processing protein TSR2-domain-containing protein.	Uncharacterized protein.	0.689
A0A1Y2DDS0	A0A1Y2FVU5	Pre-rRNA-processing protein TSR2-domain-containing protein.	ANK_REP_REGION domain-containing protein.	0.731
A0A1Y2EPD4	A0A1Y2CI20	Uncharacterized protein.	Low temperature viability protein-domain-containing protein.	0.438
A0A1Y2EPD4	A0A1Y2DDS0	Uncharacterized protein.	Pre-rRNA-processing protein TSR2-domain-containing protein.	0.689
A0A1Y2EPD4	A0A1Y2F3R8	Uncharacterized protein.	SPX domain-containing protein.	0.604
A0A1Y2EPD4	A0A1Y2F4S6	Uncharacterized protein.	Uncharacterized protein.	0.604
A0A1Y2EPD4	A0A1Y2FVU5	Uncharacterized protein.	ANK_REP_REGION domain-containing protein.	0.695
A0A1Y2EPD4	A0A1Y2G3E9	Uncharacterized protein.	Ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family.	0.822
A0A1Y2F3R8	A0A1Y2EPD4	SPX domain-containing protein.	Uncharacterized protein.	0.604
A0A1Y2F3R8	A0A1Y2F4S6	SPX domain-containing protein.	Uncharacterized protein.	0.999
A0A1Y2F3R8	A0A1Y2FRS6	SPX domain-containing protein.	Serine/threonine-protein phosphatase.	0.974
A0A1Y2F3R8	A0A1Y2FVU5	SPX domain-containing protein.	ANK_REP_REGION domain-containing protein.	0.703
A0A1Y2F3R8	A0A1Y2FXZ8	SPX domain-containing protein.	Ubiquitin carboxyl-terminal hydrolase.	0.649
A0A1Y2F3R8	A0A1Y2FZ48	SPX domain-containing protein.	3'-5' exonuclease domain-containing protein.	0.659
A0A1Y2F3R8	A0A1Y2G175	SPX domain-containing protein.	Uncharacterized protein.	0.662

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

11

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0036068

Light-independent chlorophyll biosynthetic process

5 of 6

2.47

3.89

2.73e-08

GO:0015994

Chlorophyll metabolic process

6 of 20

2.02

3.42

2.73e-08

GO:0036070

Light-independent bacteriochlorophyll biosynthetic process

4 of 5

2.45

3.15

8.95e-07

GO:0015979

Photosynthesis

6 of 27

1.89

3.14

4.34e-08

GO:0019685

Photosynthesis, dark reaction

3 of 4

2.42

2.26

5.55e-05

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016636

Oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor

3 of 3

2.54

1.96

0.00023

GO:0016730

Oxidoreductase activity, acting on iron-sulfur proteins as donors

3 of 5

2.32

1.84

0.00033

GO:0051536

Iron-sulfur cluster binding

5 of 96

1.26

1.09

0.0010

GO:0051539

4 iron, 4 sulfur cluster binding

3 of 43

1.39

0.79

0.0179

GO:0016491

Oxidoreductase activity

6 of 367

0.76

0.49

0.0179

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:29515543

(2018) Evolution of Phototrophy in the Chloroflexi Phylum Driven by Horizontal Gene Transfer.

6 of 12

2.24

4.25

1.32e-09

PMID:31396180

(2019) Evolutionary Implications of Anoxygenic Phototrophy in the Bacterial Phylum Candidatus Eremiobacterota (WPS-2).

4 of 7

2.3

2.76

4.18e-06

PMID:22628531

(2012) Origin and spread of photosynthesis based upon conserved sequence features in key bacteriochlorophyll biosynthesis proteins.

3 of 3

2.54

2.2

8.20e-05

PMID:33801086

(2021) In-Situ Metatranscriptomic Analyses Reveal the Metabolic Flexibility of the Thermophilic Anoxygenic Photosynthetic Bacterium Chloroflexus aggregans in a Hot Spring Cyanobacteria-Dominated Microbial Mat.

3 of 4

2.42

2.11

0.00011

PMID:34006650

(2021) Genomic Analysis of the Yet-Uncultured Binatota Reveals Broad Methylotrophic, Alkane-Degradation, and Pigment Production Capacities.

3 of 9

2.07

1.67

0.00054

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:3881

Photosynthesis, and PucC-related

11 of 25

2.19

7.87

7.21e-21

CL:3883

Mixed, incl. Bacteriochlorophyll metabolic process, and BT1 family

10 of 19

2.27

7.77

3.05e-19

CL:3885

Bacteriochlorophyll metabolic process, and Bacteriochlorophyll/chlorophyll synthetase

6 of 12

2.24

4.62

1.56e-10

CL:3909

Mixed, incl. BT1 family, and Methyltransferase, class B

4 of 6

2.37

3.2

5.72e-07

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

cau00860

Porphyrin and chlorophyll metabolism

10 of 56

1.8

4.67

1.25e-15

cau01110

Biosynthesis of secondary metabolites

9 of 337

0.97

1.08

8.64e-07

cau01100

Metabolic pathways

10 of 670

0.72

0.68

9.16e-06

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0602

Photosynthesis

6 of 11

2.28

4.6

2.58e-10

KW-0077

Bacteriochlorophyll biosynthesis

5 of 7

2.4

4.17

5.32e-09

KW-0408

Iron

5 of 61

1.46

1.67

2.80e-05

KW-0004

4Fe-4S

3 of 28

1.57

1.15

0.0031

KW-0479

Metal-binding

5 of 240

0.86

0.59

0.0099

(more ...)

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