node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABD10586.1 | ABD10587.1 | Francci3_1208 | Francci3_1209 | FolC bifunctional protein; Belongs to the folylpolyglutamate synthase family. | Folylpolyglutamate synthase-like. | 0.963 |
ABD10586.1 | ABD13189.1 | Francci3_1208 | Francci3_3839 | FolC bifunctional protein; Belongs to the folylpolyglutamate synthase family. | Dihydropteroate synthase. | 0.975 |
ABD10586.1 | ABD13751.1 | Francci3_1208 | Francci3_4405 | FolC bifunctional protein; Belongs to the folylpolyglutamate synthase family. | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase. | 0.598 |
ABD10586.1 | ABD13752.1 | Francci3_1208 | Francci3_4406 | FolC bifunctional protein; Belongs to the folylpolyglutamate synthase family. | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 0.668 |
ABD10586.1 | ABD13753.1 | Francci3_1208 | Francci3_4407 | FolC bifunctional protein; Belongs to the folylpolyglutamate synthase family. | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.996 |
ABD10586.1 | folD1 | Francci3_1208 | Francci3_1492 | FolC bifunctional protein; Belongs to the folylpolyglutamate synthase family. | Methenyltetrahydrofolate cyclohydrolase / 5,10-methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.697 |
ABD10586.1 | glyA | Francci3_1208 | Francci3_0624 | FolC bifunctional protein; Belongs to the folylpolyglutamate synthase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.599 |
ABD10586.1 | glyA-2 | Francci3_1208 | Francci3_3717 | FolC bifunctional protein; Belongs to the folylpolyglutamate synthase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.599 |
ABD10586.1 | guaA | Francci3_1208 | Francci3_0645 | FolC bifunctional protein; Belongs to the folylpolyglutamate synthase family. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.632 |
ABD10586.1 | ndk | Francci3_1208 | Francci3_1210 | FolC bifunctional protein; Belongs to the folylpolyglutamate synthase family. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.565 |
ABD10587.1 | ABD10586.1 | Francci3_1209 | Francci3_1208 | Folylpolyglutamate synthase-like. | FolC bifunctional protein; Belongs to the folylpolyglutamate synthase family. | 0.963 |
ABD10587.1 | ABD13189.1 | Francci3_1209 | Francci3_3839 | Folylpolyglutamate synthase-like. | Dihydropteroate synthase. | 0.962 |
ABD10587.1 | ABD13751.1 | Francci3_1209 | Francci3_4405 | Folylpolyglutamate synthase-like. | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase. | 0.593 |
ABD10587.1 | ABD13752.1 | Francci3_1209 | Francci3_4406 | Folylpolyglutamate synthase-like. | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 0.722 |
ABD10587.1 | ABD13753.1 | Francci3_1209 | Francci3_4407 | Folylpolyglutamate synthase-like. | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.972 |
ABD10587.1 | guaA | Francci3_1209 | Francci3_0645 | Folylpolyglutamate synthase-like. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.560 |
ABD10587.1 | ndk | Francci3_1209 | Francci3_1210 | Folylpolyglutamate synthase-like. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.572 |
ABD13189.1 | ABD10586.1 | Francci3_3839 | Francci3_1208 | Dihydropteroate synthase. | FolC bifunctional protein; Belongs to the folylpolyglutamate synthase family. | 0.975 |
ABD13189.1 | ABD10587.1 | Francci3_3839 | Francci3_1209 | Dihydropteroate synthase. | Folylpolyglutamate synthase-like. | 0.962 |
ABD13189.1 | ABD13751.1 | Francci3_3839 | Francci3_4405 | Dihydropteroate synthase. | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase. | 0.997 |