node1 | node2 | node1 annotation | node2 annotation | score |
A0A1Y2DFE9 | A0A1Y2DW44 | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] | Ubiquitin-like domain-containing protein. | 0.808 |
A0A1Y2DFE9 | A0A1Y2FW35 | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] | WLM domain-domain-containing protein. | 0.436 |
A0A1Y2DFE9 | A0A1Y2FX18 | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] | Tyrosyl-DNA phosphodiesterase-domain-containing protein. | 0.790 |
A0A1Y2DFE9 | A0A1Y2FXE8 | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] | Ubiquitin-2 like Rad60 SUMO-like-domain-containing protein. | 0.808 |
A0A1Y2DFE9 | A0A1Y2G145 | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] | Tyrosyl-DNA phosphodiesterase-domain-containing protein. | 0.943 |
A0A1Y2DFE9 | A0A1Y2G3L1 | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] | WLM domain-domain-containing protein. | 0.414 |
A0A1Y2DW44 | A0A1Y2DFE9 | Ubiquitin-like domain-containing protein. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] | 0.808 |
A0A1Y2DW44 | A0A1Y2FW35 | Ubiquitin-like domain-containing protein. | WLM domain-domain-containing protein. | 0.489 |
A0A1Y2DW44 | A0A1Y2FX18 | Ubiquitin-like domain-containing protein. | Tyrosyl-DNA phosphodiesterase-domain-containing protein. | 0.408 |
A0A1Y2DW44 | A0A1Y2G145 | Ubiquitin-like domain-containing protein. | Tyrosyl-DNA phosphodiesterase-domain-containing protein. | 0.443 |
A0A1Y2DW44 | A0A1Y2G3L1 | Ubiquitin-like domain-containing protein. | WLM domain-domain-containing protein. | 0.464 |
A0A1Y2FW35 | A0A1Y2DFE9 | WLM domain-domain-containing protein. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] | 0.436 |
A0A1Y2FW35 | A0A1Y2DW44 | WLM domain-domain-containing protein. | Ubiquitin-like domain-containing protein. | 0.489 |
A0A1Y2FW35 | A0A1Y2FX18 | WLM domain-domain-containing protein. | Tyrosyl-DNA phosphodiesterase-domain-containing protein. | 0.454 |
A0A1Y2FW35 | A0A1Y2FXE8 | WLM domain-domain-containing protein. | Ubiquitin-2 like Rad60 SUMO-like-domain-containing protein. | 0.489 |
A0A1Y2FW35 | A0A1Y2G145 | WLM domain-domain-containing protein. | Tyrosyl-DNA phosphodiesterase-domain-containing protein. | 0.454 |
A0A1Y2FW35 | A0A1Y2G3L1 | WLM domain-domain-containing protein. | WLM domain-domain-containing protein. | 0.567 |
A0A1Y2FX18 | A0A1Y2DFE9 | Tyrosyl-DNA phosphodiesterase-domain-containing protein. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] | 0.790 |
A0A1Y2FX18 | A0A1Y2DW44 | Tyrosyl-DNA phosphodiesterase-domain-containing protein. | Ubiquitin-like domain-containing protein. | 0.408 |
A0A1Y2FX18 | A0A1Y2FW35 | Tyrosyl-DNA phosphodiesterase-domain-containing protein. | WLM domain-domain-containing protein. | 0.454 |