A0A1Y2FZU5 protein (Leucosporidium creatinivorum)

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second shell of interactors

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Known Interactions

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Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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Score

A0A1Y2FZU5

Tryptophan synthase beta subunit-like PLP-dependent enzyme. (496 aa)

Predicted Functional Partners:

A0A1Y2FYH4

0.953

A0A1Y2G444

0.953

A0A1Y2EUU8

0.928

A0A1Y2ECY1

0.919

A0A1Y2CD89

0.915

A0A1Y2FRP3

0.912

A0A1Y2FWZ4

0.912

A0A1Y2F5U3

0.907

A0A1Y2D902

0.902

A0A1Y2E074

0.893

Your Current Organism:

Leucosporidium creatinivorum

NCBI taxonomy Id: 106004
Other names: CBS 8620, L. creatinivorum, Leucosporidiella creatinivora, Leucosporidiella creatinivora (Golubev) J.P. Samp., 2003, Leucosporidium creatinivorum (Golubev) V. de Garcia, M. A. Coelho, T. Maia, L. H. Rosa, A. M. Vaz, C. A. Rosa, J. P. Sampaio, P. Goncalves, M. R. van Broock andD. Libkind, 2015, Rhodotorula creatinivora, Rhodotorula creatinovora, VKM Y-2838

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A1Y2CD89	A0A1Y2D902	Pyridoxal phosphate-dependent transferase.	Tryptophan synthase beta subunit-like PLP-dependent enzyme.	0.915
A0A1Y2CD89	A0A1Y2ECY1	Pyridoxal phosphate-dependent transferase.	Tryptophan synthase.	0.773
A0A1Y2CD89	A0A1Y2EUU8	Pyridoxal phosphate-dependent transferase.	Multifunctional tryptophan biosynthesis protein; Trifunctional enzyme bearing the Gln amidotransferase (GATase) domain of anthranilate synthase, indole-glycerolphosphate synthase, and phosphoribosylanthranilate isomerase activities.	0.535
A0A1Y2CD89	A0A1Y2F5U3	Pyridoxal phosphate-dependent transferase.	Aspartate aminotransferase.	0.524
A0A1Y2CD89	A0A1Y2FZU5	Pyridoxal phosphate-dependent transferase.	Tryptophan synthase beta subunit-like PLP-dependent enzyme.	0.915
A0A1Y2D902	A0A1Y2CD89	Tryptophan synthase beta subunit-like PLP-dependent enzyme.	Pyridoxal phosphate-dependent transferase.	0.915
A0A1Y2D902	A0A1Y2E074	Tryptophan synthase beta subunit-like PLP-dependent enzyme.	Flavodoxin-like domain-containing protein.	0.893
A0A1Y2D902	A0A1Y2ECY1	Tryptophan synthase beta subunit-like PLP-dependent enzyme.	Tryptophan synthase.	0.919
A0A1Y2D902	A0A1Y2EUU8	Tryptophan synthase beta subunit-like PLP-dependent enzyme.	Multifunctional tryptophan biosynthesis protein; Trifunctional enzyme bearing the Gln amidotransferase (GATase) domain of anthranilate synthase, indole-glycerolphosphate synthase, and phosphoribosylanthranilate isomerase activities.	0.928
A0A1Y2D902	A0A1Y2F5U3	Tryptophan synthase beta subunit-like PLP-dependent enzyme.	Aspartate aminotransferase.	0.907
A0A1Y2D902	A0A1Y2FRP3	Tryptophan synthase beta subunit-like PLP-dependent enzyme.	Cys/Met metabolism PLP-dependent enzyme-domain-containing protein.	0.912
A0A1Y2D902	A0A1Y2FWZ4	Tryptophan synthase beta subunit-like PLP-dependent enzyme.	Cys/Met metabolism PLP-dependent enzyme-domain-containing protein.	0.912
A0A1Y2D902	A0A1Y2FYH4	Tryptophan synthase beta subunit-like PLP-dependent enzyme.	Pyridoxal phosphate-dependent transferase.	0.963
A0A1Y2D902	A0A1Y2FZU5	Tryptophan synthase beta subunit-like PLP-dependent enzyme.	Tryptophan synthase beta subunit-like PLP-dependent enzyme.	0.902
A0A1Y2D902	A0A1Y2G444	Tryptophan synthase beta subunit-like PLP-dependent enzyme.	Putative cystathionine gamma-synthase.	0.965
A0A1Y2E074	A0A1Y2D902	Flavodoxin-like domain-containing protein.	Tryptophan synthase beta subunit-like PLP-dependent enzyme.	0.893
A0A1Y2E074	A0A1Y2ECY1	Flavodoxin-like domain-containing protein.	Tryptophan synthase.	0.546
A0A1Y2E074	A0A1Y2EUU8	Flavodoxin-like domain-containing protein.	Multifunctional tryptophan biosynthesis protein; Trifunctional enzyme bearing the Gln amidotransferase (GATase) domain of anthranilate synthase, indole-glycerolphosphate synthase, and phosphoribosylanthranilate isomerase activities.	0.623
A0A1Y2E074	A0A1Y2FRP3	Flavodoxin-like domain-containing protein.	Cys/Met metabolism PLP-dependent enzyme-domain-containing protein.	0.734
A0A1Y2E074	A0A1Y2FWZ4	Flavodoxin-like domain-containing protein.	Cys/Met metabolism PLP-dependent enzyme-domain-containing protein.	0.734

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

46

average node degree:

8.36

avg. local clustering coefficient:

0.948

expected number of edges:

47

PPI enrichment p-value:

0.53

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000398

mRNA splicing, via spliceosome

7 of 229

1.81

3.04

2.77e-08

GO:0010467

Gene expression

9 of 1738

1.04

1.14

4.44e-06

GO:0022618

Ribonucleoprotein complex assembly

3 of 155

1.61

0.8

0.0239

GO:0000387

Spliceosomal snRNP assembly

2 of 30

2.15

0.75

0.0415

GO:0034641

Cellular nitrogen compound metabolic process

9 of 3050

0.79

0.67

0.00044

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:1990935

Splicing factor binding

2 of 4

3.02

1.34

0.0038

GO:0003723

RNA binding

8 of 1208

1.14

1.24

2.24e-05

GO:0003676

Nucleic acid binding

9 of 3699

0.71

0.53

0.0038

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005686

U2 snRNP

5 of 20

2.72

5.12

1.89e-10

GO:0071011

Precatalytic spliceosome

6 of 53

2.38

4.86

1.24e-10

GO:0005684

U2-type spliceosomal complex

6 of 92

2.14

4.22

5.76e-10

GO:0071005

U2-type precatalytic spliceosome

5 of 48

2.34

4.12

5.07e-09

GO:0005681

Spliceosomal complex

7 of 176

1.92

3.93

1.89e-10

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:18986

U2 snRNP, and Nuclear cap binding complex

6 of 23

2.74

5.91

5.02e-12

CL:18988

U2 snRNP

4 of 12

2.84

4.05

3.05e-08

CL:19002

Splicing factor binding, and PSP, proline-rich

3 of 5

3.1

3.14

1.97e-06

CL:19016

U4 snRNP

2 of 5

2.92

1.53

0.0017

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03040

Spliceosome

7 of 266

1.74

3.21

1.84e-09

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-72165

mRNA Splicing - Minor Pathway

6 of 59

2.33

4.64

2.98e-10

MAP-72172

mRNA Splicing

7 of 296

1.7

2.88

1.45e-08

MAP-72203

Processing of Capped Intron-Containing Pre-mRNA

7 of 391

1.57

2.48

5.54e-08

MAP-8953854

Metabolism of RNA

9 of 946

1.3

1.91

1.45e-08

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:1990904

Ribonucleoprotein complex

9 of 447

1.63

3.22

3.44e-11

GOCC:0097525

Spliceosomal snRNP complex

4 of 40

2.32

2.85

2.87e-06

GOCC:0005681

Spliceosomal complex

4 of 107

1.89

2.04

4.99e-05

GOCC:0005687

U4 snRNP

2 of 6

2.84

1.63

0.0011

GOCC:0005689

U12-type spliceosomal complex

2 of 8

2.72

1.53

0.0016

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0687

Ribonucleoprotein

4 of 93

1.96

2.16

3.14e-05

KW-0694

RNA-binding

4 of 347

1.38

1.06

0.0027

KW-0689

Ribosomal protein

2 of 63

1.82

0.7

0.0469

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