A0A1Y2G460 protein (Leucosporidium creatinivorum)

Nodes:

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

A0A1Y2G460

Uncharacterized protein. (1123 aa)

Predicted Functional Partners:

A0A1Y2F032

0.841

A0A1Y2EPI0

0.587

A0A1Y2FKQ6

0.542

A0A1Y2FD50

0.523

A0A1Y2D901

0.505

A0A1Y2EXE8

0.505

A0A1Y2F784

0.505

A0A1Y2F3D6

0.493

A0A1Y2FIP6

0.476

A0A1Y2DZC5

0.473

Your Current Organism:

Leucosporidium creatinivorum

NCBI taxonomy Id: 106004
Other names: CBS 8620, L. creatinivorum, Leucosporidiella creatinivora, Leucosporidiella creatinivora (Golubev) J.P. Samp., 2003, Leucosporidium creatinivorum (Golubev) V. de Garcia, M. A. Coelho, T. Maia, L. H. Rosa, A. M. Vaz, C. A. Rosa, J. P. Sampaio, P. Goncalves, M. R. van Broock andD. Libkind, 2015, Rhodotorula creatinivora, Rhodotorula creatinovora, VKM Y-2838

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A1Y2D901	A0A1Y2G460	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family.	Uncharacterized protein.	0.505
A0A1Y2DZC5	A0A1Y2F3D6	Uncharacterized protein.	Uncharacterized protein.	0.584
A0A1Y2DZC5	A0A1Y2FD50	Uncharacterized protein.	TPR_REGION domain-containing protein.	0.520
A0A1Y2DZC5	A0A1Y2G460	Uncharacterized protein.	Uncharacterized protein.	0.473
A0A1Y2EPI0	A0A1Y2G460	Uncharacterized protein.	Uncharacterized protein.	0.587
A0A1Y2EXE8	A0A1Y2G460	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family.	Uncharacterized protein.	0.505
A0A1Y2F032	A0A1Y2FD50	Uncharacterized protein.	TPR_REGION domain-containing protein.	0.463
A0A1Y2F032	A0A1Y2G460	Uncharacterized protein.	Uncharacterized protein.	0.841
A0A1Y2F3D6	A0A1Y2DZC5	Uncharacterized protein.	Uncharacterized protein.	0.584
A0A1Y2F3D6	A0A1Y2G460	Uncharacterized protein.	Uncharacterized protein.	0.493
A0A1Y2F784	A0A1Y2G460	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family.	Uncharacterized protein.	0.505
A0A1Y2FD50	A0A1Y2DZC5	TPR_REGION domain-containing protein.	Uncharacterized protein.	0.520
A0A1Y2FD50	A0A1Y2F032	TPR_REGION domain-containing protein.	Uncharacterized protein.	0.463
A0A1Y2FD50	A0A1Y2G460	TPR_REGION domain-containing protein.	Uncharacterized protein.	0.523
A0A1Y2FIP6	A0A1Y2FKQ6	SKIP/SNW domain-domain-containing protein.	Uncharacterized protein.	0.963
A0A1Y2FIP6	A0A1Y2G460	SKIP/SNW domain-domain-containing protein.	Uncharacterized protein.	0.476
A0A1Y2FKQ6	A0A1Y2FIP6	Uncharacterized protein.	SKIP/SNW domain-domain-containing protein.	0.963
A0A1Y2FKQ6	A0A1Y2G460	Uncharacterized protein.	Uncharacterized protein.	0.542
A0A1Y2G460	A0A1Y2D901	Uncharacterized protein.	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family.	0.505
A0A1Y2G460	A0A1Y2DZC5	Uncharacterized protein.	Uncharacterized protein.	0.473

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

35

average node degree:

6.36

avg. local clustering coefficient:

0.794

expected number of edges:

11

PPI enrichment p-value:

9.54e-09

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006730

One-carbon metabolic process

4 of 9

2.06

2.24

2.92e-05

GO:0000096

Sulfur amino acid metabolic process

4 of 15

1.84

1.92

7.83e-05

GO:0009066

Aspartate family amino acid metabolic process

5 of 31

1.62

1.86

2.92e-05

GO:0009067

Aspartate family amino acid biosynthetic process

4 of 20

1.71

1.69

0.00018

GO:0006555

Methionine metabolic process

3 of 7

2.04

1.65

0.00058

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004013

Adenosylhomocysteinase activity

3 of 3

2.41

1.79

0.00046

GO:0008172

S-methyltransferase activity

2 of 3

2.23

0.94

0.0180

GO:0019842

Vitamin binding

3 of 36

1.33

0.65

0.0389

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1144

Cysteine and methionine metabolism, and Homoserine kinase activity

10 of 21

2.09

6.38

3.43e-17

CL:1146

Cysteine and methionine metabolism, and Homoserine kinase activity

8 of 15

2.14

5.46

1.68e-13

CL:1147

Adenosylhomocysteinase-like, and Threonine biosynthetic process

7 of 10

2.26

5.36

2.37e-12

CL:1150

Homocysteine-binding domain, and Adenosylhomocysteinase-like

5 of 5

2.41

4.12

7.08e-09

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

ttr00270

Cysteine and methionine metabolism

9 of 32

1.86

4.62

5.66e-14

ttr00450

Selenocompound metabolism

3 of 10

1.89

1.76

0.00023

ttr00260

Glycine, serine and threonine metabolism

4 of 26

1.6

1.71

7.83e-05

ttr01230

Biosynthesis of amino acids

6 of 104

1.17

1.25

3.82e-05

ttr01110

Biosynthesis of secondary metabolites

7 of 253

0.85

0.76

0.00023

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0554

One-carbon metabolism

3 of 7

2.04

1.55

0.00092

KW-0486

Methionine biosynthesis

2 of 4

2.11

0.93

0.0183

KW-0520

NAD

3 of 38

1.31

0.71

0.0256

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02574

Homocysteine S-methyltransferase

2 of 2

2.41

0.79

0.0365

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR042172

Adenosylhomocysteinase-like superfamily

3 of 3

2.41

1.61

0.0010

IPR020082

S-adenosyl-L-homocysteine hydrolase, conserved site

3 of 3

2.41

1.61

0.0010

IPR015878

S-adenosyl-L-homocysteine hydrolase, NAD binding domain

3 of 3

2.41

1.61

0.0010

IPR000043

Adenosylhomocysteinase-like

3 of 3

2.41

1.61

0.0010

IPR036589

Homocysteine-binding domain superfamily

2 of 2

2.41

0.93

0.0196

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00997

S-adenosyl-L-homocysteine hydrolase, NAD binding domain

3 of 3

2.41

2.14

9.34e-05

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