STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ctsRTranscriptional regulator; Belongs to the CtsR family. (155 aa)    
Predicted Functional Partners:
clpB
ATP-binding Clp protease subunit; Belongs to the ClpA/ClpB family.
  
  
 0.938
clpB-2
Chaperone ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family.
  
  
 0.587
LRC_00530
ATP-dependent Clp protease, ATP-binding subunit; Belongs to the ClpA/ClpB family.
  
  
 0.586
LRC_06950
ATP-dependent Clp protease ATP-binding subunit; Belongs to the ClpA/ClpB family.
  
  
 0.586
LRC_12040
Signal recognition particle associated protein; Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY/ffh. May be a regulatory protein.
  
     0.533
hrcA
Heat-inducible transcription repressor; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons.
   
  
 0.504
rpoB
DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
       0.484
LRC_02580
Hypothetical protein.
       0.465
clpP
ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.
   
  
 0.433
groS
Chaperonin GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.
  
  
 0.424
Your Current Organism:
Lactobacillus ruminis
NCBI taxonomy Id: 1069534
Other names: L. ruminis ATCC 27782, Lactobacillus ruminis ATCC 27782, Lactobacillus ruminis str. ATCC 27782, Lactobacillus ruminis strain ATCC 27782
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.