STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hemCHydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (309 aa)    
Predicted Functional Partners:
ARG18531.1
uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
  
 0.997
ARG18874.1
Delta-aminolevulinic acid dehydratase; Catalyzes the formation of porphobilinogen from 5-aminolevulinate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ALAD family.
 
 0.994
cysG
uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family.
  
 0.993
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
 
 0.982
hemA
glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
  
 0.968
hemL
Aspartate aminotransferase family protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.903
ARG18530.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.883
ARG18922.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.763
argH
Argininosuccinate lyase; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
 0.690
ARG18921.1
Thioesterase; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.669
Your Current Organism:
Acinetobacter nosocomialis
NCBI taxonomy Id: 106654
Other names: A. nosocomialis, Acinetobacter genomosp. 13TU, Acinetobacter genosp. 13TU, Acinetobacter nosocomialis Nemec et al. 2011, Acinetobacter sp. NF108071, Acinetobacter sp. WC-487, CCM 7791, CCUG 74064, LMG 10619, LMG:10619, NIPH 2119, strain RUH 2376
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