PNEG_00453 protein (Pneumocystis murina) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

PNEG_00453

Uncharacterized protein. (109 aa)

Predicted Functional Partners:

PNEG_03508

0.914

PNEG_02985

0.854

PNEG_00454

0.812

PNEG_00871

0.735

PNEG_02794

0.596

PNEG_02314

0.572

PNEG_03362

0.561

PNEG_02618

0.544

PNEG_02193

0.544

PNEG_02921

0.539

Your Current Organism:

Pneumocystis murina

NCBI taxonomy Id: 1069680
Other names: P. murina B123, Pneumocystis murina B123

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PNEG_00453	PNEG_00454	M7NRQ7	M7PLU4	Uncharacterized protein.	Uncharacterized protein.	0.812
PNEG_00453	PNEG_00871	M7NRQ7	M7NUD9	Uncharacterized protein.	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.735
PNEG_00453	PNEG_02193	M7NRQ7	M7P6U5	Uncharacterized protein.	5'-3' exoribonuclease; Possesses 5'->3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II.	0.544
PNEG_00453	PNEG_02314	M7NRQ7	M7PFY1	Uncharacterized protein.	Transcription elongation factor SPT5; The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene.	0.572
PNEG_00453	PNEG_02618	M7NRQ7	M7NP00	Uncharacterized protein.	Uncharacterized protein.	0.544
PNEG_00453	PNEG_02794	M7NRQ7	M7NPJ4	Uncharacterized protein.	Nuclear cap-binding protein subunit 2.	0.596
PNEG_00453	PNEG_02921	M7NRQ7	M7NJF9	Uncharacterized protein.	Sister chromatid cohesion protein.	0.539
PNEG_00453	PNEG_02985	M7NRQ7	M7NJN7	Uncharacterized protein.	RRM domain-containing protein.	0.854
PNEG_00453	PNEG_03362	M7NRQ7	M7NM23	Uncharacterized protein.	Uncharacterized protein.	0.561
PNEG_00453	PNEG_03508	M7NRQ7	M7NHM3	Uncharacterized protein.	Uncharacterized protein.	0.914
PNEG_00454	PNEG_00453	M7PLU4	M7NRQ7	Uncharacterized protein.	Uncharacterized protein.	0.812
PNEG_00454	PNEG_00871	M7PLU4	M7NUD9	Uncharacterized protein.	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.735
PNEG_00454	PNEG_02193	M7PLU4	M7P6U5	Uncharacterized protein.	5'-3' exoribonuclease; Possesses 5'->3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II.	0.544
PNEG_00454	PNEG_02314	M7PLU4	M7PFY1	Uncharacterized protein.	Transcription elongation factor SPT5; The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene.	0.572
PNEG_00454	PNEG_02618	M7PLU4	M7NP00	Uncharacterized protein.	Uncharacterized protein.	0.544
PNEG_00454	PNEG_02794	M7PLU4	M7NPJ4	Uncharacterized protein.	Nuclear cap-binding protein subunit 2.	0.596
PNEG_00454	PNEG_02921	M7PLU4	M7NJF9	Uncharacterized protein.	Sister chromatid cohesion protein.	0.539
PNEG_00454	PNEG_02985	M7PLU4	M7NJN7	Uncharacterized protein.	RRM domain-containing protein.	0.854
PNEG_00454	PNEG_03362	M7PLU4	M7NM23	Uncharacterized protein.	Uncharacterized protein.	0.561
PNEG_00454	PNEG_03508	M7PLU4	M7NHM3	Uncharacterized protein.	Uncharacterized protein.	0.914

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

19

average node degree:

3.45

avg. local clustering coefficient:

0.842

expected number of edges:

11

PPI enrichment p-value:

0.0142

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0001503

Ossification

7 of 108

2.13

4.4

1.78e-10

GO:0045597

Positive regulation of cell differentiation

7 of 478

1.48

2.07

6.58e-07

GO:2000026

Regulation of multicellular organismal development

9 of 838

1.35

2.0

2.63e-08

GO:0051094

Positive regulation of developmental process

8 of 738

1.35

1.87

3.04e-07

GO:0002062

Chondrocyte differentiation

3 of 45

2.14

1.8

0.00032

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005667

Transcription regulator complex

4 of 371

1.35

0.71

0.0270

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:31879

RUNX1 regulates transcription of genes involved in differentiation of HSCs, and Runt domain

5 of 30

2.54

4.08

1.43e-08

CL:31881

RUNX1 regulates transcription of genes involved in differentiation of HSCs, and FOG family

3 of 21

2.47

2.18

8.33e-05

CL:31886

Mixed, incl. RUNX3 regulates p14-ARF, and LIM interaction domain

2 of 6

2.84

1.42

0.0027

CL:31925

Mixed, incl. Runt domain, and Paired-box protein 2 C-terminal

2 of 7

2.77

1.38

0.0031

CL:41371

Mixed, incl. Ubiquinone and other terpenoid-quinone biosynthesis, and Osteocalcin/matrix Gla protein

2 of 15

2.44

1.09

0.0102

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-8951936

RUNX3 regulates p14-ARF

2 of 6

2.84

1.36

0.0035

MAP-8939246

RUNX1 regulates transcription of genes involved in differentiation of myeloid cells

2 of 4

3.02

1.36

0.0035

MAP-8931987

RUNX1 regulates estrogen receptor mediated transcription

2 of 3

3.14

1.36

0.0035

MAP-8877330

RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)

2 of 4

3.02

1.36

0.0035

MAP-8934593

Regulation of RUNX1 Expression and Activity

2 of 8

2.72

1.35

0.0035

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00853

Runt domain

4 of 4

3.32

4.59

4.60e-09

PF08504

Runx inhibition domain

3 of 3

3.32

3.17

1.88e-06

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR013524

Runt domain

4 of 4

3.32

4.32

1.44e-08

IPR000040

Acute myeloid leukemia 1 protein (AML1)/Runt

4 of 4

3.32

4.32

1.44e-08

IPR012346

p53/RUNT-type transcription factor, DNA-binding domain superfamily

4 of 7

3.07

4.18

2.26e-08

IPR027384

Runx, central domain superfamily

3 of 3

3.32

3.06

2.94e-06

IPR016554

Runt-related transcription factor RUNX

3 of 3

3.32

3.06

2.94e-06

(more ...)

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (28%) [HD]

Permalink

Network

Fusion

Experiments

Cooccurrence

Databases

Coexpression

Textmining

Neighborhood

© STRING Consortium 2025

Credits

Access

Info

About